Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Int Arch Allergy Immunol. 2019 Mar 15:1-10. doi: 10.1159/000497160. [Epub ahead of print] 
Karaulov AV, Vylegzhanina T, Ovchinnikov A, Chernikova M, Nenasheva N.

Abstract

BACKGROUND: Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR). Triamcinolone acetonide is a nasal corticosteroid preparation indicated for the treatment of seasonal and perennial AR (PAR) in different countries worldwide.

The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods

Pediatrics

April 2019, VOLUME 143 / ISSUE 4

From the American Academy of Pediatrics

Clinical Report

Frank R. Greer, Scott H. Sicherer, A. Wesley Burks, COMMITTEE ON NUTRITION, SECTION ON ALLERGY AND IMMUNOLOGY

 Abstract

This clinical report updates and replaces a 2008 clinical report from the American Academy of Pediatrics, which addressed the roles of maternal and early infant diet on the prevention of atopic disease, including atopic dermatitis, asthma, and food allergy. As with the previous report, the available data still limit the ability to draw firm conclusions about various aspects of atopy prevention through early dietary interventions. Current evidence does not support a role for maternal dietary restrictions during pregnancy or lactation. Although there is evidence that exclusive breastfeeding for 3 to 4 months decreases the incidence of eczema in the first 2 years of life, there are no short- or long-term advantages for exclusive breastfeeding beyond 3 to 4 months for prevention of atopic disease. The evidence now suggests that any duration of breastfeeding ≥3 to 4 months is protective against wheezing in the first 2 years of life, and some evidence suggests that longer duration of any breastfeeding protects against asthma even after 5 years of age. No conclusions can be made about the role of breastfeeding in either preventing or delaying the onset of specific food allergies. There is a lack of evidence that partially or extensively hydrolyzed formula prevents atopic disease. There is no evidence that delaying the introduction of allergenic foods, including peanuts, eggs, and fish, beyond 4 to 6 months prevents atopic disease. There is now evidence that early introduction of peanuts may prevent peanut allergy.

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European S2k Guideline on Chronic Pruritus

Vol 99, Issue 5, 469-506, 2019

Elke Weisshaar, Jacek C. Szepietowski, Florence J. Dalgard, Simone Garcovich, Uwe Gieler, Ana M. Giménez-Arnau, Julien Lambert, Tabi Leslie, Thomas Mettang, Laurent Misery, Ekin Şavk, Markus Streit, Erwin Tschachler, Erwin Tschachler, Joanna Wallengren, Sonja Ständer
DOI: 10.2340/00015555-3164 

Abstract

Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Pruritus may be the result of a dermatological or non-dermatological disease. Especially in non-diseased skin it may be caused by systemic, neurological or psychiatric diseases, as well as being a side effect of medications. In a number of cases chronic pruritus may be of multifactorial origin. Pruritus needs a precise diagnostic work-up. Management of chronic pruritus comprises treatment of the underlying disease and topical treatment modalities, including symptomatic antipruritic treatment, ultraviolet phototherapy and systemic treatment. Treating chronic pruritus needs to be targeted, multimodal and performed in a step-wise procedure requiring an interdisciplinary approach. We present the updated and consensus based (S2k) European guideline on chronic pruritus by a team of European pruritus experts from different disciplines. This version is an updated version of the guideline that was published in 2012 and updated in 2014 (www.euroderm.org).

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Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens

Pall, Brian, OD, MS*; Gomes, Paul, MS†; Yi, Frank, MS*; Torkildsen, Gail, MD‡

Cornea: March 19, 2019 - Volume Publish Ahead of Print - Issue - p

doi: 10.1097/ICO.0000000000001911

Clinical Science: PDF Only

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SDC

PAP

• Abstract
• 
  

Purpose: A contact lens (CL)-based drug delivery system for therapeutic delivery of the antihistamine ketotifen was tested in 2 parallel, conjunctival allergen challenge-based trials.

Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies

Allergy, Asthma & Clinical Immunology
 
• Case report
• Open Access

• Mongkhon SompornrattanaphanEmail author,
• Piyawut Kreetapirom,
• Yuttana Srinoulprasert,
• Duangjit Kanistanon,
• Anchalika Klinniyom,
• Chamard Wongsa and
• Torpong Thongngarm

Allergy, Asthma & Clinical Immunology201915:19

https://doi.org/10.1186/s13223-019-0335-4

Abstract

Background

Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions.

World Allergy Congress Lyon 2019 : Novel therapies in skin allergic diseases.

FOCUS ON OUR PLENARY SESSIONS

“Novel therapies in skin allergic diseases”   Atopic dermatitis (AD) is the most prevalent skin allergy. Not surprisingly, there has been increasing interest in developing experimental approaches to study the pathogenesis of human AD in vivo, in vitro, and in silico to better define pathophysiologic mechanisms and identify novel therapeutic targets and biomarkers that predict therapeutic response.

Physician Confidence in Artificial Intelligence: An Online Mobile Survey

Original Paper

• Songhee Oh¹, MD ; 
• Jae Heon Kim², MD ; 
• Sung-Woo Choi³, MD ; 
• Hee Jeong Lee¹, MD ; 
• Jungrak Hong⁴, MD ; 
• Soon Hyo Kwon¹, MD 

¹Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Republic of Korea

²Department of Urology, Soonchunhyang University Hospital, Seoul, Republic of Korea

³Department of Orthopedic Surgery, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea

⁴Department of Internal Medicine, New York Medical College, New York Health Hospital, New York, NY, United States

ABSTRACT

Background: It is expected that artificial intelligence (AI) will be used extensively in the medical field in the future.

Objective: The purpose of this study is to investigate the awareness of AI among Korean doctors and to assess physicians’ attitudes toward the medical application of AI.

The Allergic Rhinitis Control Test Questionnaire Is Valuable in Guiding Step-Down Pharmacotherapy Treatment of Allergic Rhinitis

The Journal of Allergy and Clinical Immunology: In Practice

Volume 7, Issue 1, January 2019, Pages 272-278

Background
Allergic Rhinitis Control Test (ARCT) has been validated in the allergic rhinitis (AR) step-up pharmacotherapy management approach.
Objective
The aim of our study was to evaluate the potential of ARCT in AR step-down pharmacotherapy.