A blog that publishes updates and open access scientific papers about allergy, asthma and immunology. Editor: Juan Carlos Ivancevich, MD. Specialist in Allergy & Immunology
March 28, 2015
March 19, 2015
Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance
PLoS Genet. 2015 Mar; 11(3): e1005076.
Published online 2015 Mar 10. doi: 10.1371/journal.pgen.1005076
PMCID: PMC4355615
Jorge Esparza-Gordillo,1,2 Anja Matanovic,1,2 Ingo Marenholz,1,2 Anja Bauerfeind,1 Klaus Rohde,1 Katja Nemat,3 Min-Ae Lee-Kirsch,3 Magnus Nordenskjöld,4 Marten C. G. Winge,4 Thomas Keil,5 Renate Krüger,6 Susanne Lau,6 Kirsten Beyer,6 Birgit Kalb,6 Bodo Niggemann,6 Norbert Hübner,1 Heather J. Cordell,7 Maria Bradley,4,8 and Young-Ae Lee1,2,*
Abstract
Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects reflecting the maternal genome's influence on the child during prenatal development.
March 10, 2015
Effect of breastfeeding on lung function in asthmatic children
- Allergy and Asthma Proceedings
- Volume 36, Issue 2, pages 116-122
- Hwan Soo Kim, M.D.1; Yoon Hee Kim, M.D.2; Min Jung Kim, M.D.2; Hee Seon Lee, M.D.2; Yoon Ki Han, M.D.2; Kyung Won Kim, M.D., Ph.D.2; Myung Hyun Sohn, M.D., Ph.D.2; Kyu-Earn Kim, M.D., Ph.D.2
- From the 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea, and 2Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
Effect of breastfeeding on the protective effect on asthma has been studied extensively but remains controversial. Studies regarding the effect of breastfeeding on lung function have also been conflicting. The aim of this study was to determine the influence of breastfeeding on lung function in asthmatic children. We included 555 patients who visited Severance Children's Hospital Allergy Clinic with asthma.
A practical approach to vitamin and mineral supplementation in food allergic children
March 4, 2015
Chronic urticaria in adults: state-of-the-art in the new millennium
- An Bras Dermatol
- v.90(1); Jan-Feb 2015
- PMC4323701
An Bras Dermatol. 2015 Jan-Feb; 90(1): 74–89.
Paulo Ricardo Criado,1 Roberta Facchini Jardim Criado,2 Celina Wakisaka Maruta,1 and Vitor Manoel Silva dos Reis1Author information ► Article notes ► Copyright and License information ►
Keywords: Angioedema, Biological factors, Colchicine, Cyclosporine, Dapsone, Immunosuppressive agents, Urticaria
Abstract
Chronic urticaria has been explored in several investigative aspects in the new millennium, either as to its pathogenesis, its stand as an autoimmune or auto-reactive disease, the correlation with HLA-linked genetic factors, especially with class II or its interrelation with the coagulation and fibrinolysis systems.
Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines
Abstract (provisional)
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA2LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system.
Methods Patients with a clinical history of NSAID hypersensitivity referred to the Allergy Centre, Odense University Hospital between 2002 and 2011 and evaluated with oral provocation tests (OPTs) were included in the study. Medical records were retrospectively investigated with respect to the culprit NSAID(s), underlying diseases and symptoms at the primary reaction and during oral provocation tests (OPTs). Data was supplemented with a questionnaire. Classification according to EAACI guideline was based on these findings.
Results In total 149 patients were included. Of those, 39 patients (26.2%) had a positive OPT. Twenty-nine patients were classified as cross-reactive responders and 9 patients as single NSAID responders after positive OPTs with the culprit NSAID, but not to acetylsalicylic acid. All single NSAID responders reacted to non-pyrazolone drugs. Only one patient could not be classified according to the EAACI/ENDA system. An overlap between respiratory and cutaneous symptoms was found in 15/39 (38%) of patients.
Conclusions All but one of our patients could be classified according to the EAACI classification system. Overlaps between different classes may occur much more commonly than expected.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production. |
Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy
Case Reports in Immunology
Volume 2015 (2015), Article ID 816424, 5 pages
http://dx.doi.org/10.1155/2015/816424
Case Report
Teresa Urraro, Laura Gragnani, Alessia Piluso, Alessio Fabbrizzi, Monica Monti, Elisa Fognani, Barbara Boldrini, Jessica Ranieri, and Anna Linda Zignego
Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Lagro Brambilla 3, 50134 Florence, Italy
Received 26 September 2014; Revised 9 January 2015; Accepted 20 January 2015
Academic Editor: Lenin Pavón
Copyright © 2015 Teresa Urraro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Mixed cryoglobulinemia (MC) is an autoimmune/B-cell lymphoproliferative disorder associated with Hepatitis C Virus (HCV) infection, manifesting as a systemic vasculitis.
March 2, 2015
Evaluation of the applicability of the Immuno-solid-phase allergen chip (ISAC) assay in atopic patients in Singapore
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