Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations

Allergy Asthma Immunol Res. 2017 Nov;9(6):477-482. https://doi.org/10.4168/aair.2017.9.6.477

Allen P. Kaplan

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA.

Correspondence to: Allen P. Kaplan, MD, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, 171 Ashley Avenue, Charleston, SC 29425, USA. Tel: +1-843-729-0264; Fax: +1-843-722-1253; Email: kaplana@musc.edu

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The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H1-receptor blockers are typically employed up to 4 times a day.

Sublingual immunotherapy provides long-term relief in allergic rhinitis and reduces the risk of asthma: A retrospective, real-world database analysis

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  Open Access
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ORIGINAL ARTICLE

Authors

• DOI: 10.1111/all.13213  View/save citation
• Abstract
  Background

  Allergy immunotherapy (AIT) is the only treatment for allergic rhinitis (AR) and/or allergic asthma (AA) with long-term efficacy. However, there are few real-life data on the progression of AR and/or AA in patients receiving AIT.

Oral Allergy Syndrome (Pollen-Food Allergy Syndrome)

Price, Alexandra MS*; Ramachandran, Sarika MD†; Smith, Gideon P. MD, PhD‡; Stevenson, Mary L. MD†; Pomeranz, Miriam K. MD†; Cohen, David E. MD, MPH†

Dermatitis: March/April 2015 - Volume 26 - Issue 2 - p 78–88

doi: 10.1097/DER.0000000000000087

Reviews

• Abstract
• Author Information
• Article Outline

Oral allergy syndrome (OAS) or pollen-food allergy syndrome (PFS) is a hypersensitivity reaction to plant-based foods, manifesting most commonly with pruritus of the lips, tongue, and mouth. Unlike simple food allergy, OAS requires prior sensitization to a cross-reacting inhalant allergen rather than direct sensitization to a specific food protein. In this review, we summarize the clinical features and pathophysiology of OAS and provide an overview of known pollen-food associations.

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Molecular aspects of allergens in atopic dermatitis

Curr Opin Allergy Clin Immunol. 2017 August; 17(4): 269–277.

Published online 2017 July 28. doi:  10.1097/ACI.0000000000000378

PMCID: PMC5540349

Raffaela Campana,^a Sheron Dzoro,^a Irene Mittermann,^a Elena Fedenko,^b Olga Elisyutina,^b Musa Khaitov,^b Alexander Karaulov,^c and Rudolf Valenta^a

Author information ► Copyright and License information ►

Abstract

Purpose of review

Molecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies.

Fatal Anaphylaxis: Mortality Rate and Risk Factors

September–October, 2017 Volume 5, Issue 5, Pages 1169–1178

Paul J. Turner, MD, PhD

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Elina Jerschow, MD

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Thisanayagam Umasunthar, MD

, 

Robert Lin, MD

, 

Dianne E. Campbell, MD, PhD

, 

Robert J. Boyle, MB, ChB, PhDCorrespondence information about the author MB, ChB, PhD Robert J. BoyleEmail the author MB, ChB, PhD Robert J. Boyle

Open Access

PlumX Metrics

DOI: http://dx.doi.org/10.1016/j.jaip.2017.06.031

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Up to 5% of the US population has suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. Fatal drug anaphylaxis may be increasing, but rates of fatal anaphylaxis to venom and food are stable.

Multicenter prevalence of anaphylaxis in clinic-based oral food challenges

Kwei Akuete, MD, MPH

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Danielle Guffey, MS

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Ryan B. Israelsen, MD

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John M. Broyles, MS, CRNP

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Lori Jo Higgins, LPN

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Todd D. Green, MD

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David R. Naimi, DO

, 

Andrew J. MacGinnitie, MD, PhD

, 

Girish Vitalpur, MD

, 

Charles G. Minard, PhD

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Carla M. Davis, MDCorrespondence information about the author MD Carla M. DavisEmail the author MD Carla M. Davis

Open Access

PlumX Metrics

DOI: http://dx.doi.org/10.1016/j.anai.2017.07.028

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Article Outline

1. Introduction
2. Methods
3. Results
4. Discussion
5. Supplementary Data
6. References

Abstract

Jump to SectionIntroductionMethodsResultsDiscussionSupplementary DataReferences

Background

Although previous single-center studies report the rate of anaphylaxis for oral food challenges (OFCs) as 9% to 11%, little is known regarding the epidemiology of clinical OFCs across multiple centers in the United States.

Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction

Allergy, Asthma & Clinical Immunology

Allergy, Asthma & Clinical Immunology 2017 13:41

https://doi.org/10.1186/s13223-017-0213-x

Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda and Agnieszka Korzeniowska-Kowal

Abstract
Background
Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compounds of the tested immunoglobulins have not been strictly identified.

Sublingual immunotherapy (SLIT) for house dust mites does not prevent new allergen sensitization and bronchial hyper-responsiveness in allergic rhinitis children

PloS One 2017, 12 (8): e0182295

Jae Hyun Lim, Jin Youp Kim, Doo Hee Han, Chul Hee Lee, Seung-No Hong, Jee Hye Wee, Sue K Park, Chae-Seo Rhe

INTRODUCTION: The aim of this study is to identify the effects of sublingual immunotherapy (SLIT) on immunologic parameters and bronchial-hyper-responsiveness in children with allergic rhinitis to house-dust mite (HDM), through long-term follow-up cohort.