Diagnostic techniques for inflammatory eye disease: past, present and future: a review
BMC Ophthalmology 2013, 13:41 doi:10.1186/1471-2415-13-41
Published: 8 August 2013August 16, 2013
=
August 15, 2013
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit.
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit
World Allergy Organization Journal 2013, 6:13 doi:10.1186/1939-4551-6-13
Published: 6 August 2013Abstract (provisional)
Background
Methods
Results
Conclusions
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production. |
Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection
dynamics of airway smooth muscle cells (ASMC) mediate ASMC contraction and proliferation, and thus play a key role in airway hyper-responsiveness (AHR) and remodelling in asthma. We evaluate the importance of store-operated 
entry (SOCE) in these 
dynamics by constructing a mathematical model of ASMC 
signaling based on experimental data from lung slices. The model confirms that SOCE is elicited upon sufficient 
depletion of the sarcoplasmic reticulum (SR), while receptor-operated 
entry (ROCE) is inhibited in such conditions. It also shows that SOCE can sustain agonist-induced 
oscillations in the absence of other 
influx. SOCE up-regulation may thus contribute to AHR by increasing the 
oscillation frequency that in turn regulates ASMC contraction. The model also provides an explanation for the failure of the SERCA pump blocker CPA to clamp the cytosolic 
of ASMC in lung slices, by showing that CPA is unable to maintain the SR empty of 
. This prediction is confirmed by experimental data from mouse lung slices, and strongly suggests that CPA only partially inhibits SERCA in ASMC.The Presence of Asthma, the Use of Inhaled Steroids, and Parental Education Level Affect School Performance in Children
BioMed Research International
Volume 2013 (2013), Article ID 762805, 7 pages
http://dx.doi.org/10.1155/2013/762805
Research Article
The Presence of Asthma, the Use of Inhaled Steroids, and Parental Education Level Affect School Performance in Children
1Michalinio Pediatric Development Centre, Ministry of Employment, Athens, Greece
2Respiratory Unit, Department of Pediatrics, Academic General Hospital of Alexandroupolis, Dragana, Alexandroupolis, Thrace, Greece
3Department of Electrical and Computer Engineering, Democritus University of Thrace, Xanthi, Greece
4Department of Statistics and Actuarial-Financial Mathematics, University of the Aegean, Samos, Greece
5Respiratory Department, General Hospital of Athens “ELPIS,” Athens, Greece
2Respiratory Unit, Department of Pediatrics, Academic General Hospital of Alexandroupolis, Dragana, Alexandroupolis, Thrace, Greece
3Department of Electrical and Computer Engineering, Democritus University of Thrace, Xanthi, Greece
4Department of Statistics and Actuarial-Financial Mathematics, University of the Aegean, Samos, Greece
5Respiratory Department, General Hospital of Athens “ELPIS,” Athens, Greece
Received 22 April 2013; Accepted 17 June 2013
Academic Editor: Oscar Palomares
Copyright © 2013 A. Tsakiris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective. Childhood asthma is a frequent cause of absenteeism that affects school performance. We aimed to investigate the impact of asthma on absenteeism and school performance level of elementary and high school students. Methods. Data about sociodemographics, absenteeism, and academic achievement were obtained from 1539 students attending 98 schools in Greece. School performance was assessed for the last two years of school attendance using parents’ and teachers’ reports and grade point average promotion. Results. The mean of the days of absence of students with asthma was higher compared to the healthy students (6.2 ± 11.7 versus 0.3 ± 3.1, resp., ). Students with reduced healthcare use presented less absenteeism than those with increased healthcare use for asthma (4.3 ± 8.6 versus 12.4 ± 17.0 days, resp., ). Asthma and healthcare use for asthma accounted for an overall estimated variability in absence days of 13.8% and 9%, respectively. Absenteeism was associated with poor school performance for the last two years of school () and with lower grade point promotion in elementary school students () but not in high school students (). Higher level of parental education was associated with better school performance (). Asthma was associated with a decreased possibility for excellent performance (OR = 0.64, , 95%CI = 0.41–1.00) in elementary students. Students with asthma using inhalers were four times more likely to perform excellently in elementary school (OR = 4.3, , 95%CI = 1.17–15.95) than their asthmatic peers with alternative asthma treatments. Conclusions. Asthma and increased healthcare use enhance school absenteeism. Inhaled steroid use and the higher parental education level were the most important predicting factors for good school performance in elementary school asthmatic children.
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