Abediterol, a novel long-acting β2-agonist: bronchodilation, safety, tolerability and pharmacokinetic results from a single-dose, dose-ranging, active-comparator study in patients with COPD

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Jutta BeierEmail author,
• Helena Pujol,
• Beatriz Seoane,
• Eulalia Jimenez,
• Carol Astbury,
• Eric Massana,
• Sandrine Ruiz and
• Gonzalo de Miquel

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201616:102

DOI: 10.1186/s12890-016-0266-5

Open Peer Review reports

Abstract

Background

Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa, randomised, double-blind, crossover study investigated the bronchodilation, safety, tolerability and pharmacokinetics of abediterol in patients with moderate to severe COPD.

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Dr. Gary Salzman discusses the uses of pulmonary function tests for diagnosing respiratory disorders

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Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria

Allergy, Asthma & Immunology Research 2016, 8 (5): 457-60

Youin Bae, Kenji Izuhara, Soichiro Ohta, Junya Ono, Gwan Ui Hong, Jai Youl Ro, Gyeong Hun Park, Jeong Hee Choi

Abstract

Chronic spontaneous urticaria (CSU) is a complex idiopathic disease of the skin with various cellular infiltrations. Although mast cells are key effector cells in the pathogenesis of CSU, CD4+ T helper 2 cells also have particular roles in the development and maintenance of CSU. Periostin is known as a downstream molecule of interleukin (IL)-4 and IL-13, key cytokines of type 2 immune responses.

Soluble CD93 as a Novel Biomarker in Asthma Exacerbation

Allergy, Asthma & Immunology Research 2016, 8 (5): 461-5

Naseh Sigari, Ali Jalili, Laili Mahdawi, Ebrahim Ghaderi, Mohammadi Shilan

Abstract

Asthma research is shifting from studying symptoms and lung functions to the narrow-focus cellular profiles protein analysis, biomarkers, and genetic markers. The transmembrane glycoprotein CD93 is involved in endothelial cell migration, angiogenesis, leukocytes extravasation, apoptosis, innate immunity and inflammation. Relationships between the serum level of soluble CD93 (sCD93) and acute myocardial infarction/premature MI/inflammatory arthritis/skin sclerosis have recently been reported.

Immunotherapy in allergic rhinitis and lower airway outcomes

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

1. Victoria Cardona, 
2. Olga Luengo
3.  and
4. Moises Labrador
5. 1. 1. Abstract

         Allergic rhinitis and asthma constitute two clinical expressions of a single condition, respiratory allergy. Allergen immunotherapy (AIT) is a form of treatment specifically aimed at modifying the response to sensitizing allergens. The inherent potential benefit of AIT is the simultaneous treatment of all clinical expressions of respiratory allergy. Current data support the effectiveness of subcutaneous and sublingual immunotherapy in rhinitis. Studies also provide proof for a beneficial effect in allergic asthma. Even more, substantial evidence points to the preventive effect on the progression from rhinitis to asthma.
         

The impact of asthma, chronic bronchitis and allergic rhinitis on all-cause hospitalizations and limitations in daily activities: a population-based observational study

• Simone AccordiniEmail author,
• Angelo Guido Corsico,
• Lucia Calciano,
• Roberto Bono,
• Isa Cerveri,
• Alessandro Fois,
• Pietro Pirina,
• Roberta Tassinari,
• Giuseppe Verlato and
• Roberto de Marco

BMC Pulmonary Medicine201515:10

DOI: 10.1186/s12890-015-0008-0

Open Peer Review reports

Abstract

Background

Chronic respiratory diseases are a significant cause of morbidity and mortality worldwide. We sought to evaluate the impact of asthma, chronic bronchitis and allergic rhinitis on all-cause hospitalizations and limitations in daily activities in adults.

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