Chronic spontaneous urticaria guidelines: What is new?

Journal of Allergy and Clinical Immunology

Volume 150, Issue 6, December 2022, Pages 1249-1255

Review articles

Author links open overlay panel

https://doi.org/10.1016/j.jaci.2022.10.004

Urticaria is a heterogeneous inflammatory disorder that can be acute or chronic and is defined by the appearance of wheals, angioedema, or both. Very recently, the newest update and revision of the international European Academy of Allergy and Clinical Immunology/Global Allergy and Asthma European Network/European Dermatology Forum/Asia Pacific Association of Allergy Asthma Clinical Immunology guideline for the definition, classification, diagnosis, and management of urticaria was published. It aims to help primary care physicians and specialists in the management of their patients with urticaria.

OM-85 BV in pediatric recurrent respiratory tract infections: a cost-utility analysis

• Research Article
• Open Access
• 
  

• Jefferson Antonio Buendía, 
• Diana Guerrero Patiño & 
• Erika Fernanda Lindarte 

BMC Pulmonary Medicine volume 22, Article number: 465 (2022) 

• details

Abstract

Background

Despite the growing evidence on efficacy, little is known regarding the cost-utility of Vaxom/Imocur (OM-85 BV) supplementation to decrease the probability of recurrent respiratory tract infections in OM-85 BV to reduce the incidence of recurrent respiratory tract infections in children.

Methods

A decision tree model was used to estimate the cost and quality-adjusted life-years (QALYs) of OM-85 BV in a patient aged 1–6 with a history of recurrent respiratory tract infections.

Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app

Bousquet J, Sousa-Pinto B, Anto JM et al. Pulmonology. 2022 Nov 22:S2531-0437(22)00252-5. doi: 10.1016/j.pulmoe.2022.10.005. Epub ahead of print.

Free article

Abstract

Background: The self-reporting of asthma frequently leads to patient misidentification in epidemiological studies. Strategies combining the triangulation of data sources may help to improve the identification of people with asthma. We aimed to combine information from the self-reporting of asthma, medication use and symptoms to identify asthma patterns in the users of an mHealth app.

Methods: We studied MASK-air® users who reported their daily asthma symptoms (assessed by a 0-100 visual analogue scale - "VAS Asthma") at least three times (either in three different months or in any period). K-means cluster analysis methods were applied to identify asthma patterns based on: (i) whether the user self-reported asthma; (ii) whether the user reported asthma medication use and (iii) VAS asthma.

Treatment of Allergic Rhinitis and Asthma in Primary Care: Dispensations Do Not Align with Prescriptions

Belhassen M, Bérard M, Devouassoux G, Dalon F, Bousquet J, Van Ganse E.  J Asthma Allergy. 2022 Nov 25;15:1721-1729. doi: 10.2147/JAA.S376786. 

Free PMC article

Abstract

Background: Appropriate use of effective treatments is required for satisfactory control of allergic symptoms. Coherent medical care -regular prescribing by the same Health Care Professionals- is a preliminary need.

Objective: We investigated the numbers of distinct prescribers, the regularity of medical visits, and the agreement between prescriptions and associated dispensations in individual patients with perennial allergic rhinitis (PAR) and asthma.

Methods: In primary care electronic health records (EHRs), a cohort of patients with PAR and asthma was identified. Individual EHRs were linked to corresponding claims recording all dispensations. Prescribing patterns were analyzed for the major treatment classes, and the dispensations linked to individual prescriptions were retrieved to compute the proportions of days covered (PDCs) for asthma and PAR therapy.

Results: A total of 3654 patients were included, with 62% being female (mean age, 46.1 years). At inclusion, asthma control was not optimal in 51% of the patients and 48% had received oral corticosteroids. The mean interval between successive prescriptions varied between 93 (leukotriene receptor antagonists, LTRAs) and 103 (inhaled corticosteroids, ICS) days, and 97 (antihistamines, AHs) and 103 days (nasal corticosteroids, NCS). On average, individual prescriptions lead to 1.2, 1.5, 1.7 and 1.8 dispensations of ICS, ICS/Long-Acting Beta-Agonist (LABA) fixed-dose combinations, LABAs, and LTRAs, respectively, and to 1.3 and 1.6 dispensations of NCS and AHs, respectively. PDCs then varied between 37.8% for ICS and 58.6% for LTRAs, and between 39.7% for NCS and 50.4% for AHs.

Allergen immunotherapy for food allergy: Evidence and outlook

 Allergologie select, Volume 6 (2022) - 1st Issue (285 - 292)

Antonella Muraro, Angelo Tropeano, Mattia Giovannini

Abstract

Food allergy represents a significant health issue characterized by a sizeable epidemiological burden, involving up to 5% of adults and up to 8% of children in the Western world. The elimination diet of the trigger food is the cornerstone of food allergy management. However, novel treatment options are most wanted to provide alternative strategies for this potentially fatal medical condition.

LncRNAs ENST00000499459 and TCONS_00004989 enhance asthma progression in children with house dust mite-induced allergic asthma

• Research
• Open Access
• 
  

• Zhang Xude, 
• Feng Shaojie, 
• Guo Beibei, 
• Liu Jingjing, 
• Xu Donghua & 
• Liu Fengxia 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 101 (2022) 

• details

Abstract

Background

Long non-coding RNAs (lncRNAs) have been extensively reported to play critical roles in the pathogenesis of various disease, especially in cancer. However, little is known about the role of lncRNAs in the pathogenesis of pediatric allergic asthma.

Methods

High-throughput sequencing analysis was performed to identify differentially expressed mRNAs and lncRNAs in peripheral blood mononuclear cells (PBMCs) from 3 children with allergic asthma and 3 matched healthy controls.

Interventions for the long term prevention of hereditary angioedema attacks

Cochrane Database of Systematic Reviews Review - Intervention

• Nicole Beard
•  Michael Frese
•  Elena Smertina
•  Peter Mere
•  Constance Katelaris
 Kerry Mills

• 
  
  Cochrane Database of Systematic Reviews 2022, Issue 11. Art. No.: CD013403. 
• 
  

Abstract

Background

Hereditary angioedema (HAE) is a serious and potentially life‐threatening condition that causes acute attacks of swelling, pain and reduced quality of life. People with Type I HAE (approximately 80% of all HAE cases) have insufficient amounts of C1 esterase inhibitor (C1‐INH) protein; people with Type II HAE (approximately 20% of all cases) may have normal C1‐INH concentrations, but, due to genetic mutations, these do not function properly. A few people, predominantly females, experience HAE despite having normal C1‐INH levels and C1‐INH function (rare Type III HAE). Several new drugs have been developed to treat acute attacks and prevent recurrence of attacks. There is currently no systematic review and meta‐analysis that included all preventive medications for HAE.

Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs

Claude Mabilat, Marie-Françoise Gros, Alex Van Belkum, Jason A Trubiano, Kimberly G Blumenthal, Antonino Romano, Tristan T Timbrook

JAC-Antimicrobial Resistance, Volume 4, Issue 6, December 2022, dlac116

, https://doi.org/10.1093/jacamr/dlac116

Abstract

Penicillin allergy, the most frequently reported drug allergy, has been associated with suboptimal antibiotic therapy, increased antimicrobial resistance, increased rates of Clostridioides difficile colonization and infection, as well as extended hospital length of stay and increased cost. Although up to 10% of all patients may report penicillin allergy, most penicillin allergies are not confirmed. As such, most patients with a penicillin allergy can still safely use penicillin and related drugs following a more precise assessment. Herein, we review the current practices and unmet needs in penicillin allergy testing.