Tolerability of the SQ-standardised grass sublingual immunotherapy tablet in patients treated with concomitant allergy immunotherapy: a non-interventional observational study

Rainer Reiber, 

Martina Keller, 

Winfried Keller, 

Hendrik Wolf

, 

Jörg Schnitker and 

Eike Wüstenberg

Clinical and Translational Allergy20166:9

DOI: 10.1186/s13601-016-0097-8

Abstract

Background

The majority of allergic patients are poly-sensitized. For causal treatment by allergy immunotherapy (AIT) a single or few allergen products containing the clinically most relevant allergens are applied, but few data on tolerability of multiple application of AIT is available. The aim of our study was to investigate safety and tolerability in patients who started treatment by sublingual immunotherapy (SLIT) with the standardised SQ® grass SLIT-tablet and were treated with concomitant AIT products.

Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis

BMJ 2016; 352 doi: http://dx.doi.org/10.1136/bmj.i974 (Published 08 March 2016)

Cite this as: BMJ 2016;352:i974

1. Robert J Boyle, senior lecturer in paediatric allergy1, 
2. Despo Ierodiakonou, postdoctoral research fellow1 2, 
3. Tasnia Khan, medical student1, 
4. Jennifer Chivinge, medical student1, 
5. Zoe Robinson, medical student1, 
6. Natalie Geoghegan, medical student1, 
7. Katharine Jarrold, medical student1, 
8. Thalia Afxentiou, postgraduate student1, 
9. Tim Reeves, librarian2, 
10. Sergio Cunha, postdoctoral research associate3, 
11. Marialena Trivella, senior medical statistician4, 
12. Vanessa Garcia-Larsen, postdoctoral research fellow2, 
13. Jo Leonardi-Bee, professor of medical statistics5
14. 
    

Abstract

Objective To determine whether feeding infants with hydrolysed formula reduces their risk of allergic or autoimmune disease.

Design Systematic review and meta-analysis, as part of a series of systematic reviews commissioned by the UK Food Standards Agency to inform guidelines on infant feeding. Two authors selected studies by consensus, independently extracted data, and assessed the quality of included studies using the Cochrane risk of bias tool.

Recurrent wheezing in children

 
• Vol 5, No 1 (January 2016) 

Authors: Laura Tenero, Michele Piazza, Giorgio Piacentini

Abstract: Recurrent wheezing have a significant morbidity and it’s estimated that about one third of schoolage children manifest the symptom during the first 5 years of life. Proper identification of children at risk of developing asthma at school age may predict long-term outcomes and improve treatment and preventive approach, but the possibility to identify these children at preschool age remains limited.

Helicobacter pylori in children with asthmatic conditions at school age, and their mothers

Early View (Online Version of Record published before inclusion in an issue)

1. W. J. den Hollander^1,2,*, 
2. A. M. M. Sonnenschein-van der Voort^2,3,4, 
3. I. L. Holster¹, 
4. J. C. de Jongste³, 
5. V. W. Jaddoe^2,5, 
6. A. Hofman⁴, 
7. G. I. Perez-Perez⁶, 
8. H. A. Moll⁵, 
9. M. J. Blaser⁶, 
10. L. Duijts^3,4,7 and
11. E. J. Kuipers^1,8
12. 1. 1. Abstract

       Background

       Helicobacter pylori prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena.

       
       

       Aims

       To examine the association between H. pylori colonisation in children and risk of asthma and related conditions at school age. We secondly examined additional effects of maternal H. pylori status by pairing with children's status.

Prevalence of Peanut, Tree Nut, Sesame, and Seafood Allergy in Mexican Adults

VOLUME 67 - NUMBER 6 / November - December (Original Article)

Martín Bedolla-Barajas, Allergy and Clinical Immunology Service, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jal., Mexico

Tonatiuh Ramses Bedolla-Pulido, Allergy and Clinical Immunology Service, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jal., Mexico

Nicole Macriz-Romero, Universidad Autónoma de Guadalajara, Zapopan, Jal., Mexico

Jaime Morales-Romero, Instituto de Salud Pública, Universidad Veracruzana, Xalapa, Ver., Mexico

Martín Robles-Figueroa, Internal Medicine Service, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jal., Mexico

Abstract:

Objective: To identify the prevalence of perceived and probable allergic reactions to peanuts, tree nuts, sesame seed, or seafood and its association with the personal history of allergic disease. Methods: A cross-sectional study was performed in four cities of the metropolitan area of Guadalajara, located in western Mexico. Through sampling by gender and age, 1,126 subjects were included. Using a structured questionnaire, we investigated: (i) history of atopic disease, (ii) perception of allergic reaction after food intake, and (iii) probable allergic reaction to peanuts, tree nuts, sesame, or seafood. Prevalence and 95% confidence intervals were calculated. A multivariate analysis of factors associated to perceived and probable allergic reactions to food was performed by logistic regression.

Efficacy of MP-AzeFlu in children with seasonal allergic rhinitis: Importance of paediatric symptom assessment

Pediatric Allergy and Immunology

Volume 27, Issue 2, pages 126–133, March 2016

William Berger, 

Eli O. Meltzer, 

Niran Amar, 

Adam T. Fox, 

Jocelyne Just,

Antonella Muraro, 

Antonio Nieto, 

Erkka Valovirta, 

Magnus Wickman

 and

Jean Bousquet

Abstract

Background

This study aimed to assess the efficacy of MP-AzeFlu (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in a single spray) in children with seasonal allergic rhinitis (SAR) and explore the importance of child symptom severity assessment in paediatric allergic rhinitis (AR) trials.

Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis

Early View (Online Version of Record published before inclusion in an issue

1. U. von Arnim^1,*, 
2. T. Wex¹, 
3. A. Link¹, 
4. M. Messerschmidt¹, 
5. M. Venerito¹, 
6. S. Miehlke²and
7. P. Malfertheiner¹

DOI: 10.1111/apt.13560

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Summary

Background

Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. Helicobacter pylori (H. pylori) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and H. pylori may play a protective role in these conditions. Little is known about the relationship between EoE and H. pylori.

Allergic Rhinitis and Chronic Daily Headaches: Is There a Link?

Open Access

Headache (R. B. Halker, Section Editor)

Current Neurology and Neuroscience Reports April 2016, 16:33

• Anna Gryglas 

Abstract

Allergic rhinitis and migraine remain on the list of the most common diseases affecting adults. Migraines and headaches due to allergic rhinitis are easily confused because the symptoms of both conditions often overlap. Both may occur with sinus headache, nasal congestion, and lacrimation and may worsen with weather changes and exposure to allergens. No precise clinical definition exists for what constitutes a sinus headache, which has always been a diagnostic dilemma.