Li M.
September 12, 2014
Japanese guideline for occupational allergic diseases 2014
REVIEW ARTICLE
Kunio Dobashi, Kazuo Akiyama, Atsushi Usami, Hiroo Yokozeki, Zenro Ikezawa, Naomi Tsurikisawa, Yoichi Nakamura, Kazuhiro Sato, Jiro Okumura, on behalf of Committee for Japanese Guideline for Diagnosis and Management of Occupational Allergic Diseases and Japanese Society of Allergology [About this authors]
September 11, 2014
Placebo Controlled Randomised Trial of Medical Therapy in Otitis Media with Effusion
Glenis Kathleen Scadding* , Allergy & Rhinology , University College London , United Kingdom
Yvonne Colette Darby , Allergy & Rhinology , Royal National TNE Hospital
Anna Jansz , Allergy & Rhinology , RNTNE Hospital, London
David Richards , Respiratory , *Glaxo Smith Kline, Stevenage.
Helen Tate , Statistics , MSD Hertford Rd, Hoddesdon, EN11 9BU
Simon Gane , ENT Surgery , University College London
Abstract
Objective
To explore rhinitis treatment, with and without autoinflation of the middle ear, as therapy for otitis media with effusion
To explore rhinitis treatment, with and without autoinflation of the middle ear, as therapy for otitis media with effusion
September 10, 2014
Severe Asthma Phenotyping: The Applicability of Current Proposols in Daily Practice
Research Article
Volume 1 Issue 1 - 2014
1Department of Internal Medicine, Division of Immunology and Allergic Diseases, Recep Tayyip Erdogan University School of Medicine, Turkey
2Divison of Immunology and Allergic Diseases, Ataturk Chest Disease and Thoracic Surgery Trainig and Research Hospital, Turkey
3Department of Respiratory Medicine, Izzet Baysal University School of Medicine, Turkey
2Divison of Immunology and Allergic Diseases, Ataturk Chest Disease and Thoracic Surgery Trainig and Research Hospital, Turkey
3Department of Respiratory Medicine, Izzet Baysal University School of Medicine, Turkey
Received: August 12, 2014 | Published: August 21, 2014
*Corresponding author: Adile Berna Dursun, Department of Internal Medicine, Division of Immunology and Allergic Diseases, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey, Tel: 905325874868; Email: @
Citation: Dursun AB, Erkekol FO, Kurt OK (2014) Severe Asthma Phenotyping: The Applicability of Current Proposols in Daily Practice. J Lung Pulm Respir Res 1(1): 00003. http://dx.doi.org/10.15406/jlprr.2014.01.00003
Abstract
Background: Severe asthma (SA) is also need to be phenotyping. We aimed to demonstrate the applicability of current definition and classification proposals in daily practice.
Methods: SA patients, according to WHO definition of treatment resistant SA, were enrolled from the allergy clinic. The SARP algorith define and WHO proposal were applied to the subjects independently by asthma experts. Demographic and clinical characteristics of the subjects were used for the comparison.
Results: Ninety-five (F/M: 68/27) patients with a mean age of 45.97± 9.44 years (range25-71) were enrolled. The patients were grouped as controlled treatment-resistant SA (56%) and uncontrolled treatment resistant SA group (44%). There was no statistically significant difference between the groups but aspirin hypersensitivity. 49% of patients was classified as exacerbators, 26% as fixed airway obstruction group and 23% as undefined (other 2%). Age and mold sensitivity was higher; FEV1/FVC and FEF25-75 were lower in exacerbation-prone SA. More than half of the patients were define clustered at 4 and 5 according to SARP proposol. Patients with fixed obstruction were only in the clusters 4 and 5.
Conclusion: Current phenotyping proposols failed to cover all SA patients. Thus, there is still need further investigations in order to explore validity and applicability of the phenotyping of SA.
Methods: SA patients, according to WHO definition of treatment resistant SA, were enrolled from the allergy clinic. The SARP algorith define and WHO proposal were applied to the subjects independently by asthma experts. Demographic and clinical characteristics of the subjects were used for the comparison.
Results: Ninety-five (F/M: 68/27) patients with a mean age of 45.97± 9.44 years (range25-71) were enrolled. The patients were grouped as controlled treatment-resistant SA (56%) and uncontrolled treatment resistant SA group (44%). There was no statistically significant difference between the groups but aspirin hypersensitivity. 49% of patients was classified as exacerbators, 26% as fixed airway obstruction group and 23% as undefined (other 2%). Age and mold sensitivity was higher; FEV1/FVC and FEF25-75 were lower in exacerbation-prone SA. More than half of the patients were define clustered at 4 and 5 according to SARP proposol. Patients with fixed obstruction were only in the clusters 4 and 5.
Conclusion: Current phenotyping proposols failed to cover all SA patients. Thus, there is still need further investigations in order to explore validity and applicability of the phenotyping of SA.
Keywords: Adult asthma; Severe asthma; Phenotype; Cluster analysis; Refractory asthma; Difficult-to-treat asthma
September 9, 2014
September 8, 2014
September 6, 2014
Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis
Mediators of Inflammation
Volume 2014 (2014), Article ID 746846, 13 pages
http://dx.doi.org/10.1155/2014/746846
Research Article
1Department of Otolaryngology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical College, No. 9 Jinsui Road, Guangzhou 510623, China
2Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China
2Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China
Received 9 December 2013; Revised 4 July 2014; Accepted 14 July 2014; Published 11 August 2014
Academic Editor: Arkadiusz Orzechowski
Copyright © 2014 Wenlong Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background. Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses, especially its isoform IL-37b. Objective. This study was undertaken to evaluate the expression and regulation of IL-37b in children with allergic rhinitis (AR).Methods. Forty children with AR and twenty-five normal controls were included. The relationship between IL-37b and Th1/2 cytokines production in serum and nasal lavage was examined by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-37b. Intranasal mometasone furoate was given in AR children and IL-37b change after one-month treatment was detected using ELISA. Results. We observed significantly decreased IL-37b expression levels in both serum and nasal lavage compared to controls. IL-37b was negatively correlated with Th2 cytokines. Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and this modulation was through mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathway. We also found that intranasal mometasone furoate therapy can promote nasal IL-37b expression.Conclusion. IL-37b may be involved in Th2 cytokine regulation in AR and its expression was related to the efficacy of intranasal steroid therapy.
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