First-reported pediatric cases of American ginseng anaphylaxis and allergy

• Case report
• Open Access

Stephanie C. Erdle,

Edmond S. Chan,

Hyungjun Yang,

Bruce A. Vallance,

Christopher Mill and

Tiffany Wong

• Email author

Allergy, Asthma & Clinical Immunology201814:79

https://doi.org/10.1186/s13223-018-0304-3

Abstract

Background

Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng).

Anaphylactic reaction in patient allergic to mango

Allergy, Asthma & Clinical Immunology

• Case report
• Open Access

• Natalia Ukleja-SokołowskaEmail author,
• Ewa Gawrońska-Ukleja,
• Kinga Lis,
• Magdalena Żbikowska-Gotz,
• Łukasz Sokołowski and
• Zbigniew Bartuzi

Allergy, Asthma & Clinical Immunology201814:78

https://doi.org/10.1186/s13223-018-0294-1

Abstract

Background

An allergy to mango is extremely rare. The antigenic composition of the fruit is not fully known. Profilin from mango has a structure similar to birch tree profiling: it is responsible for cross-reactions between mango and pear, apple, and peach. A panallergen with a structure similar to mugwort defensin (Art v 1) which cross-reacts with celery, carrot, peanuts, pepper, aniseed, and caraway has been previously described.

First reported case in Canada of anaphylaxis to lupine in a child with peanut allergy

Allergy, Asthma & Clinical Immunology



•  Case report
• Open Access

• Lianne Soller,
• Sebastien La Vieille and
• Edmond S. Chan

Allergy, Asthma & Clinical Immunology201814:64

https://doi.org/10.1186/s13223-018-0303-4

Abstract

Background

Lupine is a member of the legume family and is often used in many food products in Europe (e.g. pasta, pizza, sauces, etc.) as a wheat or soy substitute. Lupine cross-reacts with peanut, and cases of allergic reactions to lupine in peanut-allergic patients have been reported in Europe mainly. In contrast, lupine as an ingredient in food products is relatively new to the Canadian market.

The law of food allergy and accommodation in Canadian schools

Allergy, Asthma & Clinical Immunology


• Review
• Open Access

• Blake Murdoch,
• Eric M. Adams and
• Timothy CaulfieldEmail author

Allergy, Asthma & Clinical Immunology201814:67

https://doi.org/10.1186/s13223-018-0273-6

Abstract

Background

There is ongoing controversy surrounding the appropriate standards and limits of accommodation of children with food allergies in schools. We identify and explain how relevant Canadian common law, legislation, constitutional law and human rights policy can inform future school policy around allergy, disability and food bans.

Early IL-10 producing B-cells and coinciding Th/Tr17 shifts during three year grass-pollen AIT

October 2018Volume 36, Pages 475–488

Ulrich M. Zissler1

, 

Constanze A. Jakwerth1

, 

Ferdinand M. Guerth

, 

Lisa Pechtold

, 

Juan Antonio Aguilar-Pimentel

, 

Katharina Dietz

, 

Kathrin Suttner

, 

Guido Piontek

, 

Bernhard Haller

, 

Zuzana Hajdu

, 

Matthias Schiemann

, 

Carsten B. Schmidt-Weber

, 

Adam M. ChakerCorrespondence information about the author Adam M. ChakerEmail the author Adam M. Chaker

Open Access

PlumX Metrics

DOI: https://doi.org/10.1016/j.ebiom.2018.09.016

 |

Article Info

• Abstract

• Full Text
• Images
• References
• Supplemental Materials

• Graphical abstract

Abstract

Background

Allergen-specific immunotherapy (AIT) is a causative treatment in allergic airway disease, comprising long-term allergen administration and requiring three years of treatment. Mechanisms and biomarkers that translate into clinical efficacy remain urgently needed.

The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor

European Journal of Pharmacology

Volume 838, 5 November 2018, Pages 107-111

Full length article

Author links open overlay panelReggieBosmaaJellevan den BoraHenry F.VischeraLuisLabeagabRobLeursa

https://doi.org/10.1016/j.ejphar.2018.09.011

open access

Abstract

Drug-target binding kinetics has recently attracted considerable interest in view of the potential predictive power for in vivo drug efficacy. The recently introduced antihistamine bilastine has a long duration of in vivo drug action, which outlasts pharmacological active bilastine concentrations in blood. To provide a molecular basis for the long duration of action, we explored the kinetics of bilastine binding to the human histamine H1 receptor using [3H]mepyramine binding studies and compared its pharmacodynamics properties to the reference compounds fexofenadine and diphenhydramine, which have a long (60 ± 20 min) and short (0.41 ± 0.1 min) residence time, respectively. Bilastine shows a long drug-target residence time at the H1 receptor (73 ± 5 min) and this results in a prolonged H1 receptor antagonism in vitro (Ca2+ mobilization in Fluo-4 loaded HeLa cells), following a washout of unbound antagonist. Hence, the long residence time of bilastine can explain the observed long duration of drug action in vivo.

Article PDF

Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

• Research
• Open Access

• Yao-Tung Wang†,
• Hsu-Chung Liu†,
• Hui-Chen Chen,
• Yen-Ching Lee,
• Tung-Chou Tsai,
• Hsiao-Ling Chen,
• Hueng-Chuen FanEmail author and
• Chuan-Mu ChenEmail author

†Contributed equally

Allergy, Asthma & Clinical Immunology201814:43

https://doi.org/10.1186/s13223-018-0269-2

Abstract

Background

Allergen-specific immunotherapy (ASIT) has the potential to modify allergic diseases, and it is also considered a potential therapy for allergic asthma. House dust mite (HDM) allergens, a common source of airborne allergen in human diseases, have been developed as an immunotherapy for patients with allergic asthma via the subcutaneous and sublingual routes. Oral immunotherapy with repeated allergen ingestion is emerging as another potential modality of ASIT. The aim of this study was to evaluate the therapeutic efficacy of the oral ingestion of HDM extracts in a murine model of allergic asthma.

Staphylococcus aureus from patients with chronic rhinosinusitis show minimal genetic association between polyp and non-polyp phenotypes

• Research article
• Open Access
• Open Peer Review
• 
  

• • 
    
• • 
    
  Jake Jervis BardyEmail author,
• Derek S Sarovich,
• Erin P Price,
• Eike Steinig,
• Steven Tong,
• Amanda Drilling,
• Judy Ou,
• Sarah Vreugde,
• Peter-John Wormald and
• Alkis J Psaltis

BMC Ear, Nose and Throat Disorders201818:16

https://doi.org/10.1186/s12901-018-0064-1

Open Peer Review reports

Abstract

Background

Staphylococcus aureus has a high prevalence in chronic rhinosinusitis (CRS) patients and is suggested to play a more etiopathogenic role in CRS patients with nasal polyps (CRSwNP), a severe form of the CRS spectrum with poorer surgical outcomes. We performed a microbial genome-wide association study (mGWAS) to investigate whether S. aureus isolates from CRS patients have particular genetic markers associated with CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP).