Cross-reactivity of a new food ingredient, dun pea, with legumes, and risk of anaphylaxis in legume allergic children

C. Richard, S. Jacquenet, P. Sergeant, D.A. Moneret-Vautrin

Background. Legume allergy is the fifth food allergy in Europe. The dun pea (Pisum sativum sativum var. arvense), a pea belonging to the same subspecies as green pea, has been recently introduced as an ingredient in the human food industry. The aims of this study were to evaluate the cross-reactivity between dun pea and other legumes and to search for modification of allergenicity induced by food technologies. Methods. A series of 36 patients with legume and/or peanut allergy was studied. They underwent skin tests to peanut and a panel of legumes including dun pea.

Seasonal allergic rhinitis affects sinonasal microbiota.

Am J Rhinol Allergy. 2014 Jul-Aug;28(4):281-6. doi: 10.2500/ajra.2014.28.4050.

Choi CH1, Poroyko V, Watanabe S, Jiang D, Lane J, deTineo M, Baroody FM, Naclerio RM, Pinto JM.

Abstract

BACKGROUND:

Microbes and allergens can stimulate the nasal mucosa, potentially leading to the development of acute bacterial rhinosinusitis (ABRS). This study was designed to determine if allergen exposure alters the sinonasal microbiome.

METHODS:

We performed a parallel observational study of healthy adults with seasonal allergic rhinitis (SAR; grass or tree, n = 20) or nonallergic subjects (n = 19).

The expanding family of regulatory B cells

Claudia Mauri and 

Madhvi Menon

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Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK

1. Correspondence to: C. Mauri; E-mail: c.mauri@ucl.ac.uk

• 
  

Abstract Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (Bregs), contributes to the maintenance of tolerance, primarily via the production of IL-10.

Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study

Brief Communication

Nadine Jaeckels^1*, Iris Bellinghausen², Petra Fronk¹, Bärbel Heydenreich², Joachim Saloga² and Heinz Decker^1*

Clinical and Translational Allergy 2015, 5:21  doi:10.1186/s13601-015-0065-8

Published: 22 June 2015

Abstract

Background

In a recently performed survey with 4000 randomly selected persons, 68 (7.2 %) of 948 respondents reported intolerance and/or allergy-like symptoms to wine. The aim of this study was to analyze whether a real sensitization to wine proteins could be confirmed by diagnostic and/or immunological settings.

Serum reactome induced by Bordetella pertussis infection and Pertussis vaccines: qualitative differences in serum antibody recognition patterns revealed by peptide microarray analysis

Methodology article

Davide Valentini^12†, Giovanni Ferrara^345†, Reza Advani⁶, Hans O Hallander⁶ and Markus J Maeurer^12*

BMC Immunology 2015, 16:40  doi:10.1186/s12865-015-0090-3

Davide Valentini and Giovanni Ferrara contributed equally to this work.

Published: 1 July 2015

Abstract

Background

Pertussis (whooping cough) remains a public health problem despite extensive vaccination strategies. Better understanding of the host-pathogen interaction and the detailed B. pertussis (Bp) target recognition pattern will help in guided vaccine design. We characterized the specific epitope antigen recognition profiles of serum antibodies (‘the reactome’) induced by whooping cough andB. pertussis (Bp) vaccines from a case–control study conducted in 1996 in infants enrolled in a Bp vaccine trial in Sweden (Gustafsson, NEJM, 1996, 334, 349–355).

Prevalence of perennial severe allergic asthma in Italy and effectiveness of omalizumab in its management: PROXIMA – an observational, 2 phase, patient reported outcomes study

Research

Giorgio Walter Canonica¹, Marta Bartezaghi², Raffaele Marino² and Laura Rigoni^2*

Clinical and Molecular Allergy 2015, 13:10  doi:10.1186/s12948-015-0019-7

Published: 7 July 2015

Abstract

Background

We designed the PROXIMA study (Patient-Reported Outcomes and Xolair ^® In the Management of Asthma) to determine the proportion of patients with severe asthma sensitive to perennial allergens, and to evaluate asthma control and treatment adherence up to 12 months in patients treated with omalizumab in Italian population. In addition, an ancillary study was designed to explore protein biomarkers and characterize them in relation to severe allergic asthma and treatment effects by proteomic approach.

Racial differences in eosinophilic gastrointestinal disorders among Caucasian and Asian

Allergology International

Volume 64, Issue 3, July 2015, Pages 253–259

Open Access

Original article

• Jun Ito^a, b, 
• Takeo Fujiwara^a, b, , , 
• Reiji Kojima^c, 
• Ichiro Nomura^c

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Abstract

Background

Although there is an increasing number of eosinophilic gastrointestinal disorders (EGID) cases including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), being reported globally, no systematic reviews have been conducted to elucidate the racial differences in these disorders. We aimed to show the racial differences, especially among Caucasians and Asians, in the risk of EoE and EGE.

• Acta Otorhinolaryngol Ital
• v.34(1); 2014 Feb
• PMC3970223

Acta Otorhinolaryngol Ital. 2014 Feb; 34(1): 36–41.

PMCID: PMC3970223

Language: English | Italian

Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history

M. GELARDI,1 L. IANNUZZI,1 S. TAFURI,2 G. PASSALACQUA,3 and N. QUARANTA1

SUMMARY

Rhinitis and rhinosinusitis (with/without polyposis), either allergic or non-allergic, represent a major medical problem. Their associated comorbidities and relationship with family history have so far been poorly investigated. We assessed these aspects in a large population of patients suffering from rhinosinusal diseases.