Vaccination in children with allergy to non active vaccine components

Review

Fabrizio Franceschini¹, Paolo Bottau², Silvia Caimmi³, Giuseppe Crisafulli⁴, Liotti Lucia⁵, Diego Peroni⁶, Francesca Saretta⁷, Mario Vernich⁸, Carlotta Povesi Dascola⁹ and Carlo Caffarelli^10*

Clinical and Translational Medicine 2015, 4:3  doi:10.1186/s40169-014-0043-0

Abstract

Childhood immunisation is one of the greatest public health successes of the last century. Vaccines contain an active component (the antigen) which induces the immune response. They may also contain additional components such as preservatives, additives, adjuvants and traces of other substances.

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities

Review

Erika Jensen-Jarolim^1*, Lukas Einhorn¹, Ina Herrmann², Johann G Thalhammer² and Lucia Panakova²

Clinical and Translational Allergy 2015, 5:15  doi:10.1186/s13601-015-0059-6

Abstract

Both humans and their most important domestic animals harbor IgE and a similar IgE receptor repertoire and expression pattern. The same cell types are also involved in the triggering or regulation of allergies, such as mast cells, eosinophils or T-regulatory cells. Translational clinical studies in domestic animals could therefore help cure animal allergies and at the same time gather knowledge relevant to human patients.

A laboratory test based on determination of cytokine profiles: a promising assay to identify exposition to contact allergens and predict the clinical outcome in occupational allergic contact dermatitis

Methodology article

Valentina Bordignon^1*, Francesca Palamara², Giorgia Altomonte², Isabella Sperduti³, Mario Pietravalle¹, Claudia Cavallotti⁴, Paola Cordiali-Fei¹, Maria Pia Fuggetta⁵, Antonio Cristaudo² and Fabrizio Ensoli¹

BMC Immunology 2015, 16:4  doi:10.1186/s12865-015-0066-3

Abstract

Background

Para-phenylenediamine (PPD) is the main allergen causing adverse reactions to hair dyes and a frequent cause of occupational-related skin sensitization among hairdressers and beauticians. The immunologic mechanism of the disease relies on the production of inflammatory cytokines by allergen-specific T cells, while regulatory T cells are thought to down-modulate the allergic response. This study was aimed at investigating the expression of effector or regulatory cytokines in exposed subjects in order to verify whether different cytokine profiles might predict distinct clinical outcomes.

Latest Article Alert from World Allergy Organization Journal

The following new articles have just been published in World Allergy Organization Journal For articles using Author Version-first publication you will see a provisional PDF corresponding to the accepted manuscript. In these instances, the fully formatted Final Version PDF and full text (HTML) versions will follow in due course.

The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies

Review

Satoru Mihara¹ and Takayuki Shibamoto^2*

Allergy, Asthma & Clinical Immunology 2015, 11:11  doi:10.1186/s13223-015-0074-0

Abstract (provisional)

TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are known to activate TRPA1 by forming a Michael addition product with a cysteine residue of TRPA1 through covalent protein modification and, in consequence, to cause allergic reactions. The anti-allergic property of TRPA1 agonists may be due to the activation and subsequent desensitization of TRPA1 expressed in sensory neurons. In this review, naturally occurring TRPA1 antagonists, such as camphor, 1,8-cineole, menthol, borneol, fenchyl alcohol and 2-methylisoborneol, and TRPA1 agonists, including thymol, carvacrol, 1’S-1’- acetoxychavicol acetate, cinnamaldehyde, α-n-hexyl cinnamic aldehyde and thymoquinone as well as isothiocyanates and sulfides are discussed.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Allergy to cooked, but not raw, peas: a case series and review

Case report

Published: 15 March 2015
 

Elissa M Abrams^* and Thomas V Gerstner

Allergy, Asthma & Clinical Immunology 2015, 11:10  doi:10.1186/s13223-015-0077-x

Abstract

Allergic reactions to legumes are common.Food allergy to cooked, but not raw, pea has been rarely reported in the literature. This case series describes five children who had various IgE-mediated symptoms upon consumption of cooked pea, but tolerated raw pea. Skin testing then confirmed positive responses to cooked, but not raw, peas. It is important to consider allergy to cooked legumes, even in the context of raw legume tolerance.

Keywords:Food allergy; Pea; Legume 

Viewing options

• Full text
• PDF(303KB)
• Additional files

Single NSAID hypersensitivity is associated with atopic status

Volume 47 n. 2/2015  March 2015

R. Asero
Background: The relationship between hypersensitivity to NSAID and atopic status is still incompletely defined. Previous studies found a high prevalence of atopic diseases in multiple NSAID reactors. The present study aimed to investigate whether this is the case also in Italian adults hypersensitive to NSAIDs. Methods: Skin tests with a large panel of seasonal and perennial airborne allergens were carried out in 252 patients with a clear-cut history of acute urticaria induced by nonsteroidal anti-inflammatory drugs. Patients were classified as single or multiple NSAID reactors based on clinical history, presence/absence of chronic urticaria, re-challenge with the reported offending drug in case of doubt history, and oral challenges with aspirin or propionic acid derivatives. Results: Single NSAID reactors showed a much higher prevalence of atopic diseases than multiple NSAID reactors either with or without chronic urticaria (61% vs 19% and 19%, respectively; p < 0.001). Conclusion: As a difference from previous reports, in Italian patients hypersensitive to NSAID atopy is much more prevalent among single reactors, a finding that indirectly supports the possible IgE-mediated origin of this type of adverse drug reaction.

 FULL TEXT

The long-acting β2-agonist olodaterol attenuates pulmonary inflammation

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future) 

British Journal of Pharmacology

1. Eva Wex^1,*, 
2. Ines Kollak¹, 
3. Matthias J Duechs¹, 
4. Emmanuel Naline², 
5. Lutz Wollin¹and
6. Philippe Devillier²
DOI: 10.1111/bph.13143

Abstract
Background and purpose

β₂-agonists are widely used in the management of obstructive airway diseases. Besides their bronchodilatory effect several studies suggest inhibitory effects on various aspects of inflammation. The aim of our study was to determine the efficacy of the long-acting β₂-agonist olodaterol to inhibit pulmonary inflammation and to shed light on its anti-inflammatory mechanism of action.