Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis

Clinical and Translational Allergy 
•   Research
• Open Access

• Lien Calus,
• Nicholas Van Bruaene,
• Cedric Bosteels,
• Sarah Dejonckheere,
• Thibaut Van Zele,
• Gabrielle Holtappels,
• Claus Bachert and
• Philippe GevaertEmail authorView ORCID ID profile

Clinical and Translational Allergy20199:30

Abstract

Background

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical treatment. We monitored recurrence and revision surgery over 12 years after endoscopic sinus surgery in CRSwNP patients.

Methods

In this prospective cohort study, 47 patients with CRSwNP, who underwent primary or revision extended endoscopic sinus surgery, were followed. Clinical symptoms and total nasal endoscopic polyp score were evaluated before, 6 years and 12 years after surgery.

Results

Fig. 1 Symptoms, expressed as no, mild, moderate or severe are shown as the percentage of study population that experience complaints with the respective severity, at each time point (2000 N = 47, 2006 N = 27 and 2012 N = 24). The percentages are marked in the bars. **P < 0.01; ***P < 0.001

CME / ABIM MOC / CE Is Peanut Oral Immunotherapy Safe to Treat Allergies?

CME / ABIM MOC / CE

Is Peanut Oral Immunotherapy Safe to Treat Allergies?

• Authors: News Author: Jennifer Garcia; CME Author: Charles P. Vega, MD
• CME / ABIM MOC / CE Released: 6/7/2019
• Valid for credit through: 6/7/2020

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Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors

REVIEW ARTICLE

Front. Immunol., 03 April 2019 | https://doi.org/10.3389/fimmu.2019.00673

Isabel J. Skypala*

• Department of Allergy and Clinical Immunology, Imperial College, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom

Abstract: Food anaphylaxis is on the increase, with those who have an allergy to peanuts, tree nuts, milk, and seafood at the highest risk of developing such a reaction. However, the diet in many societies is increasingly varied, much of the food consumed is prepared outside the home, and meals are often composed of many different ingredients.

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

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Clinical Allergy – Research Article

Editor's Choice - Free Access

Li Y.a · Rui X.a · Ma B.b · Jiang F.c,d · Chen J.a

Int Arch Allergy Immunol 2019;178:323–332

https://doi.org/10.1159/000495304

• Abstract
• FullText
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• Extras : 7

 

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Abstract

Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR). 

SCIT Versus SLIT: Which One Do You Recommend, Doc?

Special FeaturePatient-Centered Focused ReviewSCIT Versus SLIT: Which One Do You Recommend, Doc?Author links open overlay panel

Mohamad R.ChaabanMD, MSCR, MBA1AhmedMansiBSc2Julia W.TrippleMD3Sarah K.WiseMD4

The American Journal of the Medical Sciences

Volume 357, Issue 5, May 2019, Pages 442-447

Abstract

Allergic rhinitis is a prevalent condition that has a significant impact on the quality of life of many patients. When initial therapy fails to control the symptoms, allergen immunotherapy (AIT) has been suggested as an option by the Joint Task Force on Practice Parameters.

The 2 main forms of AIT are via subcutaneous and sublingual routes, called subcutaneous immunotherapy and sublingual immunotherapy, respectively. There is debate about which is the better option for patients with each method offering its own pros and cons.

Bradykinin sensitizes the cough reflex via a B2receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

Respiratory Research
•     Research
• Open Access

• Fajer Al-Shamlan and
• Ahmed Z. El-HashimEmail authorView ORCID ID profile

Respiratory Research201920:110

https://doi.org/10.1186/s12931-019-1060-8

Abstract

Background

Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the cough reflex and in airway obstruction.

Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough

Respiratory Research
•    Research
• Open Access

• Li Long†,
• Hongmei Yao†,
• Jing Tian†,
• Wei Luo,
• Xinxin Yu,
• Fang Yi,
• Qiaoli Chen,
• Jiaxing Xie,
• Nanshan Zhong†,
• Kian Fan Chung† and
• Kefang Lai†Email author

†Contributed equally

Respiratory Research201920:112

https://doi.org/10.1186/s12931-019-1077-z

Abstract

Background

The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood. We investigated the phenotypes of cough hypersensitivity by examining transient receptor potential ankyrin 1 (TRPA1)- and transient receptor potential vanilloid 1 (TRPV1)-mediated cough sensitivity in patients with chronic refractory cough.

Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis

Clinical and Translational Allergy 
•   Review
• Open Access

• Ralph Mösges†,
• Antonio Valero Santiago†,
• Silke Allekotte,
• Nilufar Jahed,
• Anatoli Astvatsatourov,
• Angelika Sager and
• Jaime Sánchez-LópezEmail authorView ORCID ID profile

†Contributed equally

Clinical and Translational Allergy20199:29

https://doi.org/10.1186/s13601-019-0268-5

Abstract

Background

Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates the efficacy of AIT using different allergens in different severity stages of rhinoconjunctivitis with or without asthma in the pollen studies and asthma and rhinitis in the house dust mite studies in comparison to placebo.