Risk factors for severe systemic sting reactions in wasp (Vespula spp.) and honeybee (Apis mellifera) venom allergic patients

• Clinical and Translational Allergy Research Open Access

• Danielle Fehr, 
• Sara Micaletto, 
• Thomas Moehr & 
• Peter Schmid-Grendelmeier 

Clinical and Translational Allergy volume 9, Article number: 54 (2019) | 

Abstract

Frequency of grades according to each insect

Background

Hymenoptera stings are a major cause of anaphylaxis. Various risk factors are discussed in literature. This study aims to investigate potential risk factors for severe sting reactions in wasp (Vespula spp.) and honeybee (Apis mellifera) venom allergic patients and analyses the correlation between diagnostic test results and the severity of the allergic reaction.

Clinically relevant effect of rupatadine 20 mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis

• Clinical and Translational Allergy
• Research
• Open Access
• 
  

• Joaquim Mullol, 
• Iñaki Izquierdo, 
• Kimihiro Okubo, 
• Giorgio Walter Canonica, 
• Jean Bousquet & 
• Antonio Valero 

Clinical and Translational Allergy volume 9, Article number: 50 (2019) 

Abstract

Background

Different clinical trials showed the superior efficacy of rupatadine compared to placebo at improving seasonal allergic rhinitis (SAR) symptoms, but no study has assessed if the response promoted is clinically meaningful.

Clinical Utility Of The Exhaled Nitric Oxide (NO) Measurement With Portable Devices In The Management Of Allergic Airway Inflammation And Asthma

Journal of Asthma and Allergy

Volume 2019:12 Pages 331—341

DOI https://doi.org/10.2147/JAA.S190489

Sy Duong-Quy<sup>1,2

1</sup>Department of Respiratory Diseases, Medical and Biological Research Centre, Lam Dong Medical College, Dalat City, Lam Dong Province, Vietnam; ²Department of Immuno-Allergology, Penn State Medical College, Hershey, PA, USA

Abstract: Nitric oxide (NO) is a potential bioactive gas produced continuously and constantly in the airways of healthy subjects. In allergic airway inflammation, the level of exhaled NO is usually increased and mediated by inducible nitric oxide synthase (iNOS) enzyme presenting in the epithelium and different inflammatory cells. The measurement of NO concentration in the airway is possible with portable devices which use an electroluminescence technique. In subjects with upper airway with allergic inflammation such as in allergic rhinitis, the measurement of nasal NO (nNO) may help to diagnose and manage the disease. In the lower airway, increased fractional exhaled NO (FENO) reflects directly the inflammatory process that occurs in the airways that are typically seen in asthma.

Origin of nasal NO and technique of nNO measurement.
Exhaled NO is produced from the epithelial cells, eosinophils,
 mast cells, and other cells under the activity of iNOS
 during contact with allergens. The measurement of nNO
is done by introducing the sampling catheter to the nasal
cavity via the nostril to aspirate the internal air stream. 

It has been shown that there is a strong correlation between FENO levels and increased activity of airway inflammation mediated by immuno-allergic cells and mediators. Thus, FENO has higher specificity and sensitivity than other methods in diagnosing the severity of inflammation in asthmatic patients. Moreover, the correlation between increased FENO levels and a high risk of bronchial hyperresponsiveness has also been demonstrated. FENO is also a relevant biomarker to evaluate asthma status due to the change of its values occurring earlier than clinical manifestations and spirometry parameters. In addition, the measurement of FENO with portable devices helps to support the diagnosis of asthma, to follow-up the control of asthma and to personalize asthmatic patients for target treatment with biologic therapy. Therefore, measuring FENO with portable devices in the diagnosis and treatment of allergic airway inflammation, especially in asthma, is one of the most essential applications of NO biomarkers in exhaled breath.

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Myths, facts and controversies in the diagnosis and management of anaphylaxis

Review

Katherine Anagnostou, Paul J Turner

Abstract

Anaphylaxis is a serious systemic allergic reaction that is rapid in onset and may cause death. Despite numerous national and international guidelines and consensus statements, common misconceptions still persist in terms of diagnosis and appropriate management, both among healthcare professionals and patient/carers. We address some of these misconceptions and highlight the optimal approach for patients who experience potentially life-threatening allergic reactions.

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CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria

• Review
• Open Access

• Allergy, Asthma & Clinical Immunology

• Michael N. Fein, 
• David A. Fischer, 
• Andrew W. O’Keefe & 
• Gord L. Sussman 

Allergy, Asthma & Clinical Immunologyvolume 15, Article number: 61 (2019)  

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Abstract

Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side effects including sedation, impairment with decreased cognitive function, poor sleep quality, dry mouth, dizziness, and orthostatic hypotension. These drugs have also been found to result in death from accidents, intentional or unintentional overdoses, and sudden cardiac death.

Indoor exposure to particulate matter and volatile organic compounds in dwellings and workplaces and respiratory health in French farmers

• Original research article
• Open Access
• 
  

• Cara Nichole Maesano, 
• Denis Caillaud, 
• Hassani Youssouf, 
• Soutrik Banerjee, 
• Julie Prud’Homme, 
• Christelle Audi, 
• Kigninlman Horo, 
• Yacouba Toloba, 
• Ollivier Ramousse & 
• Isabella Annesi-Maesano 

Multidisciplinary Respiratory Medicinevolume 14, Article number: 33 (2019) | 

Abstract

Introduction

Few investigations have related objective assessments of indoor air pollutants to respiratory health in farmers, in spite of the many rural environmental hazards to which they are exposed. Chemical air pollution has been particularly neglected.

Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications

REVIEW

          

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Authors Puxeddu I, Petrelli F, Angelotti F, Croia C, Migliorini P

 Journal of Asthma and Allergy Volume 2019:12 Pages 285—295

DOI https://doi.org/10.2147/JAA.S184986

Abstract: Chronic urticaria (CU) is a mast cell-driven disease characterized by the development of wheals, angioedema, or both for more than 6 weeks. The two major sub-types are chronic spontaneous urticaria (CSU) and inducible urticaria. In the last decade different pathophysiological mechanisms, potentially responsible for the development of the disease, have been described.

Engaging and Educating Patients to Improve AD Care: A Practical Toolkit for Clinical Teams

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• ACTIVITY OVERVIEW

Intended Audience: Physicians, Nurse Practitioners, Physician Assistants, and Nurses

Did you know that patients who learn about their own health conditions and partner with their clinical teams to decide on the best treatments are much happier and achieve better outcomes with their care?

This inclusive guide provides clinicians with materials and resources to engage and educate patients, individually or through group education, about atopic dermatitis (AD) and help build a strong foundation for informed decision-making regarding treatment goals, preferences, and plans.

Included in this guide: