Regulatory roles of IL-10–producing human follicular T cells

 View ORCID ProfilePablo F. Cañete, Rebecca A. Sweet, Paula Gonzalez-Figueroa, Ilenia Papa, Naganari Ohkura, Holly Bolton, Jonathan A. Roco, Marta Cuenca, Katharine J. Bassett, Ismail Sayin, Emma Barry, View Angel Lopez, David H. Canaday, Michael Meyer-Hermann, Claudio Doglioni, Barbara Fazekas de St Groth, Shimon Sakaguchi, Matthew C. Cook, Carola G. Vinuesa Correspondence email

DOI: 10.1084/jem.20190493 | Published June 17, 2019

Abstract

Mucosal lymphoid tissues such as human tonsil are colonized by bacteria and exposed to ingested and inhaled antigens, requiring tight regulation of immune responses. Antibody responses are regulated by follicular helper T (TFH) cells and FOXP3+ follicular regulatory T (TFR) cells. Here we describe a subset of human tonsillar follicular T cells identified by expression of TFH markers and CD25 that are the main source of follicular T (TF) cell–derived IL-10. Despite lack of FOXP3 expression, CD25+ TF cells resemble T reg cells in high CTLA4 expression, low IL-2 production, and their ability to repress T cell proliferation. CD25+ TF cell–derived IL-10 dampens induction of B cell class-switching to IgE. In children, circulating total IgE titers were inversely correlated with the frequencies of tonsil CD25+ TF cells and IL-10–producing TF cells but not with total T reg cells, TFR, or IL-10–producing T cells. Thus, CD25+ TF cells emerge as a subset with unique T and B cell regulatory activities that may help prevent atopy.

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Characteristics of patients admitted to emergency department for asthma attack: a real-LIFE study

• Research article
• Open Access
• Open Peer Review
• BMC Pulmonary Medicine

• Laura Losappio,
• Enrico Heffler,
• Rossella Carpentiere,
• Monica Fornero,
• Cosimo Damiano Cannito,
• Francesco Guerrera,
• Francesca Puggioni,
• Riccardo Monti,
• Stefania Nicola,
• Giovanni Rolla and
• Luisa BrussinoEmail authorView ORCID ID profile

BMC Pulmonary Medicine201919:107

Abstract

Background

Asthma is a chronic disease affecting 30 million people in Europe under 45y. Poor control of Asthma is the main cause of emergency-department (ED) access, becoming the strongest determinant of the economic burden of asthma management.

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis

Clinical and Translational Allergy 
•   Research
• Open Access

• Lien Calus,
• Nicholas Van Bruaene,
• Cedric Bosteels,
• Sarah Dejonckheere,
• Thibaut Van Zele,
• Gabrielle Holtappels,
• Claus Bachert and
• Philippe GevaertEmail authorView ORCID ID profile

Clinical and Translational Allergy20199:30

Abstract

Background

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical treatment. We monitored recurrence and revision surgery over 12 years after endoscopic sinus surgery in CRSwNP patients.

Methods

In this prospective cohort study, 47 patients with CRSwNP, who underwent primary or revision extended endoscopic sinus surgery, were followed. Clinical symptoms and total nasal endoscopic polyp score were evaluated before, 6 years and 12 years after surgery.

Results

Fig. 1 Symptoms, expressed as no, mild, moderate or severe are shown as the percentage of study population that experience complaints with the respective severity, at each time point (2000 N = 47, 2006 N = 27 and 2012 N = 24). The percentages are marked in the bars. **P < 0.01; ***P < 0.001

CME / ABIM MOC / CE Is Peanut Oral Immunotherapy Safe to Treat Allergies?

CME / ABIM MOC / CE

Is Peanut Oral Immunotherapy Safe to Treat Allergies?

• Authors: News Author: Jennifer Garcia; CME Author: Charles P. Vega, MD
• CME / ABIM MOC / CE Released: 6/7/2019
• Valid for credit through: 6/7/2020

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Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors

REVIEW ARTICLE

Front. Immunol., 03 April 2019 | https://doi.org/10.3389/fimmu.2019.00673

Isabel J. Skypala*

• Department of Allergy and Clinical Immunology, Imperial College, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom

Abstract: Food anaphylaxis is on the increase, with those who have an allergy to peanuts, tree nuts, milk, and seafood at the highest risk of developing such a reaction. However, the diet in many societies is increasingly varied, much of the food consumed is prepared outside the home, and meals are often composed of many different ingredients.

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

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Clinical Allergy – Research Article

Editor's Choice - Free Access

Li Y.a · Rui X.a · Ma B.b · Jiang F.c,d · Chen J.a

Int Arch Allergy Immunol 2019;178:323–332

https://doi.org/10.1159/000495304

• Abstract
• FullText
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• References
• Extras : 7

 

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Abstract

Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR). 

SCIT Versus SLIT: Which One Do You Recommend, Doc?

Special FeaturePatient-Centered Focused ReviewSCIT Versus SLIT: Which One Do You Recommend, Doc?Author links open overlay panel

Mohamad R.ChaabanMD, MSCR, MBA1AhmedMansiBSc2Julia W.TrippleMD3Sarah K.WiseMD4

The American Journal of the Medical Sciences

Volume 357, Issue 5, May 2019, Pages 442-447

Abstract

Allergic rhinitis is a prevalent condition that has a significant impact on the quality of life of many patients. When initial therapy fails to control the symptoms, allergen immunotherapy (AIT) has been suggested as an option by the Joint Task Force on Practice Parameters.

The 2 main forms of AIT are via subcutaneous and sublingual routes, called subcutaneous immunotherapy and sublingual immunotherapy, respectively. There is debate about which is the better option for patients with each method offering its own pros and cons.

Bradykinin sensitizes the cough reflex via a B2receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

Respiratory Research
•     Research
• Open Access

• Fajer Al-Shamlan and
• Ahmed Z. El-HashimEmail authorView ORCID ID profile

Respiratory Research201920:110

https://doi.org/10.1186/s12931-019-1060-8

Abstract

Background

Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the cough reflex and in airway obstruction.