Abstract
Background
To explore the relationship between peripheral lymphocyte counts (PLCs) and the mortality risk of coronavirus disease 2019 (COVID-19), as well as the potential of PLC for predicting COVID-19 hospitalized patients death.
February 12, 2021
February 2, 2021
Long-term outcomes of 0.1% tacrolimus eye drops in eyes with severe allergic conjunctival diseases
- Research
- Open Access
Allergy, Asthma & Clinical Immunology 17, Article number: 11 (2021)
Background
Because atopic dermatitis does not heal completely, associated severe atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) often require long-term treatment. This study aims to evaluate the long-term outcomes of using 0.1% tacrolimus eye drops to treat these severe allergic conjunctival diseases.
Methods
Two-hundred-and-seventy eyes of 135 patients diagnosed with AKC or VKC from April 2004 to April 2014 were screened retrospectively. Patient demographics and objective signs were extracted from the electronic medical records.
January 16, 2021
Successful sublingual immunotherapy for severe egg allergy in children: a case report
Case report Open Access
Background
Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy. However, safety issues remain concerning severe adverse events requiring epinephrine injection. Hence, establishing a safer method to treat egg allergy would be beneficial. We report here two children with egg allergy who were safely treated with sublingual immunotherapy (SLIT) before transitioning to OIT.
January 15, 2021
Utility of basophil activation test for predicting the outcome of wheezing in children: a pilot study
- Research
- Open Access
Abstract
Background
No reliable biological marker for the diagnosis of asthma in younger children is currently available. In this study, we analyzed the differences in basophil activation test (BAT) results among children with recurrent wheezing episodes who had different asthma outcomes.
Results
 |
| Flow cytometry analysis of CD63-based BAT. |
December 16, 2020
Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils
- Research
- Open Access
Clinical and Translational Allergy
Clinical and Translational Allergy 10, Article number: 63 (2020)
Background
The role of chemokines in anaphylaxis is unclear.
Methods
We prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the absolute number of circulating basophils, monocytes, lymphocytes, and PMNs, and whole blood FCER1A, CPA3 and HDC gene expression at two time points: during the anaphylactic episode and in convalescent samples collected approximately 3 months later. We then investigated the in vitro chemotactic activity of chemokines induced during anaphylaxis for the in vitro migration of the corresponding cells.
December 15, 2020
The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a common progressive disorder of the respiratory system which is currently the third leading cause of death worldwide. Exhaled breath analysis is a non-invasive method to study lung diseases, and electronic noses have been extensively used in breath research.
December 9, 2020
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
December 7, 2020
First pediatric electronic algorithm to stratify risk of penicillin allergy
- Letter to the editor
- Open Access
Allergy, Asthma & Clinical Immunology
Allergy, Asthma & Clinical Immunology 16, Article number: 103 (2020)
Abstract
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