Adult Atopic Dermatitis Patients and Physical Exercise: A Swedish Questionnaire Study

INVESTIGATIVE REPORT

doi: 10.2340/00015555-1556

Abstract:

Physical activity promotes health and prevents disease. When patients with atopic dermatitis (AD) undertake exercise, the itch often gets worse due to sweating, and this may reduce their engagement in physical exercise. The aim of this study was to determine the level of physical exercise in patients with AD compared with a control group from a normal population. Our hypothesis was that patients with AD have a lower level of physical exercise due to their skin disease. A total of 110 patients with AD and 196 subjects from a normal population, age range 20–34 years, answered a questionnaire. Eleven patients with AD underwent an in-depth interview. The patients with AD had the same level of physical exercise and attitude to physical exercise as the normal population. Therefore, our hypothesis could not be confirmed. In conclusion, the skin symptoms of AD do not appear to be an obstacle to moderate physical exercise.

Authors:

Sol-Britt Lonne-Rahm, Isabelle Sundström, Klas Nordlind, Lars-Magnus Engström
Unit of Dermatology and Venereology, Department of Medicine Karolinska Institutet, 171 76 Stockholm, Sweden. E-mail: Sol-Britt.Lonne-Rahm@karolinska.se

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Diet and Allergic Diseases among Population Aged 0 to 18 Years: Myth or Reality?

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Open Access

Nutrients 2013, 5(9), 3399-3423; doi:10.3390/nu5093399

Review

Danielle Saadeh ^1,* , Pascale Salameh ¹, Isabelle Baldi ² and Chantal Raherison ^2,3

¹ Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Beirut 6573-14, Lebanon² Laboratory "Santé Travail Environnement", INSERM U897, Institute of Public Health, Epidemiology and Development, University Bordeaux Segalen, Bordeaux 33076, France³ Department of Respiratory Diseases, Bordeaux University Hospital, Magellan Avenue, Pessac 33604, France

* Author to whom correspondence should be addressed.

Received: 28 April 2013; in revised form: 6 August 2013 / Accepted: 7 August 2013 / Published: 29 August 2013

(This article belongs to the Special Issue Nutrition and Respiratory Disease)

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Abstract: Allergic diseases are an important health problem. However, epidemiological studies concerning childhood diet-related allergic diseases are scarce. This review examines published articles dealing with diet, dietary patterns and nutrition in relation with allergic diseases among population aged 0 to 18 years. Studies and trials were identified using MEDLINE/PubMed and Cochrane Database of Systematic Reviews and were limited to those published in English or French from 1992 until 2012. This manuscript also reviews the evidence for maternal diet during pregnancy and diet during early childhood and their association with childhood atopic diseases, taking into account the methodology used to evaluate dietary patterns. The evidence reviewed is derived from large epidemiological studies exploring the effects of different food categories on asthma, atopic dermatitis, and allergic rhinitis in children. Overall, maternal diet during pregnancy and a childhood diet rich in antioxidants and omega-3 fatty acids are considered as healthy diets that could be protective for allergic diseases in childhood.

Keywords: diet; dietary patterns; asthma; allergic rhinitis; atopic dermatitis; atopic diseases; children

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Cite This Article

MDPI and ACS Style

Saadeh, D.; Salameh, P.; Baldi, I.; Raherison, C. Diet and Allergic Diseases among Population Aged 0 to 18 Years: Myth or Reality? Nutrients 2013, 5, 3399-3423.

AMA Style

Saadeh D, Salameh P, Baldi I, Raherison C. Diet and Allergic Diseases among Population Aged 0 to 18 Years: Myth or Reality? Nutrients. 2013; 5(9):3399-3423.

Chicago/Turabian Style

Saadeh, Danielle; Salameh, Pascale; Baldi, Isabelle; Raherison, Chantal. 2013. "Diet and Allergic Diseases among Population Aged 0 to 18 Years: Myth or Reality?" Nutrients 5, no. 9: 3399-3423.

