Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria

Allergy, Asthma & Clinical Immunology
•   Research
• Open Access
• 
  

• R. Grzanka,
• A. Damasiewicz-Bodzek and
• A. Kasperska-ZajacEmail authorView ORCID ID profile

Allergy, Asthma & Clinical Immunology201915:15

Abstract

Background

There is increasing evidence pointing to the important role of tumor necrosis factor-alpha (TNF-α), a key inflammatory and apoptotic mediator in urticarial inflammation. However, the role of the TNF-α system and Fas/Fas ligand (FasL) in the apoptosis-inducing pathways in chronic spontaneous urticaria (CSU), remain unclear.

Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients

• Original research article
• Open Access

Martina Sterclova

,

Magdalena Smetakova,

Ludek Stehlik,

Jelena Skibova and

Martina Vasakova

Multidisciplinary Respiratory Medicine201914:13

Abstract

Background

Extrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4Rα concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied.

Indirect comparison of intravenous vs. subcutaneous C1-inhibitor placebo-controlled trials for routine prevention of hereditary angioedema attacks

Allergy, Asthma & Clinical Immunology
• Research
• Open Access

• Jonathan A. BernsteinEmail author,
• Huamin Henry Li,
• Timothy J. Craig,
• Michael E. Manning,
• John-Philip Lawo,
• Thomas Machnig,
• Girishanthy Krishnarajah and
• Moshe Fridman

Allergy, Asthma & Clinical Immunology201915:13

Abstract

Introduction

For prophylaxis of hereditary angioedema (HAE) attacks, replacement therapy with human C1-inhibitor (C1-INH) treatment is approved and available as intravenous [C1-INH(IV)] (Cinryze®) and subcutaneous [C1-INH(SC)] HAEGARDA®preparations. In the absence of a head-to-head comparative study of the two treatment modalities, an indirect comparison of data from 2 independent but similar clinical trials was undertaken.

• Meeting abstracts
• Open Access

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018

Allergy, Asthma & Clinical Immunology201915 (Suppl 1) :10

1. Allergic Rhinitis/Asthma
2. Immunology
3. FOOD ALLERGY/ANAPHYLAXIS
4. OTHER ALLERGY/IMMUNOLOGY
5. CASE REPORT
6. ALLIED HEALTH
7. Declarations

1. 
   

World Allergy Organization Journal New articles available on ScienceDirect

World Allergy Organization Journal

New articles available on ScienceDirect

World Allergy Organization Journal Volume 12, Issue 1, Pages , 2019 Under-diagnosis of atopic dermatitis in Puerto Rican children Page 100003 Available Online 2019-01-26 Ge Yang, Yueh-Ying Han, Erick Forno, Edna Acosta-Pérez, Angel Colón-Semidey, María Alvarez, Glorisa Canino, Wei Chen, Juan C. Celedón Validation of the Turkish version of the Urticaria Control Test: Correlation with other tools and comparison between spontaneous and inducible chronic urticaria Page 100009 Available Online 2019-01-26 Emek Kocatürk, Utkan Kızıltaç, Pelin Can, Rabia Öztaş Kara, Teoman Erdem, Kübra Kızıltaç, Nagihan Sahillioğlu, Aslı Gelincik, Marcus Maurer, Karsten Weller

Electronic Clinical Decision Support System for allergic rhinitis management: MASK e‐CDSS

ORIGINAL ARTICLE 

 

Free Access

Anne‐Lise Courbis 

 

Ruth Brigid Murray 

 

Sylvie Arnavielhe 

 

Davide Caimmi 

 

Anna Bedbrook 

 

Michiel Van Eerd 

 

Govert De Vries 

 

Gerard Dray 

 

Ioana Agache 

 

Mario Morais‐Almeida 

… See all authors 

https://doi.org/10.1111/cea.13230

 

Cited by: 3

Summary

Background

Allergic rhinitis (AR) management has changed in recent years following the switch from the concept of disease severity to the concept of disease control, publication of the AR clinical decision support system (CDSS) and development of mobile health (m‐health) tools for patients (eg Allergy Diary). The Allergy Diary Companion app for healthcare providers is currently being developed and will be launched in 2018.

World Allergy Congress December 12-14, 2019 - Lyon, France DISCOVER OUR PLENARY SESSIONS!

World Allergy Congress December 12-14, 2019 - Lyon, France DISCOVER OUR PLENARY SESSIONS!     Pathways leading to atopic diseases and atopic multimorbidity       Florence Demenais (France)   New risk loci associated with atopic multimorbidity   MORE   Adnan Custovic (UK)   Atopic Phenotype and their implication in the atopic march   MORE   Erik Melen (Sweden)   Mechanisms underlying allergy and asthma at a molecular level: results from MeDALL studies   MORE

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype

RESEARCH ARTICLEALLERGY

1. Donald Y. M. Leung1,*, 
2. Agustin Calatroni2, 
3. Livia S. Zaramela3, 
4. Petra K. LeBeau2, 
5. Nathan Dyjack1, 
6. Kanwaljit Brar1, 
7. Gloria David2, 
8. Keli Johnson2, 
9. Susan Leung1, 
10. Marco Ramirez-Gama1, 
11. Bo Liang3, 
12. Cydney Rios1, 
13. Michael T. Montgomery1, 
14. Brittany N. Richers1, 
15. Clifton F. Hall1, 
16. Kathryn A. Norquest1, 
17. John Jung1, 
18. Irina Bronova1, 
19. Simion Kreimer4, 
20. C. Conover Talbot Jr.4, 
21. Debra Crumrine5, 
22. Robert N. Cole4, 
23. Peter Elias5, 
24. Karsten Zengler3, 
25. Max A. Seibold1, 
26. Evgeny Berdyshev1 and 
27. Elena Goleva1

 See all authors and affiliations

Science Translational Medicine  20 Feb 2019:
Vol. 11, Issue 480, eaav2685
DOI: 10.1126/scitranslmed.aav2685

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Digging skin deep

Disrupted epithelial barriers are thought to be central to development of allergic disorders such as atopic dermatitis, which is commonly associated with food allergy. Leung et al. performed repeated skin tape stripping on lesional and nonlesional skin of patients with pediatric atopic dermatitis, some of whom also had food allergies. Among other parameters, they measured lipids, proteins, barrier integrity, and the microbiome. They found that nonlesional skin from patients with atopic dermatitis had different characteristics depending on whether the patient also had food allergy. Gene expression analysis also showed elevated type 2 immune signatures in food allergic samples. Their findings reveal unique properties about the epidermis in allergic disease and could lead to the development of biomarkers for food allergy.

Abstract

Skin barrier dysfunction has been reported in both atopic dermatitis (AD) and food allergy (FA). However, only one-third of patients with AD have FA.