Current Trends in Prevalence and Mortality of Anaphylaxis

Current Treatment Options in Allergy pp 1–7

• Ignacio J Ansotegui, 
• Mario Sánchez-Borges, 
• Victoria Cardona 

Opinion Statement

It has not been until the last decade that we have gained insight to the global epidemiology of anaphylaxis, due to the methodological difficulties of such studies. Heterogeneity in definitions, severity grading and study designs have hampered compiling robust data which can be consistently analysed and compared. Also, previous International Classification of Diseases coding for anaphylaxis has been suboptimal further hindering epidemiological studies.

Drug-Induced Anaphylaxis: Clinical Scope, Management, and Prevention

Ensina, L et al. Curr Treat Options Allergy (2016). doi:10.1007/s40521-016-0085-1

• Luis Felipe Ensina, 
• Mara Morelo Rocha Félix, 
• Carolina Sanchez Aranda

1. 
   

Opinion statement

Drug-induced anaphylaxis (DIA) is a severe, life-threatening reaction occurring after drug exposure. It is an important cause of anaphylaxis and accounts for up to one third of drug hypersensitivity reactions. As in other anaphylaxis reactions, immunoglobulin E (IgE) has an important role in its mechanism, but other non-immunological reactions may also occur in DIA. Cutaneous and respiratory symptoms are present in a majority of patients, and cardiovascular events are more common in elderly patients.

Capsaicin Cough Responses in Asthma: Evidence for Airway Neuronal Dysfunction

Article in Press

Imran Satia, M.D.

, 

Nikolaos Tsamandouras, PhD

, 

Kimberley Holt, MPhil

, 

Huda Badri, M.D

, 

Mark Woodhead, M.D

, 

Kayode Ogungbenro, PhD

, 

Timothy W. Felton, PhD

, 

Paul M. O’Byrne, M.D

, 

Stephen J. Fowler, M.D

,

Jaclyn A. Smith, PhD

Open Access

DOI: http://dx.doi.org/10.1016/j.jaci.2016.04.045

Article Info

Abstract 

Background

Cough in asthma is a common and troublesome symptom. It is generally assumed coughing occurs as a consequence of bronchial hyper-responsiveness and inflammation, but the possibility that airway nerves are dysfunctional has not been fully explored.

Objectives

To investigate capsaicin evoked cough responses in a group of well-characterised mild to moderate asthma patients compared with healthy volunteers, and assess the influences of gender, atopy, lung physiology, inflammation and asthma control on these responses.

Estimating Influenza Outbreaks Using Both Search Engine Query Data and Social Media Data in South Korea

Journal of Medical Internet Research

Published on 04.07.16 in Vol 18, No 7 (2016): July

ABSTRACT

Background: As suggested as early as in 2006, logs of queries submitted to search engines seeking information could be a source for detection of emerging influenza epidemics if changes in the volume of search queries are monitored (infodemiology). However, selecting queries that are most likely to be associated with influenza epidemics is a particular challenge when it comes to generating better predictions.

Objective: In this study, we describe a methodological extension for detecting influenza outbreaks using search query data; we provide a new approach for query selection through the exploration of contextual information gleaned from social media data. Additionally, we evaluate whether it is possible to use these queries for monitoring and predicting influenza epidemics in South Korea.

Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation

• Scientific Reports 6, Article number: 28616 (2016)
• doi:10.1038/srep28616

Article | OPEN

Saskia Trump

, Matthias Bieg

, Zuguang Gu

, Loreen Thürmann

, Tobias Bauer

, Mario Bauer

, Naveed Ishaque

, Stefan Röder

, Lei Gu

, Gunda Herberth

, Christian Lawerenz

, Michael Borte

, Matthias Schlesner

, Christoph Plass

, Nicolle Diessl

, Markus Eszlinger

, Oliver Mücke

, Horst-Dietrich Elvers

, Dirk K. Wissenbach

, Martin von Bergen

, Carl Herrmann

, Dieter Weichenhan

, Rosalind J. Wright

, Irina Lehmann

 & Roland Eils

Abstract: Psychological stress during pregnancy increases the risk of childhood wheeze and asthma. However, the transmitting mechanisms remain largely unknown. Since epigenetic alterations have emerged as a link between perturbations in the prenatal environment and an increased disease risk we used whole genome bisulfite sequencing (WGBS) to analyze changes in DNA methylation in mothers and their children related to prenatal psychosocial stress and assessed its role in the development of wheeze in the child. We evaluated genomic regions altered in their methylation level due to maternal stress based of WGBS data of 10 mother-child-pairs.

UK prescribing practices as proxy markers of unmet need in allergic rhinitis: a retrospective observational study

Article | OPEN

npj Primary Care Respiratory Medicine 26, Article number: 16033 (2016) doi:10.1038/npjpcrm.2016.33

David B Price

, Glenis Scadding

, Claus Bachert

, Hesham Saleh

, Shuaib Nasser

, Victoria Carter

, Julie von Ziegenweidt

, Alice M S Durieux

 & Dermot Ryan

Abstract

Little data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database.

Hypersensitivities to Sesame and other common edible seeds

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) DOI: 10.1111/all.12962

Adesh Patel andSami L. Bahna*

Abstract

Several seeds have been increasingly incorporated in various food items, with consequent risk of hypersensitivity reactions that are often severe. Identification of the specific seed as the culprit is often not explored or is difficult to verify. In this article, we reviewed the English literature from January 1930 to March 2016 using PubMed and Google Scholar searching for publications relevant to hypersensitivity to common edible seeds, namely sesame, sunflower seed, poppy seed, pumpkin seed, flaxseed, and mustard seed.

Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies

Immunotherapy Posted online on June 10, 2016. (doi:10.2217/imt-2016-0023) Drug Evaluation    LT Zane*,1, S Chanda1, K Jarnagin1, DB Nelson1, L Spelman2 & LF Stein Gold3 Atopic dermatitis (AD), a chronic, relapsing, inflammatory skin disease that is characterized by intense pruritus and eczematous lesions with up to 90% of patients presenting with mild to moderate disease. Current topical treatments for AD have not changed in over 15 years and are associated with safety concerns. In AD, overactivity of phosphodiesterase 4 (PDE4), leads to inflammation and disease exacerbation.