Unintentional injection to the bone with a pediatric epinephrine auto-injector

• Allergy, Asthma & Clinical Immunology
• Case report
• Open Access

• Mariam Ibrahim and
• Harold KimEmail author

Allergy, Asthma & Clinical Immunology 2018 14:32

Abstract

Background

Skin-to-bone distance (STBD) in children prescribed a pediatric epinephrine auto-injector (EAI) for anaphylaxis is not commonly measured in practice. Recent evidence suggests that children with STBD less than the exposed needle length of available pediatric EAIs (dose: 0.15 mg, needle length: 12.7 mm) are at risk for unintentional injections to the bone during their use for an allergic emergency.

Risk of childhood cerebral palsy following prenatal exposure to ß2-adrenergic receptor agonist: A nationwide cohort study

PLoS One. 2018 Aug 16;13(8):e0202078.

Lin Li, Ziliang Wang , Hong Liang, Fen Yang, Wei Yuan, Bizu Gelaye, Yongfu Yu, Maohua Miao , Mette Nørgaard, Jiong Li

Abstract

Background

Cerebral palsy (CP) is the most common physical developmental disability in childhood with a prevalence of 2 to 3 per 1000 live births. β2-adrenoreceptor agonist (β2AA) are widely used for the treatment of asthma. Maternal use of β2AAs may increase the risk of adverse neuro-psychiatric health outcomes in the offspring. No study, however, has evaluated the effect of prenatal exposure to β2AAs on the risk of CP.

Effectiveness of clarithromycin in patients with yellow nail syndrome

• Research article
• Open Access
• Open Peer Review

• Sachi Matsubayashi,
• Manabu SuzukiEmail authorView ORCID ID profile,
• Tomoyuki Suzuki,
• Ayako Shiozawa,
• Konomi Kobayashi,
• Satoru Ishii,
• Motoyasu Iikura,
• Shinyu Izumi,
• Koichiro Kudo and
• Haruhito Sugiyama

BMC Pulmonary Medicine201818:138

Open Peer Review reports

Abstract

Background

Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it is suggested to be due to a congenital lymph abnormality. Since YNS is accompanied by chronic bronchial infection in more than half of patients, we hypothesized that treatment with clarithromycin (CAM) could be effective.

Allergic rhinitis and periodontitis among Korean adults: results from a nationwide population-based study (2013–2015)

  BMC Ear, Nose and Throat Disorders201818:12

Eun-Jeong Kim and

Yong-Keum Choi

• Email author

Open Peer Review reports

Abstract

Background

The purpose of this study was to examine whether allergic rhinitis is associated with periodontal disease in a representative sample of elderly Korean people that was adjusted for socio-demographic factors, oral and general health behaviors, and systemic health status.

Seasonal asthma in Melbourne, Australia, and some observations on the occurrence of thunderstorm asthma and its predictability

PLoS One. 2018; 13(4): e0194929.
Jeremy D. Silver,  Michael F. Sutherland, Fay H. Johnston, Edwin R. Lampugnani, Michael A. McCarthy, Stephanie J. Jacobs, Alexandre B. Pezza, and Edward J. Newbigin

Abstract
We examine the seasonality of asthma-related hospital admissions in Melbourne, Australia, in particular the contribution and predictability of episodic thunderstorm asthma.

Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria

Allergy, Asthma & Clinical Immunology

R. Grzanka, A. Damasiewicz-Bodzek and A. Kasperska-Zajac

Allergy, Asthma & Clinical Immunology 2018, 14:27 |

Full Text | PDF Abstract Background Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis.

Dupilumab: A New Paradigm for the Treatment of Allergic Diseases

Sastre J1, Dávila I2

1Allergy Service, Fundación Jiménez Díaz, and Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
2Institute for Biomedical Research of Salamanca (IBSAL), Allergy Service, University Hospital of Salamanca, and Department of Biomedical and Diagnostics Sciences, Faculty of Medicine, Salamanca, Spain

J Investig Allergol Clin Immunol 2018; Vol 28(3) : 139-150
doi: 10.18176/jiaci.0254

• Abstract

Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the therapeutic options are often very limited. Treatment with systemic corticosteroids and immunosuppressants has adverse effects in the long term, and a significant proportion of patients remain refractory to therapy. In this context, the emerging biological drugs constitute a truly innovative therapeutic approach.

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Allergy Asthma Immunol Res. 2018 Jul; 10(4):354-362. English. Published online February 26, 2018.

So-Yeon Lee,1 Eun Lee,2 Yoon Mee Park,3 and Soo-Jong Hong1

Abstract

The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD. PDF