Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults

November 2015 - Volume 94 - Issue 47 - p e1892

doi: 10.1097/MD.0000000000001892

Dong, Jing PhD; Yang, Jingyun PhD; Tranah, Greg PhD; Franceschini, Nora PhD; Parimi, Neeta PhD; Alkorta-Aranburu, Gorka PhD; Xu, Zongli PhD; Alonso, Alvaro MD, PhD; Cummings, Steven R. PhD; Fornage, Myriam PhD; Huang, Xuemei MD, PhD; Kritchevsky, Stephen PhD; Liu, Yongmei PhD; London, Stephanie MD, DrPH; Niu, Liang PhD; Wilson, Robert S. PhD; De Jager, Philip L. MD, PhD; Yu, Lei PhD; Singleton, Andrew B. PhD; Harris, Tamara MD, MS; Mosley, Thomas H. Jr PhD; Pinto, Jayant M. MD; Bennett, David A. MD; Chen, Honglei MD, PhD

Section Editor(s): Manchia., Mirko

Open Access

Supplemental Author Material

Abstract

Abstract: Olfactory dysfunction is common among older adults and affects their safety, nutrition, quality of life, and mortality. More importantly, the decreased sense of smell is an early symptom of neurodegenerative diseases such as Parkinson disease (PD) and Alzheimer disease. However, the genetic determinants for the sense of smell have been poorly investigated.

The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review

• J Asthma Allergy
• v.8; 2015
• PMC4639549

J Asthma Allergy. 2015; 8: 125–134

• Abstract
• Fulltext

Megan F Patterson,¹ Larry Borish,^2,3 Joshua L Kennedy^1,4
1Department of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA; ²Department of Medicine, Carter Immunology Center, University of Virginia Health Systems, Charlottesville, VA, USA; ³Department of Microbiology, Carter Immunology Center, University of Virginia Health Systems, Charlottesville, VA, USA; ⁴Department of Internal Medicine, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Abstract: Asthma is a heterogeneous syndrome that might be better described as a constellation of phenotypes or endotypes, each with distinct cellular and molecular mechanisms, rather than as a singular disease. One of these phenotypes is eosinophilic asthma. As the development of eosinophilic inflammation is categorically dependent on the biological activity of Interleukin (IL)-5, IL-5 antagonism became an obvious target for therapy in this phenotype. Early trials of monoclonal antibodies targeting the biological activity of IL-5, including reslizumab, mepolizumab, and benralizumab, were performed on asthmatics with no concern for evidence of eosinophilia.

Flare-up reactions in severe drug hypersensitivity: infection or ongoing T-cell hyperresponsiveness

Clinical Case Reports Volume 3, Issue 10, pages 798–801, October 2015

1. Lukas Jörg-Walther, 
2. Benno Schnyder,
3. Arthur Helbling, 
4. Karin Helsing, 
5. Alexandra Schüller, 
6. Annette Wochner and
7. Werner Pichler
8. 1. “Flare-up” reactions are late manifestations of severe T-cell-mediated drug hypersensitivity reactions. Management is anti-inflammatory treatment and avoiding unnecessary medicines.

Hypoallergenic molecules for subcutaneous immunotherapy

Expert Review of Clinical Immunology Volume 12, Issue 1, 2016

Editorials

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Free access

DOI:

10.1586/1744666X.2016.1103182

Laurian Jongejan^a, Ronald van Ree^ab & Lars K Poulsen^b*

pages 5-7

Publishing models and article dates explained

• Published online: 11 Nov 2015

Abstract

Although a large part of the population suffers from allergies, a cure is not yet available. Allergen-specific immunotherapy (AIT) offers promise for these patients. AIT has proven successful in insect and venom allergies; however, for food allergy this is still unclear.

Treatment of Angiotensin Converting Enzyme (ACE) Inhibitor-Induced Angioedema: Guidelines

Question

What are the evidence-based guidelines regarding the treatment of patients with angiotensin-converting enzyme inhibitor-induced angioedema?

Key Message

Four evidence-based guidelines were identified regarding the treatment of patients with angiotensin-converting enzyme inhibitor-induced angioedema.

Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study

Research

P. E. Silkoff^1*, I. Strambu², M. Laviolette³, D. Singh⁴, J. M. FitzGerald⁵⁶, S. Lam⁵⁶, S. Kelsen⁷, A. Eich⁸, A. Ludwig-Sengpiel⁹, G. C hupp¹⁰, V. Backer¹¹, C. Porsbjerg¹¹, P. O. Girodet¹², P. Berger¹², R. Leigh¹³, J. N. Kline¹⁴, M. Dransfield¹⁵, W. Calhoun¹⁶, A. Hussaini¹⁷, S. Khatri¹⁸, P. Chanez¹⁹, V. S. Susulic¹, E. S. Barnathan¹, M. Curran¹, A. M. Das¹, C. Brodmerkel¹, F. Baribaud¹ and M. J. Loza¹*

Respiratory Research 2015, 16:142  doi:10.1186/s12931-015-0299-y

Abstract

Background

Asthma is a heterogeneous disease and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. The purpose of the ADEPT study was to correlate clinical features and biomarkers with molecular characteristics, by profiling asthma (NCT01274507). This report presents for the first time the study design, and characteristics of the recruited subjects.

Effect of Amino Acid Polymorphisms of House Dust Mite Der p 2 Variants on Allergic Sensitization

Allergy Asthma Immunol Res. 2016 Jan;8(1):55-62. English.

Sasipa Tanyaratsrisakul,1 Orathai Jirapongsananuruk,2 Bhakkawarat Kulwanich,1 Belinda J. Hales,3 Wayne R. Thomas,3 and Surapon Piboonpocanun1

1Institute of Molecular Biosciences, Mahidol University, Salaya, Nakorn Pathom Thailand, Thailand.

2Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand.

3Telethon Kids Institute, University of Western Australia, Perth, Australia.

Abstract

Purpose The sequence variations of the Der p 2 allergen of Dermatophagoides pteronyssinus diverge along 2 pathways with particular amino acid substitutions at positions 40,47,111, and 114. The environmental prevalence and IgE binding to Der p 2 variants differ among regions. To compare IgE binding to Der p 2 variants between sera from Bangkok, Thailand and Perth, Western Australia with different variants and to determine the variant-specificity of antibodies induced by vaccination with recombinant variants.

360 degree perspective on allergic rhinitis management in Italy: a survey of GPs, pharmacists and patients

Clin Mol Allergy. 2015; 13: 25.

Published online 2015 Nov 2. doi:  10.1186/s12948-015-0029-5

PMCID: PMC4629286

G. Walter Canonica, Massimo Triggiani, and GianEnrico Senna

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

General practitioners (GPs), community pharmacists and allergic rhinitis (AR) patients in Italy were surveyed in order to gain insight from all three perspectives into the diagnosis, management and burden of AR in Italy.