Subcutaneous immunotherapy induces alterations in monocytes and dendritic cells homeostasis in allergic rhinitis patients

Allergy, Asthma & Clinical Immunology

 
• Research
• Open Access

• Letícia Sousa,
• Carmen Martín-Sierra,
• Celso Pereira,
• Graça Loureiro,
• Beatriz Tavares,
• Susana Pedreiro,
• António Martinho and
• Artur PaivaEmail author

Allergy, Asthma & Clinical Immunology201814:45

https://doi.org/10.1186/s13223-018-0271-8

Abstract

Background

Specific subcutaneous immunotherapy (SCIT) can achieve long-term remission in patients with allergic rhinitis (AR) through complex and still unknown mechanisms. The aim of this study is to evaluate the effect of SCIT over CD16+ and CD16− monocytes, myeloid (mDCs) and plasmacytoid dendritic cells (pDCs) in patients with AR, comparatively to pharmacological standard treatment (non-SIT).

Sweet syndrome: a rare feature of ANCA-associated vasculitis or unusual consequence of azathioprine-induced treatment

Allergy, Asthma & Clinical Immunology


• Case report
• Open Access

• A. U. Arun KumarView ORCID ID profile,
• Mohamed E. Elsayed,
• Ahmed Alghali,
• Alaa A. Ali,
• Husham Mohamed,
• Wael Hussein,
• Catriona Hackett,
• Niamh Leonard and
• Austin G. StackEmail author

Allergy, Asthma & Clinical Immunology201814:46

Abstract

Background

Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANCA) as well as complicate treatment with azathioprine therapy. Azathioprine, a relatively safe immunosuppressive, is frequently used to maintain disease remission in the treatment of ANCA-associated vasculitis.

Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action

Allergy, Asthma & Clinical Immunology                      
• Review
• Open Access 
• Emma Shardlow,
• Matthew Mold and
• Christopher ExleyEmail authorView ORCID ID profile
Allergy, Asthma & Clinical Immunology201814:80
   
Abstract
Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and AdjuPhos®, while the novel aluminium adjuvant used in Gardasil® is a sulphated version of the latter.

Incidence Trends of Atopic Dermatitis in Infancy and Early Childhood in a Nationwide Prescription Registry Study in Norway

Original Investigation 

Dermatology

November 2, 2018

Cathrine H. Mohn, MD¹; Hege Salvesen Blix, MSc, Pharm, PhD²; Jon Anders Halvorsen, MD, PhD³; et alPer Nafstad, MD, PhD^4,5; Morten Valberg, MSc, PhD⁶; Per Lagerløv, MD, PhD¹

Author Affiliations Article Information

JAMA Network Open. 2018;1(7):e184145. doi:10.1001/jamanetworkopen.2018.4145

Key Points

Question  Is the incidence rate of pediatric atopic dermatitis still increasing?

Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia

Original Investigation 

Immunology

November 2, 2018

Sara Barmettler, MD¹; Mei-Sing Ong, PhD²; Jocelyn R. Farmer, MD, PhD¹; et alHyon Choi, MD, DrPH³; Jolan Walter, MD, PhD^4,5

Author Affiliations Article Information

JAMA Netw Open. 2018;1(7):e184169. doi:10.1001/jamanetworkopen.2018.4169

Key Points

Question  In patients receiving rituximab, what are the current rates of screening and recognition of hypogammaglobulinemia, and what are the infectious risks and predictors for increased mortality?

Macrolide antibiotics in the treatment of chronic rhinosinusitis: evidence from a meta-analysis

 
• Vol 10, No 10 (October 2018)

Authors: Shen Shen, Hongfei Lou, Chengshuo Wang, Luo Zhang

Abstract

Background: The purpose of this study was to systematically assess the subjective and objective outcomes of macrolide therapy for chronic rhinosinusitis (CRS).
Methods: PubMed, Embase and Cochrane databases were searched for clinical trials detailing the effects of macrolide therapy in patients with CRS and published up to December 2017. Sino-Nasal Outcome Test (SNOT), endoscopic scores and computed tomography scans (CT) scores were assessed by mean difference (MD) or standardized mean difference (SMD) with 95% confidence interval. Subgroup analyses were performed to evaluate the source of heterogeneity according to study design and geographic locations. I2 metric was used to assess the heterogeneity.

First-reported pediatric cases of American ginseng anaphylaxis and allergy

• Case report
• Open Access

Stephanie C. Erdle,

Edmond S. Chan,

Hyungjun Yang,

Bruce A. Vallance,

Christopher Mill and

Tiffany Wong

• Email author

Allergy, Asthma & Clinical Immunology201814:79

https://doi.org/10.1186/s13223-018-0304-3

Abstract

Background

Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng).

Anaphylactic reaction in patient allergic to mango

Allergy, Asthma & Clinical Immunology

• Case report
• Open Access

• Natalia Ukleja-SokołowskaEmail author,
• Ewa Gawrońska-Ukleja,
• Kinga Lis,
• Magdalena Żbikowska-Gotz,
• Łukasz Sokołowski and
• Zbigniew Bartuzi

Allergy, Asthma & Clinical Immunology201814:78

https://doi.org/10.1186/s13223-018-0294-1

Abstract

Background

An allergy to mango is extremely rare. The antigenic composition of the fruit is not fully known. Profilin from mango has a structure similar to birch tree profiling: it is responsible for cross-reactions between mango and pear, apple, and peach. A panallergen with a structure similar to mugwort defensin (Art v 1) which cross-reacts with celery, carrot, peanuts, pepper, aniseed, and caraway has been previously described.