Drug-induced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFα agents

• Wiley-Blackwell Online Open
• PMC3561694

Journal Der Deutschen Dermatologischen Gesellschaft

Wiley-Blackwell, John Wiley & Sons

J Dtsch Dermatol Ges. 2012 December; 10(12): 889–897.

doi:  10.1111/j.1610-0387.2012.08000.x

PMCID: PMC3561694

Camilla Dalle Vedove,1 Jan C Simon,2 and Giampiero Girolomoni1

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Abstract

Drug-induced lupus erythematosus (DILE) is a lupus-like syndrome temporally related to continuous drug exposure which resolves upon drug discontinuation. There are currently no standard diagnostic criteria for DILE. Findings include skin manifestations, arthritis, serositis, anti-nuclear and anti-histone antibodies positivity. Similarly to idiopathic lupus erythematosus, DILE can be divided into systemic (SLE), subacute cutaneous (SCLE) and chronic cutaneous lupus (CCLE). Systemic DILE presents as a milder version of idiopathic SLE, and the drugs most frequently implicated are hydralazine, procainamide and quinidine. Anti-TNFα therapies are the latest class of medications found to be associated, although rarely, with a “lupus-like” syndrome, which is however clinically distinct from classical DILE. Drug-induced SCLE is the most common form of DILE. It is very similar to idiopathic SCLE in terms of clinical and serologic characteristics. The most commonly implicated drugs are antihypertensive drugs and terbinafine, but in recent years also proton pump inhibitors and chemotherapeutic agents have been associated. Drug-induced CCLE is very rare and usually caused by fluorouracil agents and NSAIDS, but some cases have induced by pantoprazole and anti-TNFα agents.

Keywords: drug reactions, lupus erythematosus, drug-induced lupus erythematosus

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Changes in CT Scan-estimated Airway Dimensions during an Acute Exacerbation of Asthma

Internal Medicine
Vol. 52 (2013) No. 6 p. 679-683

Language:      English     Japanese   

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http://dx.doi.org/10.2169/internalmedicine.52.8908

 

DN/JST.JSTAGE/internalmedicine/52.8908

CASE REPORTS

Yee Hyung Kim¹⁾, Young Kyung Lee²⁾, Jee-Hong Yoo¹⁾

1) Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Republic of Korea 2) Department of Radiology, Seoul Medical Center, Republic of Korea

 Released on J-STAGE 20130315  

Keywords: asthma, CT, airway dimensions, exacerbation

Abstract: Asthma is a chronic airway disease characterized by reversible airflow limitation with airway wall thickening. Although some studies have reported changes in airway dimensions estimated on chest CT in patients with chronic asthma, little is known about dynamic changes in airway dimensions between acute exacerbations of asthma and recovery. Our case documents significant changes in the bronchial wall, as estimated on serial chest CT scans, over a short-term interval during an exacerbation of asthma.

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Comparison of conjunctival and nasal provocation tests in allergic rhinitis children with Dermatophagoides pteronyssinus sensitization

 

Vol. 31, No. 3, September 2013 Special issue in Pediatric Allergy > Anantasit

Nualnapa Anantasit, Soamarat Vilaiyuk, Wasu Kamchaisatian, Wasu Supakornthanasarn, Cherapat Sasisakulporn, Wanlapa Teawsomboonkit, Suwat Benjaponpitak

Abstract

Background: Nasal provocation tests (NPTs) are indicated in confirming the diagnosis of allergic rhinitis if the clinical history, skin tests or sIgE are inconclusive. NPTs are time- consuming, technically difficult and expensive to perform. Consequently, conjunctival provocation tests (CPTs), which are easier, cheaper and safer should be considered as an alternative method. No recent study has compared CPTs with NPTs in allergic rhinitis children.

Objective: To compare CPTs with NPTs in allergic rhinitis children with house dust mite sensitization

Methods: Fifty-five children with allergic rhinitis were included.  Thirty-six children had positive skin prick tests (SPTs) to Dermatophagoides pteronyssinus (Dp). NPTs were performed by spraying 0.1 ml of Dp extract with concentrations of 50, 200 and 500 AU/ml to each nostril at 15 minute interval. The clinical symptom scores, anterior rhinomanometry results and nasal peak flow testing were performed to assess the responses. For CPTs, 0.1 ml of the same concentration of allergen extract was dropped
into one eye and the control solution was dropped into the other. The responses were assessed by clinical symptom scores. The tests were stopped when the subject reported a positive response, or continued to the maximum concentration.

Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CPT compared with NPT are 97.1% (84.7-99.9), 90.5% (69.6-98.8), 94.3% (80.8-99.3), 95% (75.1-99.9) and 94.5 (84.9-98.9), respectively in all patients. Among individual allergic rhinitis subjects the sensitivity, specificity, PPV and NPV are 100%.

Conclusions: CPT can be an alternative test for NPT in allergic rhinitis children with house dust mite sensitization, even if they do not have conjunctival symptoms. te sensitization

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Hypersensitivity Reaction and Tolerance Induction to Ethambutol

• Case Rep Med
• v.2013; 2013
• PMC3745882

Case Rep Med. 2013; 2013: 208797.

