Effect of anti-gliadin IgY antibody on epithelial intestinal integrity and inflammatory response induced by gliadin

Research article

Naiyana Gujral¹, Ju Won Suh^2* and Hoon H. Sunwoo^1*

BMC Immunology 2015, 16:41  doi:10.1186/s12865-015-0104-1

The electronic version of this article is the complete one and can be found online at:http://www.biomedcentral.com/1471-2172/16/41

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Abstract

Background

Pepsin-trypsin resistant gliadin (PT-gliadin) promotes intestinal tissue inflammation and increases paracellular permeability of immunogenic gliadin peptides into the lamina propria. This leads to the complications seen in the pathogenesis of celiac disease (CD). In this study, specific anti-gliadin IgY antibody was produced and evaluated for its efficacy on gliadin induced intestinal integrity impairment and proinflammatory effects on intestinal epithelial (Caco-2) cell culture model for CD.

Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity

• World J Gastroenterol
• v.21(23); 2015 Jun 21
• PMC4476871

World J Gastroenterol. 2015 Jun 21; 21(23): 7089–7109.

Published online 2015 Jun 21. doi:  10.3748/wjg.v21.i23.7089

PMCID: PMC4476871

Pasquale Mansueto, Alberto D’Alcamo, Aurelio Seidita, and Antonio Carroccio

Author information ► Article notes ► Copyright and License information ►

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, having a prevalence of 12%-30% in the general population. Most patients with IBS attribute their symptoms to adverse food reactions. We review the role of diet in the pathogenesis of IBS and the importance of dietary factors in the management of these patients.

Bilastine: new insight into antihistamine treatment

Review

Erminia Ridolo^1*, Marcello Montagni¹, Laura Bonzano¹, Cristoforo Incorvaia² and Giorgio Walter Canonica³

Clinical and Molecular Allergy 2015, 13:1  doi:10.1186/s12948-015-0008-x

Published: 15 April 2015

Abstract

Bilastine is a new second generation H1-antihistamine recently approved for the symptomatic treatment of allergic rhinitis (AR) and chronic urticaria (CU). Bilastine epitomizes the evolution of research on antihistamines concerning both efficacy and safety.

Clinical development methodology for infusion-related reactions with monoclonal antibodies

Review
Published online 17 July 2015
OPEN

Citation: Clinical & Translational Immunology (2015) 4, e39; doi:10.1038/cti.2015.14

Lucette Doessegger¹ and Maria Longauer Banholzer¹

¹Safety Risk Management, Licensing and Early Development (LEAD), F. Hoffmann-La Roche AG, Basel, Switzerland

Correspondence: Dr L Doessegger, Safety Risk Management, F. Hoffmann-La Roche, Grenzacherstrasse 124, Basel 4070, Switzerland. E-mail: lucette.doessegger@roche.com

Received 20 March 2015; Revised 2 June 2015; Accepted 2 June 2015

of page

Abstract

Infusion-related reactions (IRRs) are common with monoclonal antibodies (mAbs) and timely related to drug administration and have been reported as anaphylaxis, anaphylactoid reactions and cytokine release syndrome, among other terms used. We address risk management measures for individual patients and for the study and propose a consistent reporting approach in an attempt to allow cross-molecule comparisons. Once the symptoms of IRR have resolved, the mAb may be restarted.

Tree pollen allergens – an update from a molecular perspective

Allergy

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.

1. Claudia Asam, 
2. Heidi Hofer, 
3. Martin Wolf,
4. Lorenz Aglas and
5. Michael Wallner^*

Abstract

It is estimated that pollen allergies affect approximately 40% of allergic individuals. In general, tree pollen allergies are mainly elicited by allergenic trees belonging to the orders Fagales, Lamiales, Proteales and Pinales. Over 25 years ago, the gene encoding the major birch pollen allergen Bet v 1 was the first such gene to be cloned and its product characterized.

Occupational exposure to pesticides and respiratory health

Ali Mamane1,2⇑, 

Isabelle Baldi1,2,3, 

Jean-François Tessier2,

Chantal Raherison1,2,4 and 

Ghislaine Bouvier1,2

Abstract

This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.

Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study

Allergology International
Vol. 64 (2015) No. 3 p. 272-276

http://doi.org/10.1016/j.alit.2015.04.002

ORIGINAL ARTICLE

Yu Okada¹⁾, Noriyuki Yanagida¹⁾, Sakura Sato²⁾, Motohiro Ebisawa²⁾

1) Department of Pediatrics, Sagamihara National Hospital 2) Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital

Released on J-STAGE 20150715  

Keywords: Milk hypersensitivity; Disease management; Food allergy; Food hypersensitivity; Specific IgE

•  Full Text PDF [444K]

• Abstracts
• References(25)

Background: Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy. Methods: We retrospectively reviewed subjects with CM allergy who underwent a VL OFC with 3 mL heated CM and had a previous allergic reaction to < 25 mL heated CM in the 2 years before the OFC.

Anomalous cutaneous absorption of allergens as cause of skin prick testing adverse reactions in adult patients. Clinical and experimental evidence

A. Antico, M. Arisi, G. Lima

Background. Paediatric age, active eczema and high number of allergens tested in poly-sensitized patients have been pinpointed as possible risk factors of systemic reactions by skin prick testing. As far as atopic eczema concerns, the higher penetration of the allergens into the skin because of the scraping or micro-injuries is an intuitive rationalization. Purpose of the present study is to provide documentary evidence that adverse reactions elicited by anomalous absorption of allergens can occur also in adult patients with apparently normal skin.