Hypersensitivity to permanent tattoos – literature summary and comprehensive review of patch tested tattoo patients 1997 – 2022

Steffen Schubert, Nicolas Kluger, Ines Schreiver

Hypersensitivity to permanent tattoos - literature summary and comprehensive review of patch tested tattoo patients 1997 - 2022. Contact Dermatitis. 2023 Feb 11. doi: 10.1111/cod.14291.  

Abstract

We outline constituents of tattoo and permanent make-up ink with regard to inflammatory tattoo reactions and population-based confounders. The comprehensive review of patch tested tattoo patients between 1997-2022 shows that tattoo allergy cannot be reliably diagnosed via patch testing with today's knowledge. Weak penetration and slow haptenization of pigments, unavailability of pigments as test allergens, and a lack of knowledge concerning relevant epitopes hamper the diagnosis of tattoo allergy. Patch testing p-phenylenediamine and disperse (textile) dyes is not able to close this gap.

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies

• Review
• Open Access
• 
  

• Rebecca J. Stinson, 
• Alyn H. Morice & 
• Laura R. Sadofsky 

Respiratory Research volume 24, Article number: 45 (2023) 

Abstract

Background

Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild and self-limiting, but due to the wide range of possible causative agents, including Rhinovirus (hRV), Adenovirus, Respiratory Syncytial Virus (RSV), Coronavirus and Influenza, there is no single and effective treatment. Over-the-counter (OTC) remedies, including traditional medicines and those containing plant derived substances, help to alleviate symptoms including inflammation, pain, fever and cough.

Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis

Altman MC, Kattan M, O'Connor GT, Murphy RC, et al.

Lancet Planet Health. 2023 Jan;7(1):e33-e44. doi: 10.1016/S2542-5196(22)00302-3.

Abstract

Background: Asthma prevalence and severity have markedly increased with urbanisation, and children in low-income urban centres have among the greatest asthma morbidity. Outdoor air pollution has been associated with adverse respiratory effects in children with asthma. However, the mechanisms by which air pollution exposure exacerbates asthma, and how these mechanisms compare with exacerbations induced by respiratory viruses, are poorly understood. We aimed to investigate the associations between regional air pollutant concentrations, respiratory illnesses, lung function, and upper airway transcriptional signatures in children with asthma, with particular focus on asthma exacerbations occurring in the absence of respiratory virus.

Risk factors for herpes zoster: should people with asthma or COPD be vaccinated?

• Review
• Open Access
• 
  

• Ekaterina Safonova, 
• Barbara P. Yawn, 
• Tobias Welte & 
• Chengbin Wang 

Respiratory Research volume 24, Article number: 35 (2023) 

Abstract

Without vaccination, an estimated 1 in 3 individuals will develop herpes zoster (HZ) in their lifetime. Increased risk of HZ is attributed to impaired cell-mediated immunity, as observed in age-related immunosenescence or in individuals immunocompromised due to disease or immunosuppressive treatments. Most vaccination guidelines recommend HZ vaccination in all adults ≥ 50 years of age, although Shingrix® was recently approved by the U.S. Food and Drug Administration for use in individuals aged ≥ 18 years who are or will be at increased risk of HZ due to immunodeficiency or immunosuppression caused by known disease or therapy, followed by approval by the European Medicines Agency for use in immunocompromised individuals aged ≥ 18 years.

Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases

	Zhang R. · Zhang L. · Li P. · Pang K. · Liu H. · Tian L.

Int Arch Allergy Immunol. 2023 Feb 1:1-21. doi: 10.1159/000528969. 

• ABSTRACT

As the first line of defense against risk factors, the nasal epithelial barrier maintains homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical, chemical, immune, and microbiological barriers. Together, these barriers form the nasal defense against irritations. Risk factors from both internal and external environments can disrupt them. External risk factors contain allergens containing proteases, bacteria, virus, particulate matter, diesel exhaust particles, and cigarette smoke. In the meantime, inflammatory cytokines also increase the load on the barrier.

Chronic recurrent wheals – If not chronic spontaneous urticaria, what else?

Allergol Select. 2023; 7: 8–16.

Hanna Bonnekoh,1,2 Karoline Krause,1,2 and Pavel Kolkhir1,2

Abstract

Chronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 – 4% of the general population. Urticarial vasculitis (UV) and autoinflammatory syndromes, i.e., cryopyrin-associated periodic syndromes (CAPS) and Schnitzler syndrome (SchS), can mimic CSU-like rash but represent rare disorders with systemic symptoms including fever, headache, conjunctivitis, and arthralgia. Clinical and laboratory features can point to the presence of any of these diseases in patients initially presenting with chronic urticarial rash. These include long-lasting wheals (> 24 hours), lesional burning, systemic symptoms, and/or increase in inflammatory markers (e.g., C-reactive protein, serum amyloid A, and/or S100A8/9).

Topical cyclosporine versus allergen specific immunotherapy in perennial allergic conjunctivitis

Dogan, C.U., Tuzer, C., Turker, I.C. et al. Int Ophthalmol (2022). https://doi.org/10.1007/s10792-022-02612-y

Abstract

Purpose

Symptom control in the long-term with less side effects is important in perennial allergic conjunctivitis, since would improve quality of life. This study aimed to assess the clinical efficacies of topical cyclosporin A and subcutaneous allergen immunotherapy (SCIT) in terms of sign control in perennial allergic conjunctivitis.

Methods

This retrospective study included 20 adult patients with perennial allergic conjunctivitis and confirmed sensitization to house dust mites with skin prick test.

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

• Research
• Open Access
• 
  

• Serhii Yuriev, 
• Victoria Rodinkova, 
• Vitalii Mokin, 
• Ilona Varchuk, 
• Olena Sharikadze, 
• Yuriy Marushko, 
• Bohdan Halushko & 
• Andrii Kurchenko 

Clinical and Molecular Allergy volume 21, Article number: 1 (2023) 

Abstract

Background

As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective.

Methods

The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used.