Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance

PLoS Genet. 2015 Mar; 11(3): e1005076.

Published online 2015 Mar 10. doi:  10.1371/journal.pgen.1005076

PMCID: PMC4355615

Jorge Esparza-Gordillo,1,2 Anja Matanovic,1,2 Ingo Marenholz,1,2 Anja Bauerfeind,1 Klaus Rohde,1 Katja Nemat,3 Min-Ae Lee-Kirsch,3 Magnus Nordenskjöld,4 Marten C. G. Winge,4 Thomas Keil,5 Renate Krüger,6 Susanne Lau,6 Kirsten Beyer,6 Birgit Kalb,6 Bodo Niggemann,6 Norbert Hübner,1 Heather J. Cordell,7 Maria Bradley,4,8 and Young-Ae Lee1,2,*

Author information ► Article notes ► Copyright and License information ►

Abstract

Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects reflecting the maternal genome's influence on the child during prenatal development.

Effect of breastfeeding on lung function in asthmatic children

• Allergy and Asthma Proceedings
• Volume 36, Issue 2, pages 116-122

Hwan Soo Kim, M.D.1; Yoon Hee Kim, M.D.2; Min Jung Kim, M.D.2; Hee Seon Lee, M.D.2; Yoon Ki Han, M.D.2; Kyung Won Kim, M.D., Ph.D.2; Myung Hyun Sohn, M.D., Ph.D.2; Kyu-Earn Kim, M.D., Ph.D.2

From the ¹Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea, and ²Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

Address correspondence to Kyung Won Kim, M.D., Ph.D., Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail address: kwkim@yuhs.ac

ABSTRACT

Effect of breastfeeding on the protective effect on asthma has been studied extensively but remains controversial. Studies regarding the effect of breastfeeding on lung function have also been conflicting. The aim of this study was to determine the influence of breastfeeding on lung function in asthmatic children. We included 555 patients who visited Severance Children's Hospital Allergy Clinic with asthma.

A practical approach to vitamin and mineral supplementation in food allergic children

Research

Rosan Meyer^1*, Claire De Koker², Robert Dziubak¹, Ana-Kristina Skrapac², Heather Godwin¹, Kate Reeve¹, Adriana Chebar-Lozinsky¹ and Neil Shah¹³Clinical and Translational Allergy 2015, 5:11  doi:10.1186/s13601-015-0054-y

Abstract (provisional)

Background The management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management.

Chronic urticaria in adults: state-of-the-art in the new millennium

• An Bras Dermatol
• v.90(1); Jan-Feb 2015
• PMC4323701

An Bras Dermatol. 2015 Jan-Feb; 90(1): 74–89.

doi:  10.1590/abd1806-4841.20153509

Paulo Ricardo Criado,1 Roberta Facchini Jardim Criado,2 Celina Wakisaka Maruta,1 and Vitor Manoel Silva dos Reis1Author information ► Article notes ► Copyright and License information ►
Keywords: Angioedema, Biological factors, Colchicine, Cyclosporine, Dapsone, Immunosuppressive agents, Urticaria

Abstract

Chronic urticaria has been explored in several investigative aspects in the new millennium, either as to its pathogenesis, its stand as an autoimmune or auto-reactive disease, the correlation with HLA-linked genetic factors, especially with class II or its interrelation with the coagulation and fibrinolysis systems.

Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

Research

Christoffer V Nissen, Carsten Bindslev-Jensen and Charlotte G Mortz^*

Clinical and Translational Allergy 2015, 5:10  doi:10.1186/s13601-015-0052-0

Abstract (provisional)

Background Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA2LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system. 

Methods Patients with a clinical history of NSAID hypersensitivity referred to the Allergy Centre, Odense University Hospital between 2002 and 2011 and evaluated with oral provocation tests (OPTs) were included in the study. Medical records were retrospectively investigated with respect to the culprit NSAID(s), underlying diseases and symptoms at the primary reaction and during oral provocation tests (OPTs). Data was supplemented with a questionnaire. Classification according to EAACI guideline was based on these findings. 

Results In total 149 patients were included. Of those, 39 patients (26.2%) had a positive OPT. Twenty-nine patients were classified as cross-reactive responders and 9 patients as single NSAID responders after positive OPTs with the culprit NSAID, but not to acetylsalicylic acid. All single NSAID responders reacted to non-pyrazolone drugs. Only one patient could not be classified according to the EAACI/ENDA system. An overlap between respiratory and cutaneous symptoms was found in 15/39 (38%) of patients. 

Conclusions All but one of our patients could be classified according to the EAACI classification system. Overlaps between different classes may occur much more commonly than expected.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy

Case Reports in Immunology
Volume 2015 (2015), Article ID 816424, 5 pages
http://dx.doi.org/10.1155/2015/816424

Case Report

Teresa Urraro, Laura Gragnani, Alessia Piluso, Alessio Fabbrizzi, Monica Monti, Elisa Fognani, Barbara Boldrini, Jessica Ranieri, and Anna Linda Zignego

Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Lagro Brambilla 3, 50134 Florence, Italy

Received 26 September 2014; Revised 9 January 2015; Accepted 20 January 2015

Academic Editor: Lenin Pavón

Copyright © 2015 Teresa Urraro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mixed cryoglobulinemia (MC) is an autoimmune/B-cell lymphoproliferative disorder associated with Hepatitis C Virus (HCV) infection, manifesting as a systemic vasculitis.

Evaluation of the applicability of the Immuno-solid-phase allergen chip (ISAC) assay in atopic patients in Singapore

Research

Amelia Santosa^12*, Anand Kumar Andiappan³, Olaf Rotzschke³, Hung Chew Wong², Amanda Chang⁴, Mei Bigliardi-Qi⁵,De-Yun Wang⁶ and Paul Lorenz Bigliardi¹⁵

Clinical and Translational Allergy 2015, 5:9  doi:10.1186/s13601-015-0053-z

Background/Objective Molecular-based allergy diagnostics are gaining popularity in clinical practice. Our aim was to evaluate their role in the tropics, given the inherent genetic and environmental differences.

Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium

Research

Jie Xu, Gurpreet K Singhera and Delbert R Dorscheid^*

Respiratory Research 2015, 16:26  doi:10.1186/s12931-015-0177-7

Abstract (provisional)

Background Surfactant protein D (SP-D), a pattern recognition molecule, has been shown to play roles in host defense such as opsonisation, aggregation of pathogens, and modulation of the inflammatory response. In light of infection-induced exacerbations and damage to the airway epithelium from inflammation, these functions of SP-D make it relevant in the development and pathogenesis of asthma.