CSACI position statement: systemic effect of inhaled corticosteroids on adrenal suppression in the management of pediatric asthma

Position article and guidelines

Karine Issa-El-Khoury¹, Harold Kim²³, Edmond S Chan⁴, Tim Vander Leek⁵ and Francisco Noya^1*

Allergy, Asthma & Clinical Immunology 2015, 11:9  doi:10.1186/s13223-015-0075-z

Abstract

Asthma is a chronic inflammatory disease of the airways that affects a growing number of children and adolescents. Inhaled corticosteroids (ICS) are the mainstay of treatment in persistent asthma, with a stepwise approach to increasing doses of ICS depending on asthma severity and control. ICS have known local and systemic side effects, of which adrenal suppression is still under-recognized.

Abstracts from the 2nd International Severe Asthma Forum (ISAF) -Athens, Greece 13-15 November 2014

Meeting abstracts

2nd International Severe Asthma Forum (ISAF)

Athens, Greece

13-15 November 2014

Publication charges for this supplement were funded by The European Academy of Allergy and Clinical Immunology (EAACI).

Conference website

Clinical and Translational Allergy publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 5 Supplement 2

Oral presentation    Th2-high asthma: a heterogeneous asthma population? Seys Sven, Hans Scheers, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter Goeminne, Paul Van den Brande, Jan Ceuppens, Lieven Dupont, Dominique BullensClinical and Translational Allergy 2015, 5(Suppl 2):O1 (23 March 2015) Full text | PDF

Oral presentation    Phenotyping asthma using an unsupervised prediction model based on blood granulocyte responsiveness Bart Hilvering, Susanne Vijverberg, Jeroen Jansen, Leo Houben, Rene Schweizer, Jan-Willem Lammers, Leo KoendermanClinical and Translational Allergy 2015, 5(Suppl 2):O2 (23 March 2015) Full text | PDF

World Allergy Week 2015 - Slide Set Presentation

World Allergy Week 2015: AIRWAY ALLERGIES The human and economic burden 

Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance

PLoS Genet. 2015 Mar; 11(3): e1005076.

Published online 2015 Mar 10. doi:  10.1371/journal.pgen.1005076

PMCID: PMC4355615

Jorge Esparza-Gordillo,1,2 Anja Matanovic,1,2 Ingo Marenholz,1,2 Anja Bauerfeind,1 Klaus Rohde,1 Katja Nemat,3 Min-Ae Lee-Kirsch,3 Magnus Nordenskjöld,4 Marten C. G. Winge,4 Thomas Keil,5 Renate Krüger,6 Susanne Lau,6 Kirsten Beyer,6 Birgit Kalb,6 Bodo Niggemann,6 Norbert Hübner,1 Heather J. Cordell,7 Maria Bradley,4,8 and Young-Ae Lee1,2,*

Author information ► Article notes ► Copyright and License information ►

Abstract

Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects reflecting the maternal genome's influence on the child during prenatal development.

Effect of breastfeeding on lung function in asthmatic children

• Allergy and Asthma Proceedings
• Volume 36, Issue 2, pages 116-122

Hwan Soo Kim, M.D.1; Yoon Hee Kim, M.D.2; Min Jung Kim, M.D.2; Hee Seon Lee, M.D.2; Yoon Ki Han, M.D.2; Kyung Won Kim, M.D., Ph.D.2; Myung Hyun Sohn, M.D., Ph.D.2; Kyu-Earn Kim, M.D., Ph.D.2

From the ¹Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea, and ²Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

Address correspondence to Kyung Won Kim, M.D., Ph.D., Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail address: kwkim@yuhs.ac

ABSTRACT

Effect of breastfeeding on the protective effect on asthma has been studied extensively but remains controversial. Studies regarding the effect of breastfeeding on lung function have also been conflicting. The aim of this study was to determine the influence of breastfeeding on lung function in asthmatic children. We included 555 patients who visited Severance Children's Hospital Allergy Clinic with asthma.

A practical approach to vitamin and mineral supplementation in food allergic children

Research

Rosan Meyer^1*, Claire De Koker², Robert Dziubak¹, Ana-Kristina Skrapac², Heather Godwin¹, Kate Reeve¹, Adriana Chebar-Lozinsky¹ and Neil Shah¹³Clinical and Translational Allergy 2015, 5:11  doi:10.1186/s13601-015-0054-y

Abstract (provisional)

Background The management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management.

Chronic urticaria in adults: state-of-the-art in the new millennium

• An Bras Dermatol
• v.90(1); Jan-Feb 2015
• PMC4323701

An Bras Dermatol. 2015 Jan-Feb; 90(1): 74–89.

doi:  10.1590/abd1806-4841.20153509

Paulo Ricardo Criado,1 Roberta Facchini Jardim Criado,2 Celina Wakisaka Maruta,1 and Vitor Manoel Silva dos Reis1Author information ► Article notes ► Copyright and License information ►
Keywords: Angioedema, Biological factors, Colchicine, Cyclosporine, Dapsone, Immunosuppressive agents, Urticaria

Abstract

Chronic urticaria has been explored in several investigative aspects in the new millennium, either as to its pathogenesis, its stand as an autoimmune or auto-reactive disease, the correlation with HLA-linked genetic factors, especially with class II or its interrelation with the coagulation and fibrinolysis systems.

Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

Research

Christoffer V Nissen, Carsten Bindslev-Jensen and Charlotte G Mortz^*

Clinical and Translational Allergy 2015, 5:10  doi:10.1186/s13601-015-0052-0

Abstract (provisional)

Background Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA2LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system. 

Methods Patients with a clinical history of NSAID hypersensitivity referred to the Allergy Centre, Odense University Hospital between 2002 and 2011 and evaluated with oral provocation tests (OPTs) were included in the study. Medical records were retrospectively investigated with respect to the culprit NSAID(s), underlying diseases and symptoms at the primary reaction and during oral provocation tests (OPTs). Data was supplemented with a questionnaire. Classification according to EAACI guideline was based on these findings. 

Results In total 149 patients were included. Of those, 39 patients (26.2%) had a positive OPT. Twenty-nine patients were classified as cross-reactive responders and 9 patients as single NSAID responders after positive OPTs with the culprit NSAID, but not to acetylsalicylic acid. All single NSAID responders reacted to non-pyrazolone drugs. Only one patient could not be classified according to the EAACI/ENDA system. An overlap between respiratory and cutaneous symptoms was found in 15/39 (38%) of patients. 

Conclusions All but one of our patients could be classified according to the EAACI classification system. Overlaps between different classes may occur much more commonly than expected.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.