Markers of tolerance development to food allergens

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

1. Marta Ponce¹, 
2. Susanne C. Diesner¹, 
3. Zsolt Szépfalusi¹ and
4. Thomas Eiwegger^1,2,*

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Abstract

IgE-mediated reactions to food allergens are the most common cause of anaphylaxis in childhood. Although allergies to cows milk, egg or soy proteins, in contrast to peanut and tree nut allergens, resolve within the first 6 years of life in up to 60% due to natural tolerance development, this process is not well understood.

How does the efficacy and safety of Oralair® compare to other products on the market?

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Video abstract presented by Désirée Larenas-Linnemann. Abstract: Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis

Therapeutics and Clinical Risk Management » Volume 12

Désirée Larenas-Linnemann

Pediatric Allergy and Asthma Clinic, Department of Investigation, Hospital Médica Sur, México City, México

Abstract: Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis, and comparisons between AIT products with existing data, is not possible nor valid. The efficacy of two grass pollen AIT tablets, Oralair^® and Grazax^®/Grastek^®, should not be compared by looking at the percentage of score improvement in their respective trials.

Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Wandalsen GF, Mendes AI, Matsumoto F, Solé D

Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

J Investig Allergol Clin Immunol 2016; Vol 26(3): 156-160doi: 10.18176/jiaci.0036

Abstract

Objectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents.

Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5). 

Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis

Authors: E. Cantone; M. Iengo

Source: American Journal of Rhinology & Allergy  2016 June 2

Publisher: OceanSide Publications, Inc

Abstract:

Background: Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis.

Cross sectional questionnaire-based internet study: Self-perception and clinical course of drug allergy in Greece

Article in Press

Michael P. Makris

,

 Theodoros N. Sergentanis

,

 Xenophon Aggelides

,

 Stamatios Tzanninis

,

 Efthimia Polyzou

,

 Dimitrios Rigopoulos

,

 Theodora Psaltopoulou

Open Access

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Abstract

Background

Data on self perception of drug allergy in the general population are lacking. Epidemiological studies focus either on specific populations or document adverse drug reactions in general. Our objective was to document self-reported drug allergy in Greece, through a simple, informative internet-based questionnaire.

IgE in the diagnosis and treatment of allergic disease

Thomas A.E. Platts-Mills, MD, PhD

,

 Alexander J. Schuyler, BS, BA

,

 Elizabeth A. Erwin, MD

,

 Scott P. Commins, MD, PhD

,

 Judith A. Woodfolk, MBChB, PhD

DOI: http://dx.doi.org/10.1016/j.jaci.2016.04.010Article Info

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Article Outline

1. Chronic asthma in patients with sensitization to 1 or more perennial allergens
2. Diagnostic relevance of IgE antibodies to asthma
3. Understanding the role of allergens in asthmatic patients and the relevance of IgE antibodies
4. Sensitization to fungi colonizing the skin, nails, or lungs as a risk factor for allergic disease
5. Role of IgE assays in the diagnosis of different forms of food allergy: peanut anaphylaxis, eosinophilic esophagitis (EoE), and delayed anaphylaxis to red meat (the alpha-gal syndrome)
6. Relevance of the route of sensitization to the specificity and titer of IgE antibody responses
7. Conclusions
8. References

Traditionally, the concept of allergy implied an abnormal response to an otherwise benign agent (eg, pollen or food), with an easily identifiable relationship between exposure and disease. However, there are syndromes in which the relationship between exposure to the relevant allergen and the “allergic” disease is not clear.

Weekly injection of histaglobulin produces long-term remission in chronic urticaria: A prospective clinical study

Indian J Pharmacol. 2016 May-Jun; 48(3): 292–297.

doi:  10.4103/0253-7613.182884

PMCID: PMC4900003

Gurumoorthy Rajesh, Subramaniam Keerthi, Kaliaperumal Karthikeyan, and Murugan Venkatesan1

Author information ► Article notes ► Copyright and License information ►

Abstract

Objective:

Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU.

Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal

J Investig Allergol Clin Immunol 2016; Vol 26(3): 177-184 doi: 10.18176/jiaci.0039

Sánchez J, Zakzuk J, Cardona R

Abstract

Background: Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not.

Objective: To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy of treatment.