The holo beta-lactoglobulin lozenge reduces symptoms in cat allergy—Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge

Karl-Christian Bergmann, Jennifer Raab, Anke Graessel, Thomas Zwingers, Sylvia Becker, Sebastian Kugler, Torsten Zuberbier, Franziska Roth-Walter, Matthias F. Kramer, Erika Jensen-Jarolim

Clin Transl Allergy. 2023;e12274. https://doi.org/10.1002/clt2.12274

Abstract

Background

The allergists´ tool box in cat allergy management is limited. Clinical studies have shown that holo beta-lactoglobulin (holoBLG) can restore micronutritional deficits in atopic immune cells and alleviate allergic symptoms in a completely allergen-nonspecific manner. With this study, we aimed to provide proof of principle in cat allergy.

Methods

A novel challenge protocol for cat allergy in a standardized ECARF allergen exposure chamber (AEC) was developed. In an open pilot study (NCT05455749), patients with clinically relevant cat allergy were provoked with cat allergen for 120 min in the AEC before and after a 3-month intervention phase (holoBLG lozenge 2x daily). Nasal, conjunctival, bronchial, and pruritus symptoms were scored every 10 min– constituting the total symptom score (TSS). Peak nasal inspiratory flow (PNIF) was measured every 30 min. In addition, a titrated nasal provocation test (NPT) was performed before and after the intervention.

2-Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis. Part 2. Cross- and co-sensitization, other skin reactions to HEMA, position of HEMA among (meth)acrylates, sensitivity as screening agent, presence of HEMA in commercial products and practical information on patch test procedures

REVIEW

Free Access

Anton C. de Groot, Thomas Rustemeyer

 

Contact Dermatitis. 2023; 1-16. doi:10.1111/cod.14430

Abstract

This is the second part of a literature review of the clinical aspects of contact allergy to and allergic contact dermatitis from 2-hydroxyethyl methacrylate (HEMA). Topics include cross- and co-sensitization, atypical manifestations of contact allergy, frequency of positive patch tests to HEMA compared with other (meth)acrylates, sensitivity of HEMA as a screening agent, the presence of HEMA in commercial products, and practical information on patch testing procedures. Primary sensitization to methacrylates including HEMA may result in methacrylate and acrylate cross-sensitization.

2-Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis—Part 1. Introduction, epidemiology, case series and case reports

REVIEW

Free Access

Anton C. de Groot, Thomas Rustemeyer

Contact Dermatitis. 2023; 1-33. doi:10.1111/cod.14405

Abstract

2-Hydroxyethyl methacrylate (HEMA) has been increasingly recognised as a contact allergen and was added to the European baseline series in 2019. In this article (2 parts), the results of an extensive literature review of the clinical aspects of contact allergy/allergic contact dermatitis to HEMA are presented. In part 1, the epidemiology of HEMA contact allergy is discussed and detailed information on published case series and case reports presented. HEMA is an important cause of contact allergy/allergic contact dermatitis in North America and Europe with recent prevalences of >3% in the USA + Canada and 1.5%–3.7% in Europe. Currently, most cases are caused by nail cosmetics, both in consumers and professional nail stylists.

Managing Anaphylaxis – Epinephrine, Antihistamines, and Corticosteroids: Over 10 years of C-CARE Registry Data

Colli LD, Ali AA, Gabrielli S, Colli MD et al. Ann Allergy Asthma Immunol. 2023 Sep 7:S1081-1206(23)01214-0. doi: 10.1016/j.anai.2023.08.606.

Abstract

Background

Epinephrine is the first-line treatment for anaphylaxis but is often replaced with antihistamines or corticosteroids. Delayed epinephrine administration is a risk factor for fatal anaphylaxis. Convincing data on the role of antihistamines and corticosteroids in anaphylaxis management is sparse.

Objective

To establish the impact of prehospital treatment with epinephrine, antihistamines, and/or corticosteroids in anaphylaxis management.

