A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide

Xiaopei Liu, Xue Xiao, Dan Liu & Cong’e Tan. Annals ofMedicine, 54:1, 2078-2088, DOI: 10.1080/07853890.2022.2101689

Abstract

Objective

Eosinophilic esophagitis (EoE) is a chronic, local immune-mediated inflammatory oesophageal disease. Although Budesonide is recommended as one of the first-line drugs for EoE treatment, its efficacy is still controversial in multiple studies. Due to the continuous emergence of new and reliable research evidence in recent years, we updated the meta-analysis using RCT trial results to evaluate the efficacy and safety of budesonide.

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

J Asthma Allergy. 2022; 15: 957–970.

doi: 10.2147/JAA.S265660

Rita Vaz-Rodrigues, 1 Lorena Mazuecos, 1 and José de la Fuente 1 , 2

Abstract

The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms.

How Do Pollen Allergens Sensitize?

Svetlana V. Guryanova1,2, Ekaterina I. Finkina1, Daria N. Melnikova1, Ivan V. Bogdanov1, Barbara Bohle3 and Tatiana V. Ovchinnikova1,4*

• ¹Science-Educational Center, M. M. Shemyakin & Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, Moscow, Russia
• ²Medical Institute, Peoples’ Friendship University of Russia, The Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia
• ³Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
• ⁴Department of Biotechnology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

Plant pollen is one of the main sources of allergens causing allergic diseases such as allergic rhinitis and asthma. Several allergens in plant pollen are panallergens which are also present in other allergen sources. As a result, sensitized individuals may also experience food allergies. The mechanism of sensitization and development of allergic inflammation is a consequence of the interaction of allergens with a large number of molecular factors that often are acting in a complex with other compounds, for example low-molecular-mass ligands, which contribute to the induction a type 2-driven response of immune system.

A typical presentation of moxifloxacin-induced DRESS syndrome with pulmonary involvement: a case report and review of the literature

• Case report
• Open Access
• 
  

• Yinhong Zhang, 
• Xiaoyan Wang, 
• Yang Cheng, 
• Xiaofang Wang & 
• Yunjian Zhang 

BMC Pulmonary Medicine volume 22, Article number: 279 (2022) 

• details

Abstract

Background

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a kind of hypersensitivity drug reaction involving the skin and multiple internal organ systems. Moxifloxacin has rarely been reported to be a drug that is associated with DRESS syndrome. Lungs are less frequently involved in DRESS syndrome, but their involvements may herald more serious clinical processes. We present a rare typical case of moxifloxacin-induced DRESS syndrome with lungs involved. Valuable clinical data such as changes in the pulmonary imaging and pulmonary function tests was recorded. This case is important for the differential diagnosis of DRESS syndrome with lungs involved by providing clinical manifestations, CT imaging, pulmonary function tests, and biopsy pathological characteristics.

Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy

Allergy Asthma Immunol Res. 2022 Jul;14(4):424-438. English. https://doi.org/10.4168/aair.2022.14.4.424

Eun Gyul Kim, Ji Su Leem, Seung Min Baek, Hye Rin Kim, Kyung Won Kim, Mi Na Kim, and Myung Hyun Sohn

Abstract

Purpose The prevalence of food allergy, triggered by T-helper type 2 (Th2) cell-mediated inflammation, is increasing worldwide. Interleukin (IL)-18 plays an important role in inflammatory diseases by binding with the IL-18 receptor. IL-18/IL-18 receptor α (IL-18Rα) is a cofactor for immunoglobulin E (IgE) production and Th2 cell development. Studies have not investigated the association between the IL-18/IL-18Rα signaling pathway and food allergy. Here, we investigated the role of IL-18Rα in food allergy induction and development.

The Asthma Risk Is Increased in Children with Severe Allergic Rhinitis

 Ümmüsen Kaya Akca 1 , İbrahim Cemal Maslak 2 , Dilara Uygun 2 , Ayşen Bingöl 2 Author Affiliation(s)

Turk Arch Pediatr 2022; 57: 391-397

DOI: 10.5152/TurkArchPediatr.2022.21269

Objective: The aim of the study was to evaluate the allergic rhinitis severity, to identify risk fac- tors associated with asthma, and to determine the frequency of comorbid conditions in allergic rhinitis patients with positive skin prick test.

Materials and Methods: Clinical characteristics of pediatric patients with allergic rhinitis were investigated. The frequency of comorbidities and risk factors for asthma development were investigated.

Results: A total of 120 patients with a mean age of 13.05 ± 3.20 years were included in the study. Dermatophagoides pteronyssinus was the most common source of allergic sensitization (n = 78, 61.0%), whereas mild-persistent disease was the most common type of allergic rhini- tis severity (n = 44, 36.6%). Sensitization to Dermatophagoides farinea, Dermatophagoides pteronyssinus, and Alternaria was more common in patients with a moderate–severe course of allergic rhinitis than in the mild group (P = .006, P = .008, and P = .005, respectively). The most frequent comorbidity in children with allergic rhinitis was allergic conjunctivitis (71.7%).

Considerations in the management of hereditary angioedema due to C1-INH deficiency in women of childbearing age

• Review
• Open Access
• 
  

• Florence Ida Hsu, 
• William Lumry, 
• Marc Riedl & 
• Raffi Tachdjian 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 64 (2022) 

• details

Abstract

Hereditary angioedema (HAE) is a rare, autosomal disorder that manifests with unpredictable episodes of severe swelling of the skin and mucous membranes. These attacks can be highly disfiguring and range in severity from mild to—in cases of airway swelling—life-threatening. Fluctuations in female sex hormones—such as the changes that occur during puberty, menses, contraceptive use, pregnancy, and menopause—can all affect the frequency and severity of HAE attacks. Disease management decisions for women of childbearing age may be more complex and require additional considerations since they could develop complications related to contraception, pregnancy, labor, delivery, and lactation.

Diaphragm dysfunction as a potential determinant of dyspnea on exertion in patients 1 year after COVID-19-related ARDS

• Correspondence
• Open Access
• 
  

• Jens Spiesshoefer, 
• Janina Friedrich, 
• Binaya Regmi, 
• Jonathan Geppert, 
• Benedikt Jörn, 
• Alexander Kersten, 
• Alberto Giannoni, 
• Matthias Boentert, 
• Gernot Marx, 
• Nikolaus Marx, 
• Ayham Daher & 
• Michael Dreher 

• details

Respiratory Research volume 23, Article number: 187 (2022) 

volume

Abstract

Parameters measured during diaphragm ultrasound:
diaphragm excursion during tidal breathing
(A) and sniff maneuver (B);
and diaphragm thickness at functional residual capacity (FRC) (C)
and at total lung capacity (TLC) (D)

Some COVID-19 patients experience dyspnea without objective impairment of pulmonary or cardiac function. This study determined diaphragm function and its central voluntary activation as a potential correlate with exertional dyspnea after COVID-19 acute respiratory distress syndrome (ARDS) in ten patients and matched controls.