Activation of the Intrinsic Coagulation Pathway in Patients With Chronic Urticaria

Original Article  Open Access

Allergy Asthma Immunol Res. 2015 Sep;7(5):476-482. English. Published online May 22, 2015.  http://dx.doi.org/10.4168/aair.2015.7.5.476

Jung-Ah Kim,1, Sujeoung Kim,2,3, Ji-Eun Kim,1,4 Ja-Yoon Gu,1,4 Hyun Ju Yoo,1,4 Hye-Ryun Kang,2 and Hyun Kyung Kim1,4

Abstract

Purpose Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors.

Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care

Research

Sinisa Savic¹, Alexander Marsland², David McKay³, Michael R Ardern-Jones⁴, Tabi Leslie⁵⁶, Olivier Somenzi⁷, Laura Baldock⁸ and Clive Grattan^69*

Allergy, Asthma & Clinical Immunology 2015, 11:21  doi:10.1186/s13223-015-0088-7

Abstract

Background

Omalizumab is approved in the UK as add-on treatment for chronic spontaneous urticaria (CSU) in patients with inadequate response to H ₁ -antihistamines. Ciclosporin is an established but unlicensed 3rd line option for CSU. Two parallel retrospective observational studies were conducted to describe outcomes of treatment and adverse events with omalizumab or ciclosporin for CSU treatment.

Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Cross-Intolerance Reactions

Blanca-López N1*, Cornejo-García JA2,3*, Plaza-Serón MC2, Doña I3, Torres-Jaén MJ3, Canto G1, Padilla-España L4, Kidon M5, Perkins JR2, Blanca M3 1Allergy Service, Infanta Leonor Hospital, Madrid, Spain 2Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain 3Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain 4Dermatology Service and Research Unit, Costa del Sol Hospital, Marbella, Spain 5Rheumatology, Immunology and Allergy Service, Department of Paediatric Medicine, Kandang Kerbau Children's Hospital, Singapore *Both authors contributed equally to the manuscript J Investig Allergol Clin Immunol 2015; Vol. 25(4): 259-269    Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide and are responsible for several types of drug hypersensitivity reactions (DHRs) in all age groups. The 2 major groups of DHRs to NSAIDs are those induced by immunological mechanisms (selective reactions) and those where inflammatory mediators are released through activation of the prostaglandin-leukotriene pathway without specific immunological recognition (cross-intolerance). In the present review, we focus on cross-intolerance reactions, which are the most frequent DHRs and are becoming a topic of major interest in children and adolescents.

Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma

Research

G. Rentzos^1*, L. Johanson², S. Sjölander⁴, E. Telemo³ and L. Ekerljung²

Clinical and Translational Allergy 2015, 5:25  doi:10.1186/s13601-015-0067-6

Abstract

Background

There is very few data available on the prevalence of food hypersensitivity among adults with asthma. The aim of this study was to explore the prevalence of self-reported adverse reactions and IgE sensitization to the different foods and to determine the spectrum and the prevalence of food-related gastrointestinal symptoms in adults with and with no asthma.

Epidemiology of Anaphylaxis: Contributions From the Last 10 Years

Tejedor-Alonso MA1,2, Moro-Moro M1, Múgica-García MV3

1Allergy Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain 2Medicine and Surgery Department, Universidad Rey Juan Carlos, Alcorcón, Spain 3Allergy Service, Hospital Universitario de la Princesa, Madrid, Spain

J Investig Allergol Clin Immunol 2015; Vol. 25(3): 163-175

Abstract Knowledge of the epidemiology of anaphylaxis has improved during the last 10 years thanks to the increased number of publications with improved methodological robustness. Consequently, we better understand the distribution and frequency of anaphylaxis and the characteristics of fatal anaphylaxis.

Microbiome and Asthma: What Have Experimental Models Already Taught Us?

Journal of Immunology ResearchVolume 2015 (2015), Article ID 614758, 8 pageshttp://dx.doi.org/10.1155/2015/614758Review Article
R. Bonamichi-Santos, M. V. Aun, R. C. Agondi, J. Kalil, and P. Giavina-Bianchi

Abstract

Asthma is a chronic inflammatory disease that imposes a substantial burden on patients, their families, and the community. Although many aspects of the pathogenesis of classical allergic asthma are well known by the scientific community, other points are not yet understood.

Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis

Case Reports in ImmunologyVolume 2015 (2015), Article ID 780824, 3 pageshttp://dx.doi.org/10.1155/2015/780824Case Report
Amit Frenkel,1 Aviel Roy-Shapira,1 Brotfain Evgeni,1 Koyfman Leonid,1Abraham Borer,2 and Moti Klein1

Abstract

We present a case of a 27-year-old man with recurrent episodes of angioedema since he was 19, who responded well to treatment with medical grade cannabis. Initially, he responded to steroids and antihistamines, but several attempts to withdraw treatment resulted in recurrence.

Probiotics for prevention of atopic diseases in infants:systematic review and meta-analysis

1. 1. 
      
2. Gianvincenzo Zuccotti^1,8, 
3. Fabio Meneghin^2,8, 
4. Arianna Aceti^3,8,*, 
5. Giovanni Barone^4,8,
6. Maria Luisa Callegari^5,8, 
7. Antonio Di Mauro^6,8, 
8. Maria Pia Fantini^7,8, 
9. Davide Gori^7,8,
10. Flavia Indrio^6,8,9, 
11. Luca Maggio^4,8,9,
12. Lorenzo Morelli^5,8, 
13. Luigi Corvaglia^3,8,9,10and
14. The Italian Society of Neonatology.

15. 1. Allergy

       Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
    2. Abstract

       Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic probiotic supplementation during pregnancy and early infancy in preventing atopic diseases.