The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together

Thorax doi:10.1136/thoraxjnl-2015-206781

• Chest clinic

• Audit, research and guideline update

1. Adnan Custovic1, 
2. John Ainsworth2, 
3. Hasan Arshad3,4,5, 
4. Christopher Bishop6, 
5. Iain Buchan2,
6. Paul Cullinan7, 
7. Graham Devereux8, 
8. John Henderson9, 
9. John Holloway4,
10. Graham Roberts3,5,10, 
11. Steve Turner8, 
12. Ashley Woodcock1, 
13. Angela Simpson1

+¹Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK
²Centre for Health Informatics, Institute of Population Health, University of Manchester, Manchester, UK
³David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, UK
⁴Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK
⁵NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
⁶Microsoft Research Cambridge, Cambridge, UK
⁷Imperial College, London, UK
⁸Child Health, University of Aberdeen, Aberdeen, UK
⁹School of Social and Community Medicine, University of Bristol, Bristol, UK
¹⁰Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK

1. Correspondence to Professor Adnan Custovic, University of Manchester, University Hospital of South Manchester, Manchester M23 9LT, UK; adnan.custovic@manchester.ac.uk

Abstract

We created Asthma e-Lab, a secure web-based research environment to support consistent recording, description and sharing of data, computational/statistical methods and emerging findings across the five UK birth cohorts. The e-Lab serves as a data repository for our unified dataset and provides the computational resources and a scientific social network to support collaborative research.

Maternal depressive symptoms across early childhood and asthma in school children: findings from a longitudinal Australian population based study

• PLoS One
• v.10(3); 2015
• PMC4374762

PLoS One. 2015; 10(3): e0121459.Published online 2015 Mar 26. doi:  10.1371/journal.pone.0121459PMCID: PMC4374762
Rebecca Giallo,#1,* Salma Bahreinian,#2 Stephanie Brown,#1 Amanda Cooklin,#3 Dawn Kingston,#2 and Anita Kozyrskyj#2
Abstract

There is a growing body of evidence attesting to links between early life exposure to stress and childhood asthma. However, available evidence is largely based on small, genetically high risk samples. The aim of this study was to explore the associations between the course of maternal depressive symptoms across early childhood and childhood asthma in a nationally representative longitudinal cohort study of Australian children.

New Anti Asthma Drug?

In the following video, Prof. Riccardi and colleagues talk about their findings and a patient with asthma describes her excitement about the potential implications.

Sci Transl Med 22 April 2015: Vol. 7, Issue 284, p. 284ra60 Sci. Transl. Med. DOI: 10.1126/scitranslmed.aaa0282

• RESEARCH ARTICLE

ASTHMA

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

1. Polina L. Yarova1,*, 
2. Alecia L. Stewart2,*, 
3. Venkatachalem Sathish2,*, 
4. Rodney D. Britt Jr.2,*,
5. Michael A. Thompson2, 
6. Alexander P. P. Lowe4, 
7. Michelle Freeman2, 
8. Bharathi Aravamudan2,
9. Hirohito Kita3, 
10. Sarah C. Brennan1, 
11. Martin Schepelmann1, 
12. Thomas Davies1, 
13. Sun Yung1,
14. Zakky Cholisoh4, 
15. Emma J. Kidd4, 
16. William R. Ford4, 
17. Kenneth J. Broadley4, 
18. Katja Rietdorf5,
19. Wenhan Chang6, 
20. Mohd E. Bin Khayat7, 
21. Donald T. Ward7, 
22. Christopher J. Corrigan8,
23. Jeremy P. T. Ward8, 
24. Paul J. Kemp1, 
25. Christina M. Pabelick2, 
26. Y. S. Prakash2,† and 
27. Daniela Riccardi1,†