ABSTRACT
Background and Aims Ulcerative colitis (UC) and atopic dermatitis (AD) are immune-mediated inflammatory diseases with limited treatment options. They are known to be related which may explain higher risk of development of UC in patients with AD. The goal of this work is to review and analyse molecular mechanisms of UC in comparison to AD towards insights into UC complexity, potential comorbidities and novel therapies.
Abstract
Anaphylaxis prevention and management in the school setting is an important health and safety issue as the rates of food allergy in children continue to increase.
Objective
We describe the development and review of the Australian National Allergy Council best practice guidelines for anaphylaxis prevention and management in schools.
Methods
Developed in consultation with key stakeholders in health and education settings, the best practice guidelines incorporate 7 key recommendations for anaphylaxis prevention and management: an allergy aware approach; anaphylaxis management policy and plans; allergy documentation; emergency response; staff training; community and student education; and postincident management and incident reporting.
Abstract
Background: Allergen immunotherapy (AIT) is a well-established treatment for allergic diseases, particularly in patients with allergic rhinitis and asthma. In regions where patients are polysensitized, AIT can have broader immunomodulatory effects. This study investigates the impact of house dust mite AIT on IgE responses to both dust mites and non-target allergens, specifically Artemisia pollen, in polysensitized allergic rhinitis patients.
Abstract
Introduction
Methods
The panel of dermatologists conducted a systematic literature review and leveraged their clinical experience to develop generally accepted principles, consensus statements, and a treatment algorithm using an iterative consensus process.
Results
The panel collectively developed six generally accepted principles, 10 consensus statements, and a treatment algorithm. The guidance notes that assessment of disease severity should encompass both physician-rated measures and patient-reported outcomes. Disease education, lifestyle-based strategies (e.g., trigger avoidance), and supportive measures (e.g., moisturizers) can help reduce signs and symptoms of AD.
ABSTRACT
Background
Peanut oral immunotherapy (OIT) has shown effectiveness in achieving desensitization of children; however, evidence in adults is lacking.
Methods
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| Graphical Abstract |
This phase II trial evaluated peanut OIT in peanut-allergic adults using real-world peanut products. A Simon's minimax two-stage design, incorporating a stop:go for futility, was employed.
Key Points
Question What is the effect of herpes zoster vaccination on the probability of receiving a new diagnosis of dementia?
Findings In this quasi-experimental study using electronic health record data from Australia, being eligible for herpes zoster vaccination based solely on date of birth significantly decreased the probability of receiving a new dementia diagnosis during 7.4 years by 1.8 percentage points.
Meaning By taking advantage of a quasi-experiment, this study provides evidence for a beneficial effect of herpes zoster vaccination for preventing or delaying dementia that is more likely to be causal than the associations reported in the existing correlational evidence.
Importance Recent evidence from a quasi-experiment in Wales showed that herpes zoster (HZ) vaccination appears to prevent or delay dementia.
Abstract
Abstract
Background
We investigated whether maternal exposure to phthalate and bisphenol A (BPA) mixtures is associated with eczema in children, as most studies have only addressed single chemical exposures.
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| Graphical Abstract |
Nine phthalate metabolites and BPA were quantified in urine at gestational weeks 34-36 (n = 540) and total, inhalant, and food allergen-specific immunoglobulin (Ig)E levels (sx1, and fx5) were measured in serum from 4-year-old children of the LiNA cohort (n = 219). The association of prenatal exposure to phthalates and BPA, both single and mixed, with eczema and IgE was assessed in children stratified by atopy status.
