Sleep Apnea Clinical Score, Berlin Questionnaire, or Epworth Sleepiness Scale: which is the best obstructive sleep apnea predictor in patients with COPD?

ORIGINAL RESEARCH

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Anamelia Costa Faria, Cláudia Henrique da Costa, Rogério Rufino

Cardiopulmonology Department, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Introduction: The Sleep Apnea Clinical Score (SACS) and the Berlin Questionnaire (BQ) are used to predict the likelihood of obstructive sleep apnea (OSA). The Epworth Sleepiness Scale (ESS) is used to assess daytime sleepiness, a common OSA symptom. These clinical tools help prioritize individuals with the most severe illness regarding on whom polysomnography (PSG) should be performed. It is necessary to check the applicability of these tools in patients with chronic obstructive pulmonary disease (COPD). The aim of this study is to compare SACS, BQ, and ESS performance in patients with COPD.

Using magnetic resonance imaging to quantify the inflammatory response following allergen challenge in allergic rhinitis

Immunity, Inflammation and Disease

Early View (Online Version of Record published before inclusion in an issue)

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Keywords:

• Acoustic rhinometry;
• allergic rhinitis;
• MRI;
• nasal allergen challenge

Abstract

Current rhinometric and flow assessments measure nasal patency and are often poorly correlated with rhinitis symptoms. To evaluate magnetic resonance imaging (MRI) as a new method to measure inflammatory changes in nasal and sinus mucosa following nasal allergen challenge.

Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

The ISME Journal advance online publication, 22 September 2015; doi:10.1038/ismej.2015.151

OPEN

Roberto Berni Canani^1,8, Naseer Sangwan^2,8, Andrew T Stefka^3,8, Rita Nocerino¹, Lorella Paparo¹, Rosita Aitoro¹, Antonio Calignano⁴, Aly A Khan⁵, Jack A Gilbert^2,6,7and Cathryn R Nagler³

1. ¹Department of Translational Medical Science, Section of Pediatrics, European Laboratory for the Investigation of Food-Induced Diseases, University of Naples, Federico II, Naples, Italy
2. ²Institute for Genomics and Systems Biology, Department of Biosciences, Argonne National Laboratory, Argonne, IL, USA
3. ³Committee on Immunology and Department of Pathology, University of Chicago, Chicago, IL, USA
4. ⁴Department of Pharmacy, University of Naples Federico II, Naples, Italy
5. ⁵Toyota Technological Institute at Chicago, Chicago, IL, USA
6. ⁶Department of Surgery, University of Chicago, Chicago, IL, USA
7. ⁷Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA

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Abstract

Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow’s milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based operational taxonomic unit clustering and oligotyping.

Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study

BioMed Research International

Volume 2015 (2015), Article ID 584291, 11 pages

http://dx.doi.org/10.1155/2015/584291

Research Article

Oliver Pfaar,1,2 Heinz-Gerd Richter,3 Ludger Klimek,1 Jochen Sieber,4 Meike Hadler,4 and Efstrathios Karagiannis4

Abstract

Background. Although the safety and efficacy of sublingual immunotherapy (SLIT) with a five-grass pollen tablet have been demonstrated in randomized clinical trials (RCTs), these outcomes must always be evaluated in real-life medical practice. 

Severe Asthma: Definition, Diagnosis and Treatment

• Dtsch Arztebl Int
• v.111(50); 2014 Dec
• PMC4357024

Dtsch Arztebl Int. 2014 Dec; 111(50): 847–855.

PMCID: PMC4357024

Review Article

Marek Lommatzsch, Prof. Dr. med.*,1 and Christian J Virchow, Prof. Dr. med.1

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

A minority of patients with asthma have uncontrolled or partially controlled asthma despite intensive treatment. These patients present a special challenge because of the extensive diagnostic evaluation that they need, insufficient evidence regarding personalized treatments, and their high consumption of health-care resources.

Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin Era

Journal of Allergy
Volume 2015 (2015), Article ID 902359, 7 pageshttp://dx.doi.org/10.1155/2015/902359Review ArticleCamilla Elmose1 and Simon Francis Thomsen1,2

1Department of Dermatology, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
2Center for Medical Research Methodology, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark

Abstract

Aim. The aim of this study was to conduct a systematic review of population-based twin studies of (a) the concordance and heritability of AD and (b) the relationship between AD and asthma and, furthermore, to reinterpret findings from previous twin studies in the light of the emerging knowledge about filaggrin and its role in the atopic march and provide suggestions for future research in this area.

Rituximab in refractory sarcoidosis: a single centre experience

Case Report

Francesco Cinetto, Nicolò Compagno, Riccardo Scarpa, Giacomo Malipiero and Carlo Agostini^*

Clinical and Molecular Allergy 2015, 13:19  doi:10.1186/s12948-015-0025-9

Abstract

Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune suppressants drugs are currently used in the disease management. However, refractory disease is still a great challenge. Rituximab is an anti-CD20 chimeric monoclonal antibody, currently used for the treatment of B cell malignancies and systemic autoimmune diseases.

High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?

Journal of Immunology Research
Volume 2015 (2015), Article ID 902863, 8 pages
http://dx.doi.org/10.1155/2015/902863

Research Article

Alena Sekerkova,1 Martin Fuchs,2 Eva Cecrdlova,1 Veronika Svachova,1 Ivana Kralova Lesna,3 Ilja Striz,1 and Helena Tlaskalova-Hogenova4

1Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
2Immunoflow, 199 00 Prague, Czech Republic
3Laboratory for Artherosclerosis Research, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
4Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, ASCR, 142 00 Prague, Czech Republic

Abstract

Background. Food protein-induced proctitis/proctocolitis (FPIP) is the most common noninfectious colitis in children in the first year of life. Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease.