Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Daniil Lisik,Athina Ioannidou,Giulia Spolidoro,Mohamed Ali,Sungkutu Nyassi,Yohanes Amera,Graciela Rovner,Ekaterina Khaleva,Carina Venter,Ronald van Ree,Margitta Worm,Berber Vlieg-Boerstra,Aziz Sheikh,Antonella Muraro,Graham Roberts,Bright I. Nwaru

https://doi.org/10.1002/clt2.12175

Abstract

Background

Recent reports indicate that the prevalence of food allergy is increasing, but accurate estimates remain a challenge due to cross-reactivity and limited use of precise diagnostic methods. Molecular allergy diagnostics, in which sensitization to individual molecular allergens is measured, is emerging as a promising tool for evaluation of sensitization profiles. In this systematic review, we summarized estimates of prevalence of sensitization to molecular food allergens in the general population in Europe.

Methods

Following a protocol prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO; reference CRD42021266657), we searched seven databases with no restrictions on publication date or language. Two reviewers independently screened the literature, extracted data, and appraised the risk of bias in the included studies. The findings were synthesized narratively.

Autoimmune progesterone dermatitis: a retrospective case series

Int J Womens Dermatol. 2022 Oct; 8(3): e009.

doi: 10.1097/JW9.0000000000000009

\

Nessa Aghazadeh,a Nicholas A. Berry,b Rochelle R. Torgerson,a,c Miguel A. Park,d,e and Dawn Marie R. Davisa,d,*

Background:

Patient with APD presenting with diffuse urticaria.

Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity disorder characterized by recurring dermatologic manifestations during the luteal phase of the menstrual cycle in women. Well-defined clinical and diagnostic criteria, outcomes measurements, and standard treatments are lacking.

Methods:

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease

• Research
• Open Access
• 
  

• Rebecca Bignold, 
• Bushra Shammout, 
• Jessica E. Rowley, 
• Mariaelena Repici, 
• John Simms & 
• Jill R. Johnson 

Respiratory Research 

volume23, Article number: 183 (2022) 

• details

Abstract

Background

Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequent loss of function. In the context of chronic allergic inflammation, pericytes have been shown to uncouple from the pulmonary microvasculature, migrate to areas of inflammation, and significantly contribute to airway wall remodeling and lung dysfunction. This study aimed to elucidate the mechanism by which pulmonary pericytes accumulate in the airway wall in a model of chronic allergic airway inflammation.

Cough hypersensitivity and chronic cough

Kian Fan Chung, 

Lorcan McGarvey, 

Woo-Jung Song, 

Anne B. Chang, 

Kefang Lai, 

Brendan J. Canning, 

Surinder S. Birring, 

Jaclyn A. Smith & 

Stuart B. Mazzone 

Nature Reviews Disease Primers volume 8, Article number: 45 (2022)

Abstract

Chronic cough is globally prevalent across all age groups. This disorder is challenging to treat because many pulmonary and extrapulmonary conditions can present with chronic cough, and cough can also be present without any identifiable underlying cause or be refractory to therapies that improve associated conditions. Most patients with chronic cough have cough hypersensitivity, which is characterized by increased neural responsivity to a range of stimuli that affect the airways and lungs, and other tissues innervated by common nerve supplies. Cough hypersensitivity presents as excessive coughing often in response to relatively innocuous stimuli, causing significant psychophysical morbidity and affecting patients’ quality of life. 

Effectiveness and safety of allergen immunotherapy in patients with allergic rhinitis complicated by rheumatic autoimmune diseases: a case series study

• Research
• Open Access
• 
  

• Kazuki Fujioka, 
• Akiko Kasahara, 
• Takashi Kida, 
• Wataru Fujii, 
• Takahiro Seno, 
• Makoto Wada, 
• Masataka Kohno & 
• Yutaka Kawahito 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 63 (2022) 

• details

Abstract

Background

Allergen immunotherapy (AIT) is the only treatment that has modified the natural history of allergic diseases. However, since its overall effect on the immune system has not been elucidated, AIT is either absolutely or relatively contraindicated in patients with rheumatic autoimmune diseases (RADs). Therefore, there have been no long-term observations of patients with RADs receiving AIT; thus, the effectiveness and safety of AIT in these patients remain unclear.

Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors

Int J Mol Sci. 2022 Jun; 23(12): 6579.

doi: 10.3390/ijms23126579

Takemichi Fukasawa,1 Asako Yoshizaki-Ogawa,1 Atsushi Enomoto,2 Kiyoshi Miyagawa,2 Shinichi Sato,1 and Ayumi Yoshizaki1,*

Sara Jane Ward, Academic Editor and Saadet Inan, Academic Editors

Abstract

Itching can decrease quality of life and exacerbate skin symptoms due to scratching. Itching not only contributes to disease progression but also triggers complications such as skin infections and eye symptoms. Therefore, controlling itching is very important in therapeutic management.

A novel pathogenetic factor of laryngeal attack in hereditary angioedema? Involvement of protease activated receptor 1

• Research
• Open Access
• 
  

• Henriette Farkas, 
• Csilla Máj, 
• István Kenessey, 
• Anna Sebestyén, 
• Ildikó Krencz, 
• Judit Pápay & 
• László Cervenak 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 60 (2022) 

• details

Abstract

Background

Hereditary angioedema (HAE) is a rare, life-threatening disease. The knowledge about the molecular pathogenesis of HAE has derived mainly from investigating blood samples. However, limited data are available on the role of the molecular mechanisms in the affected tissues during HAE attack.

Objective

The aim of our study was to explore the histological changes occurring in HAE attacks.

Methods

Post mortem macro-, microscopic and immunohistological assessment of upper airway tissues of a patient with HAE due to C1 inhibitor deficiency (C1-INH-HAE) type 2 who died from laryngeal HAE attack was compared with a non-HAE patient who died from other condition without any signs of angioedema.

Nasal mucosal reactivity assessment via a double-blind placebo-controlled food challenge with cow’s milk allergens

• Case report
• Open Access
• 
  

• Edyta Krzych-Fałta, 
• Oksana Wojas, 
• Piotr Samel-Kowalik, 
• Adam J. Sybilski & 
• Bolesław Samoliński 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 59 (2022) 

• details

Abstract

Background

Allergies, including food allergies, are a considerable clinical and public-health problem. The introduced preventive measures and differential diagnostics, including oral food challenges, are the gold standard for determining further treatment planning.

Case presentation

We present a case of an 18-year-old girl with a cow’s milk allergy who underwent an oral food challenge (double blind oral food challenge). Such a challenge may be confounded by inducing a response from other systems and organs, which provides theoretical grounds for the use of other methods of assessing the body’s response to food allergens (response demonstrated by the upper respiratory tract).