| Allergy Asthma Immunol Res. 2018 Jul; 10(4):354-362. English. Published online February 26, 2018. | |
So-Yeon Lee ,1 Eun Lee,2 Yoon Mee Park,3 and Soo-Jong Hong 1 | |
Abstract
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The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.
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| Allergy Asthma Immunol Res. 2018 Jul;10(4):300-353. English. https://doi.org/10.4168/aair.2018.10.4.300 |
Lei Cheng,1,2,† Jianjun Chen,3,† Qingling Fu,4,† Shaoheng He,5,† Huabin Li,6,† Zheng Liu,7,† Guolin Tan,8,† Zezhang Tao,9,† Dehui Wang,6,† Weiping Wen,4,† Rui Xu,4,† Yu Xu,9,† Qintai Yang,10,† Chonghua Zhang,6,† Gehua Zhang,10,† Ruxin Zhang,11,† Yuan Zhang,12,13,14,† Bing Zhou,14,† Dongdong Zhu,15,†Luquan Chen,16 Xinyan Cui,1 Yuqin Deng,9 Zhiqiang Guo,11 Zhenxiao Huang,14 Zizhen Huang,10Houyong Li,6 Jingyun Li,12 Wenting Li,10 Yanqing Li,6 Lin Xi,12 Hongfei Lou,14 Meiping Lu,1 Yuhui Ouyang,12 Wendan Shi,9 Xiaoyao Tao,4 Huiqin Tian,1 Chengshuo Wang,14 Min Wang,12 Nan Wang,7Xiangdong Wang,12,13,14 Hui Xie,17 Shaoqing Yu,18 Renwu Zhao,11 Ming Zheng,14 Han Zhou,1 Luping Zhu,19 and Luo Zhang 12,13,14 | |
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-
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Abstract
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Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries.
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