Dupilumab: A New Paradigm for the Treatment of Allergic Diseases

Sastre J1, Dávila I2

1Allergy Service, Fundación Jiménez Díaz, and Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
2Institute for Biomedical Research of Salamanca (IBSAL), Allergy Service, University Hospital of Salamanca, and Department of Biomedical and Diagnostics Sciences, Faculty of Medicine, Salamanca, Spain

J Investig Allergol Clin Immunol 2018; Vol 28(3) : 139-150
doi: 10.18176/jiaci.0254

• Abstract

Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the therapeutic options are often very limited. Treatment with systemic corticosteroids and immunosuppressants has adverse effects in the long term, and a significant proportion of patients remain refractory to therapy. In this context, the emerging biological drugs constitute a truly innovative therapeutic approach.

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Allergy Asthma Immunol Res. 2018 Jul; 10(4):354-362. English. Published online February 26, 2018.

So-Yeon Lee,1 Eun Lee,2 Yoon Mee Park,3 and Soo-Jong Hong1

Abstract

The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD. PDF

Association of Inadequately Controlled Disease and Disease Severity With Patient-Reported Disease Burden in Adults With Atopic Dermatitis

Eric L. Simpson, MD¹; Emma Guttman-Yassky, MD, PhD²; David J. Margolis, MD, PhD³; et alSteven R. Feldman, MD, PhD⁴; Abrar Qureshi, MD⁵; Tissa Hata, MD⁶; Vera Mastey, MSc⁷; Wenhui Wei, PhD⁸; Laurent Eckert, PhD⁹; Jingdong Chao⁷; Renée J. G. Arnold, PharmD^10,11; Tiffany Yu, BS¹⁰; Francis Vekeman, MA¹²; Mayte Suárez-Fariñas, PhD¹³; Abhijit Gadkari, PhD⁷

JAMA Dermatol. Published online July 3, 2018. doi:10.1001/jamadermatol.2018.1572

Key Points

Question  What is the association of atopic dermatitis severity and disease control with the patient-reported disease burden in clinical practice?

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Allergy Asthma Immunol Res. 2018 Jul;10(4):300-353. English. https://doi.org/10.4168/aair.2018.10.4.300

Lei Cheng,1,2,† Jianjun Chen,3,† Qingling Fu,4,† Shaoheng He,5,† Huabin Li,6,† Zheng Liu,7,† Guolin Tan,8,† Zezhang Tao,9,† Dehui Wang,6,† Weiping Wen,4,† Rui Xu,4,† Yu Xu,9,† Qintai Yang,10,† Chonghua Zhang,6,† Gehua Zhang,10,† Ruxin Zhang,11,† Yuan Zhang,12,13,14,† Bing Zhou,14,† Dongdong Zhu,15,†Luquan Chen,16 Xinyan Cui,1 Yuqin Deng,9 Zhiqiang Guo,11 Zhenxiao Huang,14 Zizhen Huang,10Houyong Li,6 Jingyun Li,12 Wenting Li,10 Yanqing Li,6 Lin Xi,12 Hongfei Lou,14 Meiping Lu,1 Yuhui Ouyang,12 Wendan Shi,9 Xiaoyao Tao,4 Huiqin Tian,1 Chengshuo Wang,14 Min Wang,12 Nan Wang,7Xiangdong Wang,12,13,14 Hui Xie,17 Shaoqing Yu,18 Renwu Zhao,11 Ming Zheng,14 Han Zhou,1 Luping Zhu,19 and Luo Zhang12,13,14

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries.

Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study

BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k2400 Cite this as: BMJ 2018;361:k2400

1. Kimberly G Blumenthal, assistant professor of medicine123,
2. Na Lu, biostatistician1,
3. Yuqing Zhang, professor of medicine13,
4. Yu Li, research assistant12,
5. Rochelle P Walensky, professor of medicine234,
6. Hyon K Choi, professor of medicine13

Author affiliations

Abstract

Objective To evaluate the relation between penicillin allergy and development of meticillin resistant Staphylococcus aureus (MRSA) and C difficile.

Heat-induced necrosis after bronchial thermoplasty: a new concern?

Case report

Open Access

Allergy, Asthma & Clinical Immunology

• Francesco MenzellaEmail authorView ORCID ID profile,
• Mirco Lusuardi,
• Carla Galeone,
• Gloria Montanari,
• Alberto Cavazza and
• Nicola Facciolongo

Allergy, Asthma & Clinical Immunology201814:25

https://doi.org/10.1186/s13223-018-0252-y

Abstract

Background

Bronchial thermoplasty (BT) is an endoscopic procedure for the treatment of severe refractory asthma, based on the local airways delivery of radio-frequency at 65 °C. Several controlled clinical studies demonstrated the effectiveness of BT on clinical outcomes, particularly the reduction of asthma exacerbations. During procedure or shortly after, significant but transient respiratory adverse events have been reported.

Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children

Research

Open Access

Allergy, Asthma & Clinical Immunology

• Victoria Alejandra Gonzales-GonzálezEmail author,
• Adolfo Martin Díaz,
• Karla Fernández and
• María Félix Rivera

Allergy, Asthma & Clinical Immunology201814:23

https://doi.org/10.1186/s13223-018-0245-x

Abstract

Background

Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries. Honduras has no studies in pediatric patients.

Earlier smoking after waking and the risk of asthma: a cross-sectional study using NHANES data

Research article

Open Access

Open Peer Review

BMC Pulmonary Medicine

• Arielle S. SelyaEmail authorView ORCID ID profile,
• Sunita Thapa and
• Gaurav Mehta

BMC Pulmonary Medicine201818:102

https://doi.org/10.1186/s12890-018-0672-y

Open Peer Review reports

Abstract

Background

Recent research shows that nicotine dependence conveys additional health risks above and beyond smoking behavior. The current study examines whether smoking within 5 min of waking, an indicator of nicotine dependence, is independently associated with asthma outcomes.