Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite

Asia Pac Allergy. 2015 Jul;5(3):163-169. English. http://dx.doi.org/10.5415/apallergy.2015.5.3.163

Salvatore Barberi,1 Giorgio Ciprandi,2 Elvira Verduci,1 Enza D'Auria,1 Piercarlo Poli,1 Benedetta Pietra,1Cristoforo Incorvaia,3 Serena Buttafava,4 Franco Frati,4 and Enrica Riva1

1Department of Pediatrics, San Paolo Hospital, 20142 Milan, Italy.

2Department of Medicine, IRCCS-Azienda Ospedaliera Universitaria San Martino, 16132 Genoa, Italy.

3Allergy/Pulmonary Rehabilitation, ICP Hospital, 20100 Milan, Italy.

4Medical and Scientific Department, Stallergenes Italy, 20155 Milan, Italy.

Abstract Background Allergic rhinitis is characterized by eosinophil inflammation. Allergic inflammation may induce susceptibility to respiratory infections (RI). House dust mite (HDM) sensitization is very frequent in childhood. Allergen immunotherapy may cure allergy as it restores a physiologic immune and clinical tolerance to allergen and exerts anti-inflammatory activity.

Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial

Research article

Melanie Rae Simpson^1*, Christian Kvikne Dotterud¹², Ola Storrø¹, Roar Johnsen¹ and Torbjørn Øien¹

BMC Dermatology 2015, 15:13  doi:10.1186/s12895-015-0030-1

Abstract

Background

Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.

Malaria eradication and elimination: views on how to translate a vision into reality

Forum

Marcel Tanner^12*, Brian Greenwood³, Christopher J M Whitty³, Evelyn K Ansah⁴, Ric N Price⁵⁶, Arjen M Dondorp⁶⁷,Lorenz von Seidlein⁶⁷, J Kevin Baird⁶⁸, James G Beeson¹⁰⁹, Freya J I Fowkes^1112139, Janet Hemingway¹⁴, Kevin Marsh¹⁵ and Faith Osier¹⁶

BMC Medicine 2015, 13:167  doi:10.1186/s12916-015-0384-6

Abstract

Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria might eventually be eradicated. Their collective views highlight the challenges and opportunities, and explain how multi-factorial and integrated processes could eventually make malaria eradication a reality.

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Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study

PLoS One. 2015 Aug 26;10(8):e0136191. doi: 10.1371/journal.pone.0136191. eCollection 2015.

Burte E1, Bousquet J2, Varraso R1, Gormand F3, Just J4, Matran R5, Pin I6, Siroux V7, Jacquemin B8, Nadif R1.

Abstract

Background

The classification of rhinitis in adults is missing in epidemiological studies.

Objective

To identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.

Methods

983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used.

Immunological events in chronic spontaneous urticaria

Review

Marta Ferrer

Clinical and Translational Allergy 2015, 5:30  doi:10.1186/s13601-015-0074-7

Published: 25 August 2015

Abstract

Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35–40% of patients.

Does the Maternal Serum IgG Level during Pregnancy in Primary Antibody Deficiency Influence the IgG Level in the Newborn?

Case Reports in Immunology
Volume 2015 (2015), Article ID 286380, 4 pages
http://dx.doi.org/10.1155/2015/286380

Case Report

Vasantha Nagendran,1,2 Noel Emmanuel,3 and Amolak S. Bansal1

1Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey SM5 1AA, UK
2St Georges University of London, London SW17 0RE, UK
3St George’s University Hospitals NHS Foundation Trust, Tooting, London SW17 0QT, UK

Received 18 June 2015; Revised 17 August 2015; Accepted 18 August 2015

Abstract

Purpose. To find out if the serum IgG level in the newborn baby was affected by low maternal serum IgG during pregnancy in two newly diagnosed primary antibody deficient patients. 

Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium – an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects

Research article

Annelie F Behndig¹, Karthika Shanmuganathan², Laura Whitmarsh², Nikolai Stenfors¹, Joanna L Brown², Anthony J Frew², Frank J Kelly³, Ian S Mudway³, Thomas Sandström¹ and Susan J Wilson^24*

BMC Pulmonary Medicine 2015, 15:99  doi:10.1186/s12890-015-0096-x

Abstract

Background

Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this effect. Here we investigated whether diesel exhaust (DE) would induce apoptosis or proliferation in the bronchial epithelium in vivo and thus contribute to respiratory symptoms.

Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist’s View

Annals of Dermatology 2015 ; 27(4): 355~363

Dong-Ho Nahm

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

The current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caused by hypersensitivity reaction to environmental inhalant or food allergen.