Attenuated Allergenic Activity of Ovomucoid After Electrolysis

Allergy Asthma Immunol Res > v.7(6); Nov 2015   Brief Communication  Open Access Jun Kido,1,2 and Tomoaki Matsumoto1,3,4 1Department of Pediatrics, Kumamoto Regional Medical Center, Kumamoto City, Kumamoto, Japan. 2Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Kumamoto, Japan. 3Department of Child Development, Kumamoto University Hospital, Kumamoto City, Kumamoto, Japan. 4Pediatric Division, Aso Spa Hospital, Aso City, Kumamoto, Japan. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Ovomucoid (OMC) is the most prominent allergen causing hen's egg allergy, containing disulfide (S-S) bonds that may be responsible for its allergic action. As S-S bonds may be reduced during electrolysis, this study was undertaken to evaluate modulation of the allergic action of OMC after electrolysis. Electrolysis was carried out for 1% OMC containing 1% sodium chloride for 30 minutes with a voltage difference of 90 V, 0.23 A (30 mA/cm2).

The role of IL-33 and mast cells in allergy and inflammation

Review

Rohit Saluja^134*, Mahejibin Khan², Martin K. Church¹ and Marcus Maurer^1*

Clinical and Translational Allergy 2015, 5:33  doi:10.1186/s13601-015-0076-5

Abstract

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and smooth muscle cells. During necrosis of these cells (after tissue injury or cell damage), the IL-33 that is released may be recognized by different types of immune cells, such as eosinophils, basophils and, especially, mast cells.

AIT (allergen immunotherapy): a model for the “precision medicine”

Commentary

Giovanni Passalacqua^* and Giorgio Walter Canonica

Clinical and Molecular Allergy 2015, 13:24  doi:10.1186/s12948-015-0028-6

Abstract

The interpretation of medical approaches, especially therapy, evolved rapidly in the last century. Starting from the simple description of symptoms, we moved to the pathophysiological descriptions, to the evidence-based medicine, until the so-called “precision medicine”. This latter can be defined as a structural model aimed at customizing healthcare, with medical decisions/products tailored on an individual patient at a highly detailed level.

Angioedema induced by cardiovascular drugs: new players join old friends

Review Article

You have free access to this content

Allergy Volume 70, Issue 10, pages 1196–1200, October 2015

1. M. Bas¹, 
2. J. Greve², 
3. U. Strassen¹, 
4. F. Khosravani³, 
5. T. K. Hoffmann² and
6. G. Kojda^3,*

Abstract

During the last years, two new cardiovascular drug classes, namely inhibitors of DPP IV or neprilysin, have been developed. In both cases, there is clinical evidence for their potential to induce angioedema as known already from blockers of the renin–angiotensin–aldosterone system (RAAS).

Pathophysiological mechanisms of exercise-induced anaphylaxis: an EAACI position statement

Allergy Volume 70, Issue 10, pages 1212–1221, October 2015

L. Ansley^1,*, 

M. Bonini², 

L. Delgado³, 

S. Del Giacco⁴, 

G. Du Toit⁵, 

M. Khaitov⁶, 

M. Kurowski⁷, 

J. H. Hull⁸, 

A. Moreira³ and

P. J. Robson-Ansley¹

Abstract

This document is the result of a consensus on the mechanisms of exercise-induced anaphylaxis (EIAn), an unpredictable and potentially fatal syndrome. A multidisciplinary panel of experts including exercise physiologists, allergists, lung physicians, paediatricians and a biostatistician reached the given consensus.

Association Between Neonatal Urinary Tract Infection and Risk of Childhood Allergic Rhinitis

Medicine Vol. 94 - Issue 38: p e1625, 2015

Lin, Chien-Heng MD; Lin, Wei-Ching MD; Wang, Yu-Chiao MSc; Lin, I. Ching MD, MS, PhD; Kao, Chia-Hung MD

Abstract: The current population-based study investigated the onset of neonatal urinary tract infection (UTI) and the associated risks of allergic rhinitis.

From 2000 to 2005, 3285 children with neonatal UTI and 13,128 randomly selected controls were enrolled from the National Health Insurance Research Database in Taiwan and frequency matched by gender, urbanization of residential area, parental occupation, and baseline year. We compared the risk of allergic rhinitis between the non-UTI and UTI cohorts by performing multivariable Cox regression analysis.

H1 Antihistamines’ effect on pro-inflammatory Cytokines in allergic rhinitis to house dust mites

August 2015 Volume 37, Issue 8, Supplement, Pages e106–e107

I.C. Bocsan

,

 I.A. Muntean

,

 S. Vesa

,

 D. Deleanu

,

 A.D. Buzoianu

University of Medicine and Pharmacy, Cluj Napoca, Romania

Article Info

• Abstract
• Full Text

Allergic rhinitis to house dust mites is characterized by a chronic inflammation of nasal mucosa. H1 antihistamines from second generation reduce the rhinitis’ symptoms, but may also have anti-inflammatory properties.

The Association of BCG Vaccination with Atopy and Asthma in Adults

Int J Med Sci 2015; 12(8):668-673. doi:10.7150/ijms.12233

Research Paper

Sung Soo Park¹, Eun Young Heo¹, Deog Kyeom Kim¹, Hee Soon Chung¹, Chang-Hoon Lee^1,2 

1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical center, Seoul, Republic of Korea
2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea

How to cite this article:
Park SS, Heo EY, Kim DK, Chung HS, Lee CH. The Association of BCG Vaccination with Atopy and Asthma in Adults. Int J Med Sci 2015; 12(8):668-673. doi:10.7150/ijms.12233. Available from http://www.medsci.org/v12p0668.htm

Abstract

Introduction: There are few studies investigating the association between BCG vaccination and atopy or asthma in adults.

Objective: We investigated the association between BCG scar and the occurrence of atopy and asthma in Korean adults.