December 7, 2020

Penicillin and cephalosporin cross-reactivity: role of side chain and synthetic cefadroxil epitopes

  • Research
  • Open Access

Clinical and Translational Allergy

Abstract

Background

Analysis of cross-reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam most often involved in immediate hypersensitivity reactions (IHRs), and cefadroxil (CX) the most likely cephalosporin to cross-react with AX, since they share the same R1 side chain, unlike cefuroxime (CO), with a structurally different R1. We aimed to analyse cross-reactivity with CX and CO in patients with confirmed IHRs to AX, including sIgE recognition to AX, CX, CO, and novel synthetic determinants of CX.

November 25, 2020

World Allergy Organization Journal Volume 13, Issue 11 , November 2020

Alert: World Allergy Organization Journal

New Articles available on ScienceDirect

Cover Image World Allergy Organization Journal

World Allergy Organization Journal

Volume 13, Issue 11 , November 2020

The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study

Article Number 100475

Marcus Maurer, Karsten Weller, Markus Magerl, Rasmus Robin Maurer, Emanuel Vanegas, Miguel Felix, Annia Cherrez, Valeria L. Mata, Alicja Kasperska-Zajac, Agnieszka Sikora, Daria Fomina, Elena Kovalkova, Kiran Godse, Nimmagadda Dheeraj Rao, Maryam Khoshkhui, Sahar Rastgoo, Roberta Fachini Jardim Criado, Mohamed Abuzakouk, Deepa Grandon, Martijn van Doorn

A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia

Article Number 100477

Yu Ting Ng, Fook Tim Chew

November 18, 2020

Predominant patterns of β-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins

  • Research
  • Open Access

Allergy, Asthma & Clinical Immunology

Abstract

Background
Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsistent. We aimed to determine patterns of β-latam allergy, i.e. the association of a clinical reaction type with a specific β-lactam antibiotic.

November 16, 2020

Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management

  • Case Report
  • Open Access
Abstract
Background

Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, such as the measles, mumps, and rubella (MMR) vaccine, is regarded (erroneously) as potentially dangerous or even anaphylactogenic, by many. An issue perceived as particularly conflicting also by Health Professionals.

November 11, 2020

Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology

volume Allergy, Asthma & Clinical Immunology 16, Article number: 95 (2020

Abstract

The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public health. This article provides an overview of beta-lactam allergy, implications of erroneous beta-lactam allergy labels and the impact that can be provided by structured allergy assessment. We provide recommendations on how to stratify risk of beta-lactam allergy, beta lactam challenge protocols as well as management of patients at high risk of beta-lactam allergy.


November 4, 2020

A single centre retrospective study of systemic reactions to subcutaneous immunotherapy

  • Research
  • Open Access

Allergy, Asthma & Clinical Immunology

Background

Subcutaneous immunotherapy (SCIT) is the standard approach for treating patients with sensitizations to aeroallergens. However, immunotherapy can trigger severe systemic reactions if delivered inappropriately or to high risk patients. We sought to characterize and quantify SCIT systemic reactions requiring epinephrine administration during a 6-year period in a Canadian setting following the recommendations for components and dosages published in the 2010 Canadian Society of Allergy and Clinical Immunology (CSACI) Immunotherapy Manual.

Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic

  • Research
  • Open Access

Background

An increase in online searches on health topics may either mirror epidemiological changes or reflect media coverage. In the context of COVID-19, this is particularly relevant, as COVID-19 symptoms may be mistaken for those of respiratory disease exacerbations. Therefore, we aimed to assess Internet search patterns on asthma and chronic obstructive pulmonary disease (COPD) in the context of COVID-19, as compared to searches on other chronic diseases.