FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy

Journal of Immunology Research
Volume 2015 (2015), Article ID 731381, 7 pages
http://dx.doi.org/10.1155/2015/731381

Research Article

Anna Stelmaszczyk-Emmel,1 Anna Zawadzka-Krajewska,2 Eliza Głodkowska-Mrówka,1 and Urszula Demkow1

1Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Poland
2Department of Pediatric Pneumonology and Allergology, Medical University of Warsaw, Poland

Abstract

Over the last decades allergic diseases has become a major health problem worldwide. The only specific treatment to date is allergen specific immunotherapy (ASIT). Although it was shown that ASIT generates allergen-tolerant T cells, detailed mechanism underlying its activity is still unclear and there is no reliable method to monitor its effectiveness. The aim of our study was to evaluate ASIT influence on the frequency of forkhead box P3 (FoxP3) Tregs in allergic children with various clinical manifestations.

Review on immunotherapy in airway allergen sensitised patients.

Neth J Med. 2015 Jul;73(6):263-9.

van der Valk JP1, de Jong NW, Gerth van Wijk R.

Author information

Abstract

Allergen immunotherapy is a more than 100-year-old treatment in particular for birch pollen, grass pollen, house dust mite and cat dander sensitised allergic patients. The mechanism of allergen-specific immunotherapy is complex. Different hypotheses have been postulated to explain the mode of action, such as a decrease of the number of tissue mast cells, eosinophils and basophils, an increase of IgG4 and IgA synthesis, a shift from Th2 to Th1 cells and an increase in the number and function of IL-10 producing T-regulatory cells (T-reg).

Towards a Clinical Decision Support System for Drug Allergy Management: Are Existing Drug Reference Terminologies Sufficient for Identifying Substitutes and Cross-Reactants?

Authors

William Ogallo, Andrew S. Kanter

Pages

1088 - 1088

DOI

10.3233/978-1-61499-564-7-1088

Series

Studies in Health Technology and Informatics

Ebook

Volume 216: MEDINFO 2015: eHealth-enabled Health

Abstract

Drug allergy cross-reactivity checking is an important component of electronic health record systems. Currently, a single, open-source medication dictionary that can provide this function does not exist. In this study, we assessed the feasibility of using RxNorm and NDF-RT (National Drug File – Reference Terminology) for allergy management decision support.

Allergy Risk Finder: Hypothesis Generation System for Allergy Risks via Web Service

Authors

Eiji Aramaki, Shuko Shikata, Eriko Watabe, Mai Miyabe, Yasuyuki Usuda, Satsuki Ayaya, Shinichiro Kumagaya

Pages

1113 - 1113

DOI

10.3233/978-1-61499-564-7-1113

Series

Studies in Health Technology and Informatics

Ebook

Volume 216: MEDINFO 2015: eHealth-enabled Health

Abstract

This study's aim was to build a web service that automatically collects and tests hypotheses for possible allergy risks.

An eHealth Approach to Reporting Allergic Reactions to Food and Closing the Knowledge Gap

Authors

Christopher Munro, Aida Semic-Jusufagic, Katarzyna Pyrz, Philip Couch, Audrey Dunn-Galvin, Niels Peek, Marina Themis, Clare Mills, Iain Buchan, Jonathan Hourihane, Angela Simpson

Pages

320 - 324

DOI

10.3233/978-1-61499-564-7-320

Series

Studies in Health Technology and Informatics

Ebook

Volume 216: MEDINFO 2015: eHealth-enabled Health

Abstract

There is an important knowledge gap in food allergy management in understanding the factors that determine allergic reactions to food, in gathering objective reports of reactions in real time, and in accessing patients' reaction-histories during consultations.

To Assess the Quality of Life in Patients Suffering from Allergic Rhinitis

Journal of Basic & Applied Sciences- Medical Sciences Pages 501-506 Nikhil Sharma, Prithpal S. Matreja, Monika Gupta, Vipan Gupta,Manish Gupta and Ashwani K. Gupta DOI: http://dx.doi.org/10.6000/1927-5129.2015.11.67

Abstract: Background: Allergic Rhinitis (AR) associated with impairments in patients day-to-day functioning at home and work is a global health problem. It’s associated with sleep disorders, emotional problems, impairment in activities, and social functioning. However, it’s not known to what extent quality of life (QOL) scores, work impairment, or sleep is altered in Indian setup hence, this study was designed to assess the quality of life of patients suffering from allergic rhinitis.

Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps?

Research

Mona-Rita Yacoub^12*, Matteo Trimarchi¹², George Cremona¹², Sara Dal Farra¹², Giuseppe Alvise Ramirez¹², Valentina Canti¹², Emanuel Della Torre¹², Mattia Baldini¹², Patrizia Pignatti³, Mario Bussi¹², Maria Grazia Sabbadini¹², Angelo A Manfredi¹² and Giselda Colombo¹²

Clinical and Molecular Allergy 2015, 13:23  doi:10.1186/s12948-015-0026-8

Abstract

Background

The aetiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is still unknown. The role of atopy and the concept of united airways in such patients are still a matter of debate. In this pilot study we aimed at evaluating the degree of eosinophilic inflammation and the frequency of atopy in a cohort of CRSwNP patients candidate for Functional Endoscopic Sinus Surgery (FESS) and assessing the association between these factors and relapsing forms of CRSwNP.

The adsorption of allergoids and 3-O-desacyl-4′-monophosphoryl lipid A (MPL®) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

Journal of Inorganic Biochemistry

In Press, Corrected Proof — Note to users

• A.J. Bell, 
• M.D. Heath, 
• S.J. Hewings, 
• M.A. Skinner

Under a Creative Commons license

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doi:10.1016/j.jinorgbio.2015.08.007

 Open Access

Highlights

•

Vaccine potency is affected by antigen-adjuvant adsorption.

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MATA-MPL immunotherapy formulations effectively treat IgE mitigated allergy.

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Allergoids & MPL® are consistently adsorbed in MATA-MPL formulations.

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Adsorption of MPL® to MCT could be influenced by C–H · · · ·π interactions.

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MCT could be an alternative adjuvant depot for infectious disease antigens.

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Abstract

Infectious disease vaccine potency is affected by antigen adjuvant adsorption. WHO and EMA guidelines recommend limits and experimental monitoring of adsorption in vaccines and allergy immunotherapies. Adsorbed allergoids and MPL® in MATA-MPL allergy immunotherapy formulations effectively treat IgE mitigated allergy. Understanding vaccine antigen adjuvant adsorption allows optimisation of potency and should be seen as good practice; however current understanding is seldom applied to allergy immunotherapies.