Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

• Review
• Open Access
• 
  

• Jean Bousquet, 
• Jean-Paul Cristol, 
• Wienczyslawa Czarlewski, 
• Josep M. Anto, 
• Adrian Martineau, 
• Tari Haahtela, 
• Susana C. Fonseca, 
• Guido Iaccarino, 
• Hubert Blain, 
• Alessandro Fiocchi, 
• G. Walter Canonica, 
• Joao A. Fonseca, 
• Alain Vidal, 
• Hak-Jong Choi, 
• Hyun Ju Kim, 
• Vincent Le Moing, 
• Jacques Reynes, 
• Aziz Sheikh, 
• Cezmi A. Akdis, 
• Torsten Zuberbier & 
• the ARIA group

Clinical and Translational Allergy volume 10, Article number: 58 (2020) 

Abstract

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm.

First pediatric electronic algorithm to stratify risk of penicillin allergy

• Letter to the editor
• Open Access
• 
  

Allergy, Asthma & Clinical Immunology

• Hannah Roberts, 
• Lianne Soller, 
• Karen Ng, 
• Edmond S. Chan, 
• Ashley Roberts, 
• Kristopher Kang, 
• Kyla J. Hildebrand & 
• Tiffany Wong 

Allergy, Asthma & Clinical Immunology volume 16, Article number: 103 (2020) 

Abstract

Beta-lactam allergy is reported in 5–10% of children in North America, but up to 94–97% of patients are deemed not allergic after allergist assessment. The utility of standardized skin testing for penicillin allergy in the pediatric population has been recently questioned. Oral drug challenges when appropriate, are preferred over skin testing, and can definitively rule out immediate, IgE-mediated drug allergy. To our knowledge, this is the only pediatric study to assess the reliability of a penicillin allergy stratification tool using a paper and electronic clinical algorithm.

Penicillin and cephalosporin cross-reactivity: role of side chain and synthetic cefadroxil epitopes

• Research
• Open Access
• 
  

Clinical and Translational Allergy

• Gador Bogas, 
• Cristobalina Mayorga, 
• Ángela Martín-Serrano, 
• Rubén Fernández-Santamaría, 
• Isabel M. Jiménez-Sánchez, 
• Adriana Ariza, 
• Esther Barrionuevo, 
• Teresa Posadas, 
• María Salas, 
• Tahía Diana Fernández, 
• María José Torres & 
• María Isabel Montañez 

Clinical and Translational Allergy volume 10, Article number: 57 (2020) 

• details

Abstract

Background

Analysis of cross-reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam most often involved in immediate hypersensitivity reactions (IHRs), and cefadroxil (CX) the most likely cephalosporin to cross-react with AX, since they share the same R1 side chain, unlike cefuroxime (CO), with a structurally different R1. We aimed to analyse cross-reactivity with CX and CO in patients with confirmed IHRs to AX, including sIgE recognition to AX, CX, CO, and novel synthetic determinants of CX.

World Allergy Organization Journal Volume 13, Issue 11 , November 2020

Alert: World Allergy Organization Journal New Articles available on ScienceDirect

World Allergy Organization Journal Volume 13, Issue 11 , November 2020

The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study Article Number 100475 Marcus Maurer, Karsten Weller, Markus Magerl, Rasmus Robin Maurer, Emanuel Vanegas, Miguel Felix, Annia Cherrez, Valeria L. Mata, Alicja Kasperska-Zajac, Agnieszka Sikora, Daria Fomina, Elena Kovalkova, Kiran Godse, Nimmagadda Dheeraj Rao, Maryam Khoshkhui, Sahar Rastgoo, Roberta Fachini Jardim Criado, Mohamed Abuzakouk, Deepa Grandon, Martijn van Doorn

A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia Article Number 100477 Yu Ting Ng, Fook Tim Chew

Predominant patterns of β-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins

• Research
• Open Access
• 
  

Allergy, Asthma & Clinical Immunology

• Philipp Schrüfer, 
• Knut Brockow, 
• Johanna Stoevesandt & 
• Axel Trautmann 

Allergy, Asthma & Clinical Immunology volume 16, Article number: 102 (2020) 

Abstract

Background

Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsistent. We aimed to determine patterns of β-latam allergy, i.e. the association of a clinical reaction type with a specific β-lactam antibiotic.

Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management

• Case Report
• Open Access

Clinical and Molecular Allergy

• Stefania Magistà, 
• Marcello Albanesi, 
• Nada Chaoul, 
• Danilo Di Bona, 
• Elisabetta Di Leo, 
• Eustachio Nettis, 
• Maria Filomena Caiaffa & 
• Luigi Macchia 

Clinical and Molecular Allergy volume 18, Article number: 21 (2020) 

• details

Abstract

Background

Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, such as the measles, mumps, and rubella (MMR) vaccine, is regarded (erroneously) as potentially dangerous or even anaphylactogenic, by many. An issue perceived as particularly conflicting also by Health Professionals.

Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology

• Allergy, Asthma & Clinical ImmunologyReview
• Open Access

• Samira Jeimy, 
• Moshe Ben-Shoshan, 
• Elissa M. Abrams, 
• Anne K. Ellis, 
• Lori Connors & 
• Tiffany Wong 

volume Allergy, Asthma & Clinical Immunology 16, Article number: 95 (2020) 

• details

Abstract

The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public health. This article provides an overview of beta-lactam allergy, implications of erroneous beta-lactam allergy labels and the impact that can be provided by structured allergy assessment. We provide recommendations on how to stratify risk of beta-lactam allergy, beta lactam challenge protocols as well as management of patients at high risk of beta-lactam allergy.

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A single centre retrospective study of systemic reactions to subcutaneous immunotherapy

• Research
• Open Access

Allergy, Asthma & Clinical Immunology

• Kara Robertson, 
• Nazanin Montazeri, 
• Urvashi Shelke, 
• Samira Jeimy & 
• Harold Kim 

Allergy, Asthma & Clinical Immunology volume 16, Article number: 93 (2020) 

Abstract

Background

Subcutaneous immunotherapy (SCIT) is the standard approach for treating patients with sensitizations to aeroallergens. However, immunotherapy can trigger severe systemic reactions if delivered inappropriately or to high risk patients. We sought to characterize and quantify SCIT systemic reactions requiring epinephrine administration during a 6-year period in a Canadian setting following the recommendations for components and dosages published in the 2010 Canadian Society of Allergy and Clinical Immunology (CSACI) Immunotherapy Manual.