REVIEW
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August 1, 2016
July 31, 2016
Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence
Allergy immunotherapy (AIT) is acknowledged to produce beneficial mid- and long-term clinical and immunologic effects and increased quality of life in patients with allergic respiratory diseases (such as allergic rhinoconjunctivitis and allergic asthma). However, poor adherence to AIT (due to intentional and/or non-intentional factors) is still a barrier to achieving these benefits. There is an urgent need for patient support programs (PSPs) that encompass communication, educational and motivational components.
Burden of asthma with elevated blood eosinophil levels
RESEARCH ARTICLE
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Abstract
Background
Asthma is a common chronic condition with an economic burden of almost $56 billion annually in the US. Biologic markers like blood eosinophils, that help predict the risk of exacerbation could help guide more optimal treatment plans and reduce cost. The purpose of this study was to determine whether healthcare resource use and expenditures vary by eosinophil level among patients with asthma.
Abediterol, a novel long-acting β2-agonist: bronchodilation, safety, tolerability and pharmacokinetic results from a single-dose, dose-ranging, active-comparator study in patients with COPD
RESEARCH ARTICLE
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Abstract
Background
Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa, randomised, double-blind, crossover study investigated the bronchodilation, safety, tolerability and pharmacokinetics of abediterol in patients with moderate to severe COPD.
July 28, 2016
Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria
Allergy, Asthma & Immunology Research 2016, 8 (5): 457-60
Youin Bae, Kenji Izuhara, Soichiro Ohta, Junya Ono, Gwan Ui Hong, Jai Youl Ro, Gyeong Hun Park, Jeong Hee Choi
Abstract
Chronic spontaneous urticaria (CSU) is a complex idiopathic disease of the skin with various cellular infiltrations. Although mast cells are key effector cells in the pathogenesis of CSU, CD4+ T helper 2 cells also have particular roles in the development and maintenance of CSU. Periostin is known as a downstream molecule of interleukin (IL)-4 and IL-13, key cytokines of type 2 immune responses.
Soluble CD93 as a Novel Biomarker in Asthma Exacerbation
Naseh Sigari, Ali Jalili, Laili Mahdawi, Ebrahim Ghaderi, Mohammadi Shilan
Abstract
Asthma research is shifting from studying symptoms and lung functions to the narrow-focus cellular profiles protein analysis, biomarkers, and genetic markers. The transmembrane glycoprotein CD93 is involved in endothelial cell migration, angiogenesis, leukocytes extravasation, apoptosis, innate immunity and inflammation. Relationships between the serum level of soluble CD93 (sCD93) and acute myocardial infarction/premature MI/inflammatory arthritis/skin sclerosis have recently been reported.
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