Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study

Prof Daniel Kotz, PhD

,

 Wolfgang Viechtbauer, PhD

,

 Colin Simpson, PhD

,

 Prof Onno C P van Schayck, PhD

,

 ProfRobert West, PhD

,

 Prof Aziz Sheikh, MD

Open Access

DOI: http://dx.doi.org/10.1016/S2213-2600(15)00320-3

Open access funded by Medical Research Council

Article Info

• 
  Summary
• Full Text
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Summary

Background

Varenicline is an effective pharmacotherapy to aid smoking cessation. However, its use is limited by continuing concerns about possible associated risks of serious adverse cardiovascular and neuropsychiatric events. The aim of this study was to investigate whether use of varenicline is associated with such events.

Childhood Wheezing, Asthma, Allergy, Atopy, and Lung Function: Different Socioeconomic Patterns for Different Phenotypes

Bruna Galobardes*, 

Raquel Granell, 

Jonathan Sterne, 

Rachael Hughes,

Cilia Mejia-Lancheros, 

George Davey Smith and 

John Henderson

1. ↵*Correspondence to Dr. Bruna Galobardes, University of Bristol, School of Social and Community Medicine, Oakfield House, Oakfield Grove, BS8 2BN, United Kingdom (e-mail:bruna.galobardes@bristol.ac.uk). 

1. Am. J. Epidemiol. (2015) 182 (9):763-774.

1. doi: 10.1093/aje/kwv045

Abstract

Identifying preventable exposures that lead to asthma and associated allergies has proved challenging, partly because of the difficulty in differentiating phenotypes that define homogeneous disease groups. Understanding the socioeconomic patterns of disease phenotypes can help distinguish which exposures are preventable.

The Price of Pruritus. Sleep Disturbance and Cosleeping in Atopic Dermatitis

FREE

Sarah L. Chamlin, MD; Christine L. Mattson, MS; Ilona J. Frieden, MD; Mary L. Williams, MD; Anthony J. Mancini, MD; David Cella, PhD; Mary-Margaret Chren, MD

[+] Author AffiliationsArch Pediatr Adolesc Med. 2005;159(8):745-750. doi:10.1001/archpedi.159.8.745.

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ABSTRACT

ABSTRACT | METHODS | RESULTS | COMMENT | ARTICLE INFORMATION |REFERENCES

Background  Atopic dermatitis is a common skin disorder that most often begins in infancy. Sleep disturbances in children with atopic dermatitis are likely due to itching and scratching and not only impact the afflicted child but may also affect the entire family. Sleep characteristics in young children with atopic dermatitis and their families have not been thoroughly investigated.

Guidelines on the management of IgE-mediated food allergies

November 2015, Volume 24, Issue 7, pp 256-293

S2k-Guidelines of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Medical Association of Allergologists (AeDA), the German Professional Association of Pediatricians (BVKJ), the German Allergy and Asthma Association (DAAB), German Dermatological Society (DDG), the German Society for Nutrition (DGE), the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS), the German Society for Oto-Rhino-Laryngology, Head and Neck Surgery, the German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Society for Pneumology (DGP), the German Society for Pediatric Gastroenterology and Nutrition (GPGE), German Contact Allergy Group (DKG), the Austrian Society for Allergology and Immunology (Æ-GAI), German Professional Association of Nutritional Sciences (VDOE) and the Association of the Scientific Medical Societies Germany (AWMF)

• Margitta Worm 
• , Imke Reese
• , Barbara Ballmer-Weber
• , Kirsten Beyer
• , Stephan C. Bischoff
• ,Martin Classen
• , Peter J. Fischer
• , Thomas Fuchs
• , Isidor Huttegger
•  and 20 more

• Preamble

  The present guideline updates and summarizes S1- and S2-guidelines published by the German Association of Scientific Medical Societies (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF) which have been published on various aspects of food allergy [1, 2, 3, 4, 5, 6,7].

House Dust Mite Respiratory Allergy: An Overview of Current Therapeutic Strategies

Open Access 

November–December, 2015Volume 3, Issue 6, Pages 843–855

Moisés A. Calderón, MD, PhD , 

Jörg Kleine-Tebbe, MD

, Allan Linneberg, MD, PhD, Frédéric De Blay, MD, PhD, 

Dolores Hernandez Fernandez de Rojas, MD, PhD

, Johann Christian Virchow, MD, FRCP, FCCP , Pascal Demoly, MD, PhD

• Abstract
• Full Text
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• References

Although house dust mite (HDM) allergy is a major cause of respiratory allergic disease, specific diagnosis and effective treatment both present unresolved challenges. Guidelines for the treatment of allergic rhinitis and asthma are well supported in the literature, but specific evidence on the efficacy of pharmacotherapy treatment for known HDM-allergic patients is weaker.

Allergen immunotherapy in pregnancy

Review

Paul Oykhman¹, Harold L. Kim²³ and Anne K. Ellis^45*

Allergy, Asthma & Clinical Immunology 2015, 11:31  doi:10.1186/s13223-015-0096-7

Abstract

Background

Allergic diseases such as asthma and allergic rhinitis constitute a significant burden of disease among women of childbearing age and those who are pregnant. Adequately managing these conditions is paramount in reducing negative fetal outcomes as well as maternal complications during pregnancy. However, the potential for harm to both the mother and fetus demands carefully balancing efficacy and safety of treatment. Allergen immunotherapy (AIT) has emerged as a relatively safe and efficacious mode of therapy in both children and adults. AIT has also been considered for use during pregnancy.

The impact of allergic rhinitis on the management of asthma in a working population

Research article

Dorothée Provost^12*, Yuriko Iwatsubo¹, Stéphanie Riviere¹, Maëlaïg Mevel¹, Alain Didier³, Patrick Brochard²⁴, Ellen Imbernon¹ and Chantal Raherison²⁵

BMC Pulmonary Medicine 2015, 15:142  doi:10.1186/s12890-015-0136-6

Abstract

Background

Currently, little data is available about the management of asthma in the working population. The aim of this study was to describe asthma control and severity among workers according to current or previous allergic rhinitis comorbidity.