Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks

ORIGINAL ARTICLE

Open Access

Sarah E. Ashley, Anya C. Jones, Denise Anderson, Patrick G. Holt, Anthony Bosco, Mimi L. K. Tang

Allergy. 2022 May 25. doi: 10.1111/all.15324. Epub ahead of print. 

Abstract

Background

The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes.

Efficacy and Safety of Fluticasone Furoate and Oxymetazoline Nasal Spray: A Novel First Fixed Dose Combination for the Management of Allergic Rhinitis with Nasal Congestion

J Asthma Allergy. 2022; 15: 783–792.

R S Kumar, 1 Manish Kumar Jain, 2 Jitendra Singh Kushwaha, 3 Santosh Patil, 4 Vasanti Patil, 5 Soumya Ghatak, 6 Jayesh Sanmukhani, 7 and Ravindra Mittal 7

Abstract

Objective

To compare the efficacy and safety of a fixed dose combination of Fluticasone Furoate and Oxymetazoline Hydrochloride Nasal Spray 27.5/50 mcg (FDC) with Fluticasone Furoate Nasal Spray 27.5 mcg (Fluticasone) in the management of allergic rhinitis.

Patients and Methods

A prospective, randomized, double-blind, two-arm, active-controlled, parallel, multicenter, comparative clinical study was conducted in patients with allergic rhinitis aged 18 years and above having moderate-to-severe nasal congestion.

Adverse events for biologics in patients with CRSwNP: A meta-analysis

LETTER

Open Access

Yang Shen,Xia Ke,Suling Hong,Yucheng Yang

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common and complex inflammatory disorder in the upper airway. Type 2 inflammation affects the severity of CRSwNP and recurrence of polyps, determining the pharmacotherapy and extent of surgery, also associated with asthma comorbidity.1 Over the past decade, biologics targeting the biomarkers of type 2 immune reaction ---- IL-4, IL-5, and IgE, have been applied to CRSwNP in phase 2 or 3 clinical trials and emerged as an effective treatment option.

Intranasal budesonide for rhinitis during a high airborne pollution period: a randomized controlled trial

• Research
• Open Access
• 
  

• Yuan Zhang, 
• Chunguang Shan, 
• Weiwei Liu, 
• Yaozhong Han, 
• Guanggang Shi, 
• Yongjian Ma, 
• Kerstin Wagner, 
• Xiaoyan Tian, 
• Lili Zhang, 
• Allan Joseph Larona, 
• Steven Sacavage, 
• Kathleen Franklin, 
• Chengshuo Wang & 
• Luo Zhang 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 56 (2022) 

• details

Abstract

Background

Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis.

Objective

To assess the effectiveness of intranasal budesonide in adults with self-reported rhinitis symptoms triggered/worsened by airborne pollution.

Podotimod in pediatric recurrent respiratory tract infections: a cost-utility analysis

• Research
• Open Access
• 
  

• Jefferson Antonio Buendía, 
• Diana Guerrero Patiño & 
• Erika Fernanda Lindarte 

BMC Pulmonary Medicine volume 22, Article number: 244 (2022) 

• details

Abstract

Introduction

Despite the growing evidence on efficacy, few economic evaluations have evaluated the cost-utility of Pidotimod (PDT) supplementation to decrease the probability of recurrent respiratory tract infections in children. This study aimed to determine the cost-utility of PDT to reduce the incidence rate of recurrent respiratory tract infections in children.

Methods

A decision tree model was used to estimate the cost and quality-adjusted life-years (QALYs) of PDT in a patient aged 1–6 with a history of recurrent respiratory tract infections.

Systematic review of effectiveness and quality assessment of patient education materials and decision aids for breathlessness

• Research
• Open Access
• BMC Pulmonary Medicine

• Anthony Paulo Sunjaya, 
• Lexia Bao, 
• Allison Martin, 
• Gian Luca DiTanna & 
• Christine R. Jenkins 

BMC Pulmonary Medicine volume 22, Article number: 237 (2022) 

• details

Abstract

Background

Around 10% of adults suffer from clinically significant breathlessness. High quality and actionable patient education materials (PEMs) and patient decision aids (PDAs) have an important role for shared decision making and patient self-management.

Objective

To systematically assess the effectiveness of patient education materials (PEMs) and patient decision aids (PDAs) on clinical outcomes. Secondly, to assess the quality of PEMs and PDAs for breathlessness that are accessible online.

Methods

A systematic review of PEM or PDA intervention for breathlessness published between 1 January 2010 and November 2020 was conducted. An environmental scan and quality assessment of publicly available PEMs and PDAs was also conducted.

KIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation

• Research
• Open Access
• 
  

Zhengxia Wang, 

Jingjing Wu, 

Jingxian Jiang, 

Qiyun Ma, 

Meijuan Song, 

Tingting Xu, 

Yanan Liu, 

Zhongqi Chen, 

Yanmin Bao, 

Mao Huang, 

Mingshun Zhang & 

Ningfei Ji 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 55 (2022) 

• details

Abstract

Background

The microtubule-dependent molecular motor protein Kinesin Family Member 2A (KIF2A) is down-regulated in asthmatic human airway epithelium. However, little is known about the roles of KIF2A as well as the possible underlying mechanisms in asthma.

Methods

House dust mite (HDM) extract was administered to establish a murine model of asthma. The expression of KIF2A, IL-33 and the autophagy pathways were detected.

Artificial intelligence processing electronic health records to identify commonalities and comorbidities cluster at Immuno Center Humanitas

Clin Transl Allergy. 2022 Jun; 12(6): e12144.

Pierandrea Morandini, 1 Maria Elena Laino, 1 Giovanni Paoletti, 2 , 3 Alessandro Carlucci, 1 Tobia Tommasini, 1 Giovanni Angelotti, 1 Jack Pepys, 2 Giorgio Walter Canonica, 2 , 3 Enrico Heffler, 2 , 3 Victor Savevski, 1 and Francesca Puggioni 2 , 3

Abstract

Background 

Comorbidities are common in chronic inflammatory conditions, requiring multidisciplinary treatment approach. Understanding the link between a single disease and its comorbidities is important for appropriate treatment and management. We evaluate the ability of an NLP‐based process for knowledge discovery to detect information about pathologies, patients' phenotype, doctors' prescriptions and commonalities in electronic medical records, by extracting information from free narrative text written by clinicians during medical visits, resulting in the extraction of valuable information and enriching real world evidence data from a multidisciplinary setting.