Abstract
Background: Allergen immunotherapy (AIT) is a well-established treatment for allergic diseases, particularly in patients with allergic rhinitis and asthma. In regions where patients are polysensitized, AIT can have broader immunomodulatory effects. This study investigates the impact of house dust mite AIT on IgE responses to both dust mites and non-target allergens, specifically Artemisia pollen, in polysensitized allergic rhinitis patients.
Abstract
Introduction
Methods
The panel of dermatologists conducted a systematic literature review and leveraged their clinical experience to develop generally accepted principles, consensus statements, and a treatment algorithm using an iterative consensus process.
Results
The panel collectively developed six generally accepted principles, 10 consensus statements, and a treatment algorithm. The guidance notes that assessment of disease severity should encompass both physician-rated measures and patient-reported outcomes. Disease education, lifestyle-based strategies (e.g., trigger avoidance), and supportive measures (e.g., moisturizers) can help reduce signs and symptoms of AD.
ABSTRACT
Background
Peanut oral immunotherapy (OIT) has shown effectiveness in achieving desensitization of children; however, evidence in adults is lacking.
Methods
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| Graphical Abstract |
This phase II trial evaluated peanut OIT in peanut-allergic adults using real-world peanut products. A Simon's minimax two-stage design, incorporating a stop:go for futility, was employed.
Key Points
Question What is the effect of herpes zoster vaccination on the probability of receiving a new diagnosis of dementia?
Findings In this quasi-experimental study using electronic health record data from Australia, being eligible for herpes zoster vaccination based solely on date of birth significantly decreased the probability of receiving a new dementia diagnosis during 7.4 years by 1.8 percentage points.
Meaning By taking advantage of a quasi-experiment, this study provides evidence for a beneficial effect of herpes zoster vaccination for preventing or delaying dementia that is more likely to be causal than the associations reported in the existing correlational evidence.
Importance Recent evidence from a quasi-experiment in Wales showed that herpes zoster (HZ) vaccination appears to prevent or delay dementia.
Abstract
Abstract
Background
We investigated whether maternal exposure to phthalate and bisphenol A (BPA) mixtures is associated with eczema in children, as most studies have only addressed single chemical exposures.
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| Graphical Abstract |
Nine phthalate metabolites and BPA were quantified in urine at gestational weeks 34-36 (n = 540) and total, inhalant, and food allergen-specific immunoglobulin (Ig)E levels (sx1, and fx5) were measured in serum from 4-year-old children of the LiNA cohort (n = 219). The association of prenatal exposure to phthalates and BPA, both single and mixed, with eczema and IgE was assessed in children stratified by atopy status.
Abstract
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Interplay between AIT and biologics in modulating allergic inflammation. |
Objective: To analyze sensitization to Dermatophagoides pteronyssinus and to investigate the association between diagnostic findings and clinical severity in 218 allergic patients from 2 continents.
Methods: Mite-allergic patients were recruited by allergology departments in Latin America (n=88: Colombia, Costa Rica, and Guatemala) and Spain (n=130). All patients had allergic rhinitis with or without asthma and positive skin prick test results to D pteronyssinus. Specific IgE levels to D pteronyssinus, Dermatophagoides farinae, Der p 1, Der p 2, and Der p 23 were quantified using ImmunoCAP (Thermo Fisher Scientific). The allergenic profile was also determined by Western blotting. A comparative statistical analysis was performed using GraphPad software.
