Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections A Phase 2 Randomized Clinical Trial

Lehr T, Meiser P, Selzer D, et al.  JAMA Intern Med. Published online September 02, 2025. doi:10.1001/jamainternmed.2025.4283

Key Points

Question  Is regular application of azelastine nasal spray associated with reduced risk of SARS-CoV-2 infections?

Findings  In this randomized placebo-controlled clinical trial that included 450 participants, the incidence of laboratory-confirmed SARS-CoV-2 infections was significantly lower with application of azelastine nasal spray compared with placebo treatment.

Meaning  The use of azelastine nasal spray may help to reduce the risk of SARS-CoV-2 infections.

Abstract

Importance  Limited pharmaceutical options exist for preexposure prophylaxis of COVID-19 beyond vaccination.

Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families

Ezzatpour S, Thakur K, Erzoah Ndede K et al.  Sci Adv. 2025 Aug 29;11(35):eady3554. doi: 10.1126/sciadv.ady3554. Epub 2025 Aug 27. 

Abstract

Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. 

Binding of SCRs to N-glycan microarrays

Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-CoV, EBOV, MARV, NiV, and HeV.

Early-life allergic sensitization and respiratory infection—Two hits on lung function?

Wadhwa V, Dharmage SC, Wurzel D, et al. Pediatr Allergy Immunol. 2025; 36:e70115. doi:10.1111/pai.70115

Abstract

Background

Allergic sensitization and respiratory infections commonly occur in childhood. Interplay between them in asthma development is known as the ‘two-hit’ hypothesis. There has been no previous investigation of this hypothesis on adult lung function.

Objective

In a birth cohort at high risk for allergic diseases, we investigated interactions between these two factors and lung function outcomes into adulthood.

Methods

Allergic sensitization was assessed at age 24 months by skin prick testing to aero and food allergens. Respiratory infection was defined as cough, rattle or wheeze measured by frequent questionnaires up to age 24 months. Regression models were utilized to identify interactions between these exposures and associations with lung function at ages 12, 18 and 25 years.

Results

Association between respiratory infection (increasing number of
months) and allergic sensitization with change in lung function
z-scores (post-bronchodilator)—sensitization status at 2 years.

At age 25 years, those sensitized at age 2 years(n = 118) demonstrated reductions in pre-bronchodilator FEV1 of 0.06(95% CI: −0.12, 0.00, z-score units, p = .055) for each additional month of respiratory infections.

RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons

Surie D, Self WH, Yuengling KA, et al. . JAMA. Published online August 30, 2025. doi:10.1001/jama.2025.15896

Key Points

Question  What is the effectiveness of 1 dose of respiratory syncytial virus (RSV) vaccine against RSV-associated hospitalization among adults aged 60 years or older during 2 RSV seasons and by time since vaccination?

Findings  In this multicenter, test-negative, case-control study of 6958 adults with RSV, estimated RSV vaccine effectiveness against RSV-associated hospitalization during 2 seasons was 58%. Vaccine effectiveness was 69% when vaccination occurred in the same season before illness onset and 48% when vaccination occurred in the prior season; these estimates were not statistically significantly different.

Validation and Acceptability of the Mobile App Version of the Control of Allergic Rhinitis and Asthma Test for Children (CARATKids): Cross-Sectional Study

Abreu da Mata D, Pais-Cunha I, Ferraz SC, da Rocha Couto D, Ferraz C, Silva S, Valente JC, Vieira-Marques P, A Fonseca J, Azevedo I, Jácome C.  JMIR Pediatr Parent. 2025 Jul 31;8:e73531. doi: 10.2196/73531. 

Abstract

Background: The electronic version of the Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) has the potential to enhance pediatric telemonitoring but has not yet been validated.

Objective: This study aimed to validate the electronic version of CARATKids against the paper-based version.

Methods: A cross-sectional study was conducted between April and December 2024 in a tertiary hospital in northern Portugal. Children with asthma or allergic rhinitis and their caregivers were recruited during pulmonology outpatient appointments.

The role of complement in long COVID pathogenesis

Bayarri-Olmos R, Bain W, Iwasaki A.  JCI Insight. 2025 Aug 22;10(16):e194314. doi: 10.1172/jci.insight.194314.

Abstract

Proposed drivers of complement activation in long COVID

Long COVID is a debilitating condition that can develop after a SARS-CoV-2 infection and is characterized by a wide range of chronic symptoms, including weakness, neurocognitive impairment, malaise, fatigue, and many others, that affect multiple organ systems. At least 10% of individuals with a previous infection may develop long COVID, which affects their ability to perform daily functions and work.

Distinct trajectories of childhood atopic dermatitis are associated with differences in long-term inflammatory and cardiometabolic disease risks

Florian Thaçi, Philip Curman, Katja Bieber, Henning Olbrich, Diamant Thaçi, Ralf J. Ludwig

medRxiv 2025.08.18.25333898; doi: https://doi.org/10.1101/2025.08.18.25333898

This article is a preprint and has not been certified by peer review. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

Abstract

Importance Atopic dermatitis (AD) is a common childhood inflammatory skin disease which occurs frequently in the early childhood and is later linked to type 2 diseases but also other systemic comorbidities. The role of different AD-disease trajectories on long-term health outcomes remains unclear, as prior studies have rarely conducted direct comparisons between distinct AD trajectories.

Objective To assess how different childhood AD trajectories - persistent, transient - or none, are associated with long-term risks of other type 2 inflammatory diseases (T2IDs), autoimmune diseases, and cardiometabolic disorders by performing all pairwise comparisons to identify trajectory-specific risk patterns.

Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product-Based Therapies

Fan, X., Z. Liu, W. Yang, et al. 2025. Phytotherapy Research 1–30. https://doi.org/10.1002/ptr.70056.

ABSTRACT

Graphical Abstract

Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden. Recent studies have shown that AD is characterized by complex interactions between multiple signaling pathways and targets, including allergies, inflammation, oxidative stress, apoptosis, and their interactions. This complex pathogenesis poses challenges for effective treatment but also contributes to the discovery of new therapeutic targets and the development of novel therapeutic drugs, which have important clinical significance.