Epidemiology of Anaphylaxis: Contributions From the Last 10 Years

Tejedor-Alonso MA1,2, Moro-Moro M1, Múgica-García MV3

1Allergy Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain 2Medicine and Surgery Department, Universidad Rey Juan Carlos, Alcorcón, Spain 3Allergy Service, Hospital Universitario de la Princesa, Madrid, Spain

J Investig Allergol Clin Immunol 2015; Vol. 25(3): 163-175

Abstract Knowledge of the epidemiology of anaphylaxis has improved during the last 10 years thanks to the increased number of publications with improved methodological robustness. Consequently, we better understand the distribution and frequency of anaphylaxis and the characteristics of fatal anaphylaxis.

Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study

Research article

Ming Zeng, Zhi-Yong Li, Jin Ma, Ping-Ping Cao, Heng Wang, Yong-Hua Cui and Zheng Liu^*

BMC Immunology 2015, 16:37  doi:10.1186/s12865-015-0096-x

Abstract

Background

Phenotype of chronic rhinosinusitis (CRS) may be an important determining factor of the efficacy of anti-inflammatory treatments. Although both glucocorticoids and macrolide antibiotics have been recommended for the treatment of CRS, whether they have different anti-inflammatory functions for distinct phenotypic CRS has not been completely understood. The aim of this study is to compare the anti-inflammatory effects of clarithromycin and dexamethasone on sinonasal mucosal explants from different phenotypic CRS ex vivo.

Allergy immunotherapy prescribing trends for grass pollen-induced allergic rhinitis in Germany: a retrospective cohort analysis

Research

Amanda L. McDonell^1*, Ulrich Wahn², Dirk Demuth¹, Catrina Richards¹, Charlie Hawes³, Jakob Nørgaard Andreasen⁴and Felicia Allen-Ramey⁵

Allergy, Asthma & Clinical Immunology 2015, 11:19  doi:10.1186/s13223-015-0085-x

Abstract (provisional)

Background Allergy immunotherapy is an effective treatment for patients with allergic rhinitis whose symptoms are unresolved with pharmacotherapy. Allergy immunotherapy for grass pollen-induced allergic rhinitis is available in three modalities: subcutaneous immunotherapy and sublingual immunotherapy as a tablet or drop. This study aimed to understand trends in allergy immunotherapy prescribing and practice patterns for grass allergies in adult and paediatric patients in Germany.

CSACI position statement: epinephrine auto-injectors and children less than 15 kg

Michelle Halbrich^1*, Douglas P. Mack², Stuart Carr³, Wade Watson⁴ and Harold Kim⁵⁶

Allergy, Asthma & Clinical Immunology 2015, 11:20  doi:10.1186/s13223-015-0086-9

Abstract (provisional)

Epinephrine (adrenaline) is the treatment of choice for anaphylaxis. While other medications, including H1-antihistamines, H2-antihistamines, corticosteroids, and inhaled beta-2 agonists are often used to treat anaphylaxis in the emergency setting, none of these medications has been shown to reverse anaphylaxis. Fatal anaphylaxis is related to the delayed use of epinephrine. In community settings, epinephrine is available as an auto-injector in two doses, 0.15 mg and 0.3 mg.

Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects

	Yonsei Med J > v.56(4); Jul 2015 Review Article  Open Access
	Jong-Uk Lee,1 Jeong Dong Kim,1 and Choon-Sik Park2 1Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Korea. 2Genome Research Center and Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.  Corresponding author: Dr. Choon-Sik Park, Genome Research Center and Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea. Tel: 82-32-621-5105, Fax: 82-32-621-5023, Email: mdcspark@daum.net  Abstract Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches including linkage analysis, candidate gene polymorphism studies, and genome-wide association studies (GWAS). However, contrary to general expectation, even single nucleotide polymorphisms (SNPs) discovered by GWAS failed to fully explain the heritability of asthma.

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

Thorax doi:10.1136/thoraxjnl-2014-206719

• Original article
• Nicola A Hanania1, 
• Michael Noonan2, 
• Jonathan Corren3, 
• Phillip Korenblat4, 
• Yanan Zheng5,
• Saloumeh K Fischer5, 
• Melissa Cheu5, 
• Wendy S Putnam5, 
• Elaine Murray5,
• Heleen Scheerens5, 
• Cecile TJ Holweg5, 
• Romeo Maciuca5, 
• Sarah Gray5, 
• Ramona Doyle5,
• Dana McClintock5, 
• Julie Olsson5, 
• John G Matthews5, 
• Karl Yen5

Abstract

Introduction In a subset of patients with asthma, standard-of-care treatment does not achieve disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a humanised, monoclonal antibody that binds to and blocks interleukin-13 activity.

An individualized diagnostic approach based on guidelines for chronic urticaria (CU)

Journal of the European Academy of Dermatology and Venereology

Special Issue: An Overview of the Current Knowledge in Urticaria. Proceedings from the Global Urticaria Forum, November 2014, Prague, Czech Republic

Volume 29, Issue Supplement S3, pages 3–11, June 2015

1. A.M. Giménez-Arnau¹, 
2. C. Grattan², 
3. T. Zuberbier³ and
4. E. Toubi⁴ 

5. 
   

6. Abstract
   Chronic urticaria (CU), defined as the spontaneous or inducible appearance of hives, angioedema or both for 6 weeks or more, presents with a number of subtypes which all substantially impair patients’ quality of life (QoL).

Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

Research

Matt J Silver^12†, Noah J Kessler^3†, Branwen J Hennig¹², Paula Dominguez-Salas⁴⁵, Eleonora Laritsky³, Maria S Baker³, Cristian Coarfa⁶, Hector Hernandez-Vargas⁷, Jovita M Castelino⁸, Michael N Routledge⁸, Yun Yun Gong⁹,Zdenko Herceg⁷, Yong Sun Lee¹⁰, Kwanbok Lee¹⁰, Sophie E Moore¹¹¹², Anthony J Fulford¹², Andrew M Prentice^12*and Robert A Waterland^123*

Genome Biology 2015, 16:118  doi:10.1186/s13059-015-0660-y

Abstract

Background

Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in easily biopsiable tissues. We employ two independent genome-wide approaches to search for such variants.