Dr. Maya Nanda describes how to do oral food challenges to evaluate food-allergic patients
A blog that publishes updates and open access scientific papers about allergy, asthma and immunology. Editor: Juan Carlos Ivancevich, MD. Specialist in Allergy & Immunology
September 17, 2016
September 5, 2016
Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin
Int. J. Mol. Sci. 2016, 17(4), 462; doi:10.3390/ijms17040462
Review
Yung-Sen Chang 1,2,3
and Bor-Luen Chiang 2,4,*
1 Department of Pediatrics, Taipei City Hospital Renai Branch, Taipei 106, Taiwan2 Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan3 School of Medicine, National Yang-Ming University, Taipei 112, Taiwan4 Department of Medical Research, National Taiwan University Hospital, Taipei 100, Taiwan
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Abstract
Sleep disturbance is common in children with atopic dermatitis (AD). It is a major factor leading to impaired quality of life in these patients and could have negative effects on neurocognitive function and behavior. However, the pathophysiology of sleep disturbance in children with AD is poorly understood, and there is no consensus on how to manage sleep problems in these patients. Pruritus and scratching could lead to sleep disruption but is unlikely the sole etiology. The circadian rhythm of cytokines, the immune system, and skin physiology such as transcutaneous water loss and skin blood flow might also play a role. Recent studies have suggested that melatonin could also be involved due to its multiple effects on sleep, immunomodulation, and anti-oxidant ability. Environmental factors should also be considered. In this review, we summarize the current understanding of the pathophysiology of sleep disturbance in children with AD, and discuss possible therapeutic implications.September 4, 2016
Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults
Abstract
Background
We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status.
Methods
One thousand one hundred ninety three Chilean adults subjects aged 22–28 living in a semi-rural area of central Chile answered a lifestyle and the European Community Respiratory Health Survey (ECRHS) questionnaires. Bronchial hyper-responsiveness (BHR) and skin prick test (SPT) to eight allergens were measured at baseline in 2001.
Cell-derived microparticles and the lung
Dario Nieri, Tommaso Neri, Silvia Petrini, Barbara Vagaggini, Pierluigi Paggiaro, Alessandro Celi
Abstract
Cell-derived microparticles are small (0.1–1 μm) vesicles shed by most eukaryotic cells upon activation or during apoptosis. Microparticles carry on their surface, and enclose within their cytoplasm, molecules derived from the parental cell, including proteins, DNA, RNA, microRNA and phospholipids. Microparticles are now considered functional units that represent a disseminated storage pool of bioactive effectors and participate both in the maintenance of homeostasis and in the pathogenesis of diseases.
September 2, 2016
Omalizumab's Impact on Total and Allergen-Specific IgE Levels: A Polyclonal Story
Free Access
Int Arch Allergy Immunol 2016;169:69-70
(DOI:10.1159/000444998)
(DOI:10.1159/000444998)
Eckl-Dorna J. |
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