A blog that publishes updates and open access scientific papers about allergy, asthma and immunology. Editor: Juan Carlos Ivancevich, MD. Specialist in Allergy & Immunology
May 7, 2015
May 5, 2015
The value of pre- and co-seasonal sublingual immunotherapy in pollen-induced allergic rhinoconjunctivitis
Abstract
Allergen immunotherapy (AIT) is a guidelines-approved, disease-modifying treatment option for respiratory allergies, including allergic rhinitis (AR) induced by pollen. The various AIT regimens employed to date in pollen-induced AR can be classified as continuous (i.e. year-round) or discontinuous (i.e. pre-seasonal alone, co-seasonal alone or pre- and co-seasonal). Pre-and co-seasonal regimens are typically used for sublingual allergen immunotherapy (SLIT) and have economic and compliance advantages over perennial (year-round) regimens. However, these advantages must not come at the expensive of poor efficacy or safety.
Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal Type 2 signalling? The MeDALL hypothesis
Allergy (Open access)
Abstract
Allergic diseases (asthma, rhinitis and atopic dermatitis) are complex. They are associated with allergen-specific IgE and non-allergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono or polysensitized subjects.
May 3, 2015
Prospective adherence to specific immunotherapy in Europe (PASTE) survey protocol
Study protocol
Melina Makatsori12*, Gianenrico Senna3, Constantinos Pitsios4, Ramon Lleonart5, Ludger Klimek6, Carlos Nunes7,Maia Rukhadze8, Barbara Rogala9, Radoslaw Gawlik9, Petr Panzner10, Oliver Pfaar116 and Moises Calderon12
Abstract
Background
Adherence to allergen immunotherapy is important for its effectiveness. There is currently limited data available on allergen immunotherapy adherence outside of clinical trials i.e. in real-life clinical practice. As part of a European Academy of Allergy and Clinical Immunology Immunotherapy Interest group initiative, we endeavoured to design a survey in order to prospectively evaluate adherence to subcutaneous and sublingual immunotherapy across different European countries.
Chronic vulvovaginal Candida hypersensitivity: An underrecognized and undertreated disorder by allergists
Bernstein, Jonathan A.; Seidu, Luqman
Abstract:
Vulvovaginal candidiasis infections are estimated to occur at least once during the lifetime of 75% of the female population. It has been proposed that some women with recurrent vulvovaginal candidiasis (RVVC) develop sensitization to Candida albicans and clinically improve in response to Candida immunotherapy.
Patients’ perspective of barriers and facilitators to taking long-term controller medication for asthma: a novel taxonomy
Research article
Sandra Peláez1, Alexandrine J Lamontagne1, Johanne Collin2, Annie Gauthier1, Roland M Grad3, Lucie Blais2, Kim L Lavoie4, Simon L Bacon5, Pierre Ernst67, Hélène Guay8, Martha L McKinney9 and Francine M Ducharme1101179*
Abstract (provisional)
Background Although asthma morbidity can be prevented through long-term controller medication, most patients with persistent asthma do not take their daily inhaled corticosteroid. The objective of this study was to gather patients’ insights into barriers and facilitators to taking long-term daily inhaled corticosteroids as basis for future knowledge translation interventions.
Effectiveness of Montelukast on asthma control in infants: methodology of a French claims data study
Background This pilot study, conducted on a 1/97th representative sample of French claims data, prepared a project to assess the effectiveness of Montelukast (MTL-4) as add-on therapy for asthma in infants (6–24 months) compared to inhaled corticosteroids (ICS), based on real-world data. Due to the very recent opening of French claims data for effectiveness research, and the complex structure of this data source, we first tested the feasibility of identifying infants with asthma and outcome criteria, and the ability to perform relevant comparisons.
Practical recommendations for mixing allergy immunotherapy extracts
Daigle, Barbara J.; Rekkerth, Donna J.
Abstract:
Critical aspects of formulating allergy immunotherapy vaccines include the selection, total number, and proportions of each allergen component in therapeutic mixtures. The immunotherapy prescription, determined by a medical provider, details the dosing and schedule for treatment as well as the specific composition of the treatment vials.
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