Immunotherapy in allergic rhinitis and lower airway outcomes

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• M. Labrador-Horrillo
• Abstract
  Allergic rhinitis and asthma constitute two clinical expressions of a single-condition, respiratory allergy. Allergen immunotherapy (AIT) is a form of treatment specifically aimed at modifying the response to sensitizing allergens. The inherent potential benefit of AIT is the simultaneous treatment of all clinical expressions of respiratory allergy. Current data support the effectiveness of subcutaneous and sublingual immunotherapy in rhinitis. Studies also provide proof for a beneficial effect in allergic asthma.

Recent advances in component resolved diagnosis in food allergy

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Magnus P. Borres, , 

Nobuyuki Maruyama

, 

Sakura Sato

, 

Motohiro Ebisawa

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Open Access

DOI: http://dx.doi.org/10.1016/j.alit.2016.07.002            

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Abstract

Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions. The information may also aid the clinician in prescription of oral immunotherapy (OIT) in patients with severe symptoms, and in giving advice on food allergen avoidance or on the need to perform food challenges. The use of allergen components is rapidly evolving and increases our possibility to treat food allergic patients with a more individual approach. Using molecular allergology, we can already now better diagnose, prognose and grade the food allergy. In summary, daily routine molecular allergy diagnostics offers a number of benefits that give us a higher diagnostic precision and allow for better management of the patient.

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Is Oral Provocation Test Safe for Preschool Children?

Asian Pacific Journal of Allergy and Immunology 2016 August 16

AHEAD OF PRINT

Sait Karaman, Semiha Erdem Bahçeci, Hikmet Tekin Nacaroğlu, Canan Şule Karaman, Demet Can

Abstract

Background: Oral food challenges (OFCs) are performed for diagnosis of a food allergy where the food allergy is not supported by the history or because a newly developed tolerance needs to be established.

Objective: Our aims were to investigate the prevalence and severity of reactions during OFC in preschool children.

Evaluation of the left and right ventricular systolic and diastolic function in asthmatic children

BMC Cardiovascular DisordersBMC series – open, inclusive and trusted201616:145

DOI: 10.1186/s12872-016-0328-x

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

Esra Akyüz Özkan 

and

Hashem E. Khosroshahi

Open Peer Review reports

Abstract

Background

Asthma is the most common cause of respiratory disorders among children. We aimed to investigate left (LV) and right (RV) ventricular function in asthmatic children as detected by conventional and tissue Doppler echocardiography.

Methods

Fifty pediatric patients with asthma and forty healthy children were studied. Pulmonary function tests, electrocardiography and echocardiographic examinations were performed on all children.

Exogenous lipid pneumonia related to long-term use of Vicks VapoRub® by an adult patient: a case report

CASE REPORT

 

OPEN ACCESS

 

OPEN PEER REVIEW

• I. Cherrez OjedaEmail author,
• J. C. Calderon,
• J. Guevara,
• D. Cabrera,
• E. Calero and
• A. Cherrez

BMC Ear, Nose and Throat DisordersBMC series – open, inclusive and trusted201616:11

DOI: 10.1186/s12901-016-0032-6

Open Peer Review reports

Abstract

Background

Use of petroleum-based over the counter remedies such as Vicks VapoRub to alleviate symptoms of rhinitis is common and can be effective, but carries under-appreciated risks of adverse side effects. In this case report we highlight Exogenous Lipoid Pneumonia (ELP), an uncommon condition that results from accumulation of exogenous lipids in the alveoli, as an adverse side effect of long-term Vicks VapoRub use.

Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy

Allergy, Asthma & Clinical Immunology201612:40 

DOI: 10.1186/s13223-016-0146-9

• A. Roger,
• E. Arcalá Campillo,
• M. C. Torres,
• C. Millan,
• I. Jáuregui,
• E. Mohedano,
• S. Liñan,
• P. Verdu,
• N. Rubira,
• M. Santaolalla,
• P. González,
• A. Orovitg and
• E. VillarrubiaEmail author

Abstract

Background

Allergic rhinitis (AR) is characterised by burdensome nasal and/or ocular symptoms. This inflammatory disease can be debilitating and thus result in considerable health-related and economic consequences.

Methods

In a cross-sectional study, adult subjects with AR (N = 683) completed three allergy-specific questionnaires that assessed the impact of AR on the work/academic performance, daily activities, health-related quality of life (HRQOL), and satisfaction with allergen immunotherapy (AIT).

Specific immunotherapy ameliorates ulcerative colitis

• Email author

Allergy, Asthma & Clinical Immunology201612:37DOI: 10.1186/s13223-016-0142-0

Min Cai,

Lu Zeng,

Lin-Jing Li,

Li-Hua Mo,

Rui-Di Xie,

Bai-Sui Feng,

Peng-Yuan Zheng,

Zhi-Gang Liu,

Zhan-Ju Liu

and

Ping-Chang Yang

Background

Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients.

Methods

Patients with both ulcerative colitis (UC) and food allergy were recruited into this study. Food allergy was diagnosed by skin prick test and serum specific IgE. The patients were treated with specific immunotherapy (SIT) and Clostridium butyricum (CB) capsules.

The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe

Int J Environ Res Public Health. 2016 Jan; 13(1): 93.

Published online 2015 Dec 30. doi:  10.3390/ijerph13010093

PMCID: PMC4730484

Signe Timm,1,* Morten Frydenberg,1 Christer Janson,2 Brittany Campbell,3 Bertil Forsberg,4 Thorarinn Gislason,5,6Mathias Holm,7 Rain Jogi,8 Ernst Omenaas,9 Torben Sigsgaard,1 Cecilie Svanes,9 and Vivi Schlünssen1,10

Abstract

The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate an urban-rural gradient, assessed by place of upbringing, for asthma.