DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment

Science Translational Medicine

Vol 11, Issue 479 13 February 2019

Ruth Saunders1,*, 

Himanshu Kaul1,2,*,†,‡, 

Rachid Berair1,*, 

Sherif Gonem1, 

Amisha Singapuri1, 

Amanda J. Sutcliffe1, 

Latifa Chachi1, 

Michael S. Biddle1, 

Davinder Kaur1, 

Michelle Bourne1, 

Ian D. Pavord3, 

Andrew J. Wardlaw1, 

Salman H. Siddiqui1, 

Richard A. Kay4,§, 

Bindi S. Brook5, 

Rod H. Smallwood2,|| and 

Christopher E. Brightling1,†,||

 See all authors and affiliations

Science Translational Medicine  13 Feb 2019:
Vol. 11, Issue 479, eaao6451
DOI: 10.1126/scitranslmed.aao6451

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Smoothing out muscle in asthma

Asthma is often treated with drugs that reduce airway inflammation. Saunders et al. now show that fevipiprant, a prostaglandin D2 type 2 receptor antagonist, reduced smooth muscle mass in bronchial biopsies from asthma patients. Computational simulations of an asthmatic airway predicted that this decrease in airway smooth muscle mass was due to both amelioration of inflammation observed in a prior clinical trial together with direct effects on migration of myofibroblasts.

Age distribution and seasonality in acute eosinophilic pneumonia: analysis using a national inpatient database

• Research article
• Open Access
• Open Peer Review
• 
  

BMC Pulmonary Medicine

• Koshi OtaEmail authorView ORCID ID profile,
• Yusuke Sasabuchi,
• Hiroki Matsui,
• Taisuke Jo,
• Kiyohide Fushimi and
• Hideo Yasunaga

BMC Pulmonary Medicine201919:38

Abstract

Background

Acute eosinophilic pneumonia (AEP) is a rare inflammatory lung disease. Previous studies have shown that most patients with AEP are aged 20 to 40 years, whereas several case studies have included older patients with AEP. These studies also suggested that AEP is more prevalent in summer, but they were limited due to their small sample sizes. We therefore investigated the age distribution and seasonality among patients with AEP using a national inpatient database.

Etiology analysis of nonspecific chronic cough in children of 5 years and younger

Chen, Xin, MS*; Peng, Wan-Sheng, MS; Wang, Lei, MS

Section Editor(s): Abdinia., Babak

Medicine: January 2019 - Volume 98 - Issue 3 - p e13910

doi: 10.1097/MD.0000000000013910

Research Article: Observational Study

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This study aims to analyze the etiology of nonspecific chronic cough in children of 5 years and younger, in order to improve the diagnostic and treatment levels of pediatricians for nonspecific chronic cough in young children.

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

• Research article
• Open Access
• Open Peer Review
• 
  

• Veronica Cappa,
• Alessandro Marcon,
• Gianfranco Di Gennaro,
• Liliya Chamitava,
• Lucia Cazzoletti,
• Cristina Bombieri,
• Morena Nicolis,
• Luigi Perbellini,
• Silvia Sembeni,
• Roberto de Marco^,
• Francesco Spelta,
• Marcello Ferrari and
• Maria Elisabetta ZanolinEmail authorView ORCID ID profile

^Deceased

BMC Pulmonary Medicine201919:32

Open Peer Review reports

Abstract

Background and objective

Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).

Patients Allergic to Fish Tolerate Ray Based on the Low Allergenicity of Its Parvalbumin

February 2019 Volume 7, Issue 2, Pages 500–508.e11

Tanja Kalic, MSc

, 

Francoise Morel-Codreanu, MD

, 

Christian Radauer, PhD

, 

Thimo Ruethers, MSc

, 

Aya C. Taki, PhD

, 

Ines Swoboda, PhD

, 

Christiane Hilger, PhD

, 

Karin Hoffmann-Sommergruber, PhD

, 

Markus Ollert, MD, DMSc

, 

Christine Hafner, MD

, 

Andreas L. Lopata, PhD

, 

Martine Morisset, MD, PhD

, 

Heimo Breiteneder, PhDCorrespondence information about the author PhD Heimo BreitenederEmail the author PhD Heimo Breiteneder

, 

Annette Kuehn, PhD

Open Access

PlumX Metrics

DOI: https://doi.org/10.1016/j.jaip.2018.11.011

 

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Background

Clinical reactions to bony fish species are common in patients with allergy to fish and are caused by parvalbumins of the β-lineage. Cartilaginous fish such as rays and sharks contain mainly α-parvalbumins and their allergenicity is not well understood.

IgG4-related disease can present as recurrent spontaneous hemothorax: a case report

BMC Pulmonary Medicine
• Case report
• Open Access
• Open Peer Review

• Junping Fan†,
• Ruie Feng†,
• Xiaomeng Hou,
• Ji Li,
• Xuefeng Sun,
• Jinglan Wang,
• Juhong Shi,
• Mengzhao Wang and
• Yan XuEmail author

†Contributed equally

BMC Pulmonary Medicine201919:26

Abstract

Background

Immunoglobulin G4-related disease (IgG4-RD) encompasses a group of immune-mediated disorders that are gaining increasing recognition.

Anaphylaxis to intravenous gelatin‐based solutions: a case series examining clinical features and severity

Original Article 

 

Free Access

S. Farooque 

 

M. Kenny 

 

S. D. Marshall

74(2) 174-179, 2019

Summary

The proportion of patients receiving intravenous gelatin‐based colloids has increased in the last decade due to safety concerns about starch‐based products. Recent research suggests hypersensitivity reactions to intravenous gelatin‐based solutions occur at similar rates per administration as non‐depolarising neuromuscular blocking agents such as rocuronium (6.2/100,000 administrations).