Methods

Patients presenting with anaphylaxis were recruited prospectively and retrospectively in 10 Canadian and one Israeli emergency departments (ED) between April 2011 and August 2022, as part of the Cross-Canada Anaphylaxis Registry. Data on anaphylaxis cases were collected using a standardized form. 

Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis

• Article
• Open Access
• 
  

• Aiko Sekita, 
• Hiroshi Kawasaki, 
• Ayano Fukushima-Nomura, 
• Kiyoshi Yashiro, 
• Keiji Tanese, 
• Susumu Toshima, 
• Koichi Ashizaki, 
• Tomohiro Miyai, 
• Junshi Yazaki, 
• Atsuo Kobayashi, 
• Shinichi Namba, 
• Tatsuhiko Naito, 
• Qingbo S. Wang, 
• Eiryo Kawakami, 
• Jun Seita, 
• Osamu Ohara, 
• Kazuhiro Sakurada, 
• Yukinori Okada, 
• Masayuki Amagai & 
• Haruhiko Koseki

Nature Communications volume 14, Article number: 6133 (2023) 

• details

Abstract

Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the context of whole-body pathophysiology. Here we show, via integrated RNA-sequencing of skin tissue and peripheral blood mononuclear cell (PBMC) samples along with clinical data from 115 AD patients and 14 matched healthy controls, that specific clinical presentations associate with matching differential molecular signatures.

Breast feeding, obesity, and asthma association: clinical and molecular views

• Review
• Open Access

• Naghmeh Kian, 
• Alireza Bagheri, 
• Fardis Salmanpour, 
• Afsaneh Soltani, 
• Zahra Mohajer, 
• Noosha Samieefar, 
• Behzad Barekatain & 
• Roya Kelishadi 

Clinical and Molecular Allergy volume 21, Article number: 8 (2023)

• details

Abstract

Molecular pathways of leptin in obesity-related
asthma development

Asthma is a chronic condition that affects children worldwide. Accumulating number of studies reported that the prevalence of pediatric obesity and asthma might be altered through breastfeeding. It has been proposed that Leptin, which exists in human milk, is oppositely associated with weight increase in newborns. It may also influence peripheral immune system by promoting TH1 responses and suppressing TH2 cytokines.

Food-specific IgA levels in esophageal biopsies are not sufficiently high to predict food triggers in eosinophilic esophagitis

Abramson L, Smeekens JM, Kulis MD, Dellon ES. Immun Inflamm Dis. 2023 Sep;11(9):e1029. doi: 10.1002/iid3.1029. 

Abstract

Background

Eosinophilic esophagitis (EoE) is an immune-mediated disease, characterized by Th2-type inflammation linked to specific foods. No currently available allergy tests reliably identify food triggers in EoE, leading to empiric dietary elimination strategies. Recently, milk- and wheat-specific IgA in esophageal brushings were linked to clinical food triggers. In this study, we aimed to determine whether food-specific IgA from esophageal biopsies is associated with known food triggers.

Methods

A prior cohort of 21 patients (median age 39 years) with confirmed EoE underwent empirical elimination diets and subsequent reintroduction of foods to determine triggers.

A 14-year-old boy with severe erythema multiforme due to amoxicillin. Case report.

Kurihara M, Yamanishi S, Ozaki S, Pawankar R.  Asia Pac Allergy. 2023 Sep;13(3):135-138. doi: 10.5415/apallergy.0000000000000108.

Abstract

(A) Skin rash of ventral trunk. (B) Skin rash of lower extremities.

The most common cause of erythema multiforme (EM) in children is infectious diseases which account for approximately 90% of cases. Drug eruptions are another common cause. Here we are reporting about a male patient aged 14 years with lymphadenitis who developed severe diffuse erythema during the course of treatment with medications including several antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs). Based on the pathological findings of the skin biopsy, the skin rash was due to EM. Upon investigating the underlying cause of EM, viral antibody was positive for Coxsackie A6, lymphocyte transformation testing (LTT) was positive for one of the NSAIDs, and the patch test (PT) was positive for amoxicillin.