Published online 2013 July 28. doi:  10.1155/2013/208797

PMCID: PMC3745882

Josefina Rodrigues Cernadas, 1 ,* Natacha Santos, 1 Claudia Pinto, 2 Patricia Caetano Mota, 3 and Mariana Castells 4

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Abstract

Tuberculosis remains the leading cause of death worldwide from any infectious agent and the alarming increase in the annual incidence of new cases has been described as a global emergency. Mycobacteriuminfection requires simultaneous administration of multiple drugs. Although the majority of treatment courses progress with minor side effects, adverse reactions to antituberculosis drugs occur in about 5% of treated patients and can be responsible for cessation or switching the therapy. Both nonimmediate (mostly maculopapular rash) and immediate reactions (urticarial reactions) have been described with these drugs. The main problem is the occurrence of reactions while the patient is on treatment with multiple drugs. The diagnosis of the culprit drug is mostly based on stopping all medication, followed by the reintroduction of each drug with a time interval of four to five days. An alternative drug should be the first approach if it is equally effective. Most of the times, none of the alternative drugs are as effective as the culprit. If this is the case, a desensitization procedure should be performed. The authors describe a case of a woman with Mycobacterium avium complex (MAC) infection, to whom treatment with ethambutol was crucial to recovery, and present a modified desensitization protocol to this drug.

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The peculiarities of food allergies in accordance with the level of injury of respiratory tract in children of Eastern Siberia

• Int J Circumpolar Health
• v.72; 2013
• PMC3753160

Int J Circumpolar Health. 2013; 72: 10.3402/ijch.v72i0.21202.

Published online 2013 August 5. doi:  10.3402/ijch.v72i0.21202

PMCID: PMC3753160

Irina V. Borisova* and Svetlana V. Smirnova

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Abstract

Aim

To determine the course of food allergy in accordance with the level of respiratory tract injury in children of Eastern Siberia.

Design of the research

We have examined 70 children aged 2–16 , who have food sensibilization. We divided them into 2 groups: group I (n=32) with diseases of the upper and middle respiratory tract; and group II (n=38) with diseases of the lower respiratory tract.

Methods

Allergological medical history, clinical laboratory examination and immunological examination, including the determination of IgA, IgM, IgG and IgE in blood serum. In cases where causal allergens were found, elimination diets were recommended.

Results

Onset of upper respiratory tract injury in group I was more often registered in children aged 0–1; in group II, it was in the 3–7 age group. Isolated food sensibilization was more often marked in group I as compared to group II. Atopic mechanisms of respiratory tract injuries were more often registered in group II children. In the course of the elimination diet, we marked positive dynamics in 100% of group I and in 75% of group II

Conclusion

The most frequent allergens that cause respiratory forms of food allergy are hen eggs, cow milk, nutritive cereals, vegetables and fruit. Indices of a humoral link of immunity in the examined patients were more often registered as normal or their level is increased. Timely etiotropic therapy in the majority of cases allows for a stabilization of allergic inflammation.

Keywords: food allergy, respiratory tract, elimination diet

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The efficacy of allergen immunotherapy with cat dander in reducing symptoms in clinical practice

• Biomed Res Int
• v.2013; 2013
• PMC3747492

Biomed Res Int. 2013; 2013: 324207.

Published online 2013 July 31. doi:  10.1155/2013/324207

PMCID: PMC3747492

Aerik A. Williams,* John R. Cohn, Shirley M. Fung, and Patricia Padams

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Abstract

Background. Allergy to cat dander is a common form of allergic disease. Allergen immunotherapy has been demonstrated to be effective in decreasing allergic symptoms. Objectives. To examine outcomes in allergic asthmatic patients on cat immunotherapy (CIT) compared to allergic asthmatics on traditional immunotherapy (IT) without cat sensitivity. Methods. A retrospective review identified allergic asthmatics on CIT for at least three years. An equal number of allergic asthmatics on IT were identified for comparison. Outcomes investigated include measurements of risk of asthma exacerbation. Results. Thirty-five patients were identified in each group. There were no differences in the CIT group versus the comparison group regarding total number of prednisone tapers (18 tapers versus 14 tapers, resp.), number of patients requiring prednisone tapers (10 patients versus 10 patients, resp.), total number of acute visits (29 visits versus 38 visits, resp.), and number of patients requiring acute visits (15 patients versus 21 patients, resp.). When stratified by concomitant ICS use, patients on CIT were less likely to require an acute visit (46% versus 78%, resp.). Conclusions. Allergic asthmatics with cat sensitivity on CIT with close dander exposure have similar risk of asthma exacerbation compared to allergic asthmatics without cat sensitivity on immunotherapy